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Overt Naming Fmri Pre- And Post- Tms: Two Nonfluent Aphasia Patients, With And Without Improved Naming Post- Tms, Paula I. Martin, Margaret A. Naeser, Michael Ho, Karl W. Doron, Jacquie Kurland, Jerome Kaplan, Yunyan Wang, Marjorie Nicholas, Errol H. Baker, Miguel Alonso, Felipe Fregni, Alvaro Pascual-Leone
Overt Naming Fmri Pre- And Post- Tms: Two Nonfluent Aphasia Patients, With And Without Improved Naming Post- Tms, Paula I. Martin, Margaret A. Naeser, Michael Ho, Karl W. Doron, Jacquie Kurland, Jerome Kaplan, Yunyan Wang, Marjorie Nicholas, Errol H. Baker, Miguel Alonso, Felipe Fregni, Alvaro Pascual-Leone
Jacquie Kurland
Two chronic, nonfluent aphasia patients participated in overt naming fMRI scans, pre- and post-a series of repetitive transcranial magnetic stimulation (rTMS) treatments as part of a TMS study to improve naming. Each patient received 10, 1-Hz rTMS treatments to suppress a part of R pars triangularis. P1 was a 'good responder' with improved naming and phrase length; P2 was a 'poor responder' without improved naming. Pre-TMS (10 years poststroke), P1 had significant activation in R and L sensorimotor cortex, R IFG, and in both L and R SMA during overt naming fMRI (28% pictures named). At 3 mo. post-TMS (42% …
Neural Mechanisms Underlying Learning Following Semantic Mediation Treatment In A Case Of Phonologic Alexia, Jacquie Kurland, Carlos R. Cortes, Marko Wilke, Anne J. Sperling, Susan N. Lott, Malle A. Tagamets, John Vanmeter, Rhonda B. Friedman
Neural Mechanisms Underlying Learning Following Semantic Mediation Treatment In A Case Of Phonologic Alexia, Jacquie Kurland, Carlos R. Cortes, Marko Wilke, Anne J. Sperling, Susan N. Lott, Malle A. Tagamets, John Vanmeter, Rhonda B. Friedman
Jacquie Kurland
Patients with phonologic alexia can be trained to read semantically impoverished words (e.g., functors) by pairing them with phonologically-related semantically rich words (e.g, nouns). What mechanisms underlie success in this cognitive re-training approach? Does the mechanism change if the skill is “overlearned”, i.e., practiced beyond criterion? We utilized fMRI pre- and post-treatment, and after overlearning, to assess treatment-related functional reorganization in a patient with phonologic alexia, two years post left temporoparietal stroke. Pre-treatment, there were no statistically significant differences in activation profiles across the sets of words. Post-treatment, accuracy on the two trained sets improved. Compared with untrained words, reading …
Improved Naming After Tms Treatments In A Chronic Global Aphasia Patient--Case Report, Margaret A. Naeser, Paula Martin, Marjorie Nicholas, Errol H. Baker, Heidi Seekins, Nancy Helm-Estabrooks, Carol Cayer-Meade, Masahito Kobayashi, Hugo Theoret, Felipe Fregni, Jose Maria Tormos, Jacquie Kurland, Karl W. Doron, Alvaro Pascual-Leone
Improved Naming After Tms Treatments In A Chronic Global Aphasia Patient--Case Report, Margaret A. Naeser, Paula Martin, Marjorie Nicholas, Errol H. Baker, Heidi Seekins, Nancy Helm-Estabrooks, Carol Cayer-Meade, Masahito Kobayashi, Hugo Theoret, Felipe Fregni, Jose Maria Tormos, Jacquie Kurland, Karl W. Doron, Alvaro Pascual-Leone
Jacquie Kurland
We report improved ability to name pictures at 2 and 8 months after repetitive transcranial magnetic stimulation (rTMS) treatments to the pars triangularis portion of right Broca's homologue in a 57 year-old woman with severe nonfluent/global aphasia (6.5 years post left basal ganglia bleed, subcortical lesion). TMS was applied at 1 Hz, 20 minutes a day, 10 days, over a two-week period. She received no speech therapy during the study. One year after her TMS treatments, she entered speech therapy with continued improvement. TMS may have modulated activity in the remaining left and right hemisphere neural network for naming.
Transcranial Magnetic Stimulation As A Complementary Treatment For Aphasia, Jacquie Kurland
Transcranial Magnetic Stimulation As A Complementary Treatment For Aphasia, Jacquie Kurland
Jacquie Kurland
Functional brain imaging with nonfluent aphasia patients has shown increased cortical activation (perhaps "overactivation") in right (R) hemisphere language homologues. These areas of overactivation may represent a maladaptive strategy that interferes with, rather than promotes, aphasia recovery. Repetitive transcranial magnetic stimulation (rTMS) is a painless, noninvasive procedure that utilizes magnetic fields to create electric currents in discrete brain areas affecting about a 1-cm square area of cortex. Slow frequency, 1 Hz rTMS reduces cortical excitability. When rTMS is applied to an appropriate cortical region, it may suppress the possible overactivation and thus modulate a distributed neural network for language. We …
Test-Retest Reliability Of Fmri During Nonverbal Semantic Decisions In Moderate-Severe Non-Fluent Aphasia Patients, Jacquie Kurland, Margaret A. Naeser, Errol H. Baker, Karl Doron, Paula I. Martin, Heidi E. Seeking, Andrew Bogdan, Perry Renshaw, Deborah Yurgelun-Todd
Test-Retest Reliability Of Fmri During Nonverbal Semantic Decisions In Moderate-Severe Non-Fluent Aphasia Patients, Jacquie Kurland, Margaret A. Naeser, Errol H. Baker, Karl Doron, Paula I. Martin, Heidi E. Seeking, Andrew Bogdan, Perry Renshaw, Deborah Yurgelun-Todd
Jacquie Kurland
Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no …