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Effect Of Estrogen On Chondrogenesis In Female Articular Chondrocytes, Ebony R. Parsons
Effect Of Estrogen On Chondrogenesis In Female Articular Chondrocytes, Ebony R. Parsons
Honors Undergraduate Theses
As women age and transition into menopause they face a higher risk of developing osteoarthritis leading to total joint replacements. Estrogen is the primary female reproductive hormone. As a woman approaches menopause, estrogen production decreases by 100-fold. Previous research has shown that Estrogen Replacement Therapy (ERT) reduced joint replacements in post-menopausal women. However, there is a lack of research surrounding ERT's effect on chondrocyte proliferation and extracellular matrix production, particularly 3D culture extracellular matrix production. Chondrogenesis is a process of skeletal development resulting in the formation of cartilage. Chondrocytes, derived from mesenchymal progenitors, serve as the fundamental cellular component in …
A Mixed Methods Study On Levels Of Physical Activity And Degree Of Fear Of Falling In Older Adults, Oscar L. Garcia
A Mixed Methods Study On Levels Of Physical Activity And Degree Of Fear Of Falling In Older Adults, Oscar L. Garcia
Honors Undergraduate Theses
Maintaining a physically active lifestyle has shown to decrease the risks of falling by slowing down the degenerative changes that occur with aging adults. But despite these physical changes, research has recognized the development of the fear of falling (FOF) as also attributing to the aging adults’ risk of falling. Furthermore, increases the risk of falling and subsequently increases the loss of independency. This study aimed to: 1) examine the relationships between the levels of physical activity, degree of FOF, and fall risk using quantitative approach; and 2) explore the changes of FOF and understand its cause using qualitative approach. …
The Role Of Ms-818 In Altering Age-Related Characteristics Of An In Vitro Model Of Senescence In Neural Stem Cells, Sandeep Sreerama
The Role Of Ms-818 In Altering Age-Related Characteristics Of An In Vitro Model Of Senescence In Neural Stem Cells, Sandeep Sreerama
Honors Undergraduate Theses
Aging of the brain is the leading risk factor for neurodegenerative diseases and brain cancers and has deleterious effects on brain functions. It follows that attempts to reverse the aging process may be therapeutically valuable. Neural stem cells (NSC) have been shown to play a critical role in maintaining brain functions, and their number is severely decreased with age. The development of senescence-like characteristics and declining functions in NSCs have been proposed to be responsible for brain aging and tumorigenesis. MS-818 is a pyrrolopyrimidine that has been shown to increase the NSC population and reverse the decline of behavioral function …
Investigating The Role Of Neuronal Aging In Fragile X-Associated Tremor/Ataxia Syndrome, Katlin Marie Hencak
Investigating The Role Of Neuronal Aging In Fragile X-Associated Tremor/Ataxia Syndrome, Katlin Marie Hencak
Honors Undergraduate Theses
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an X-linked late-onset neurodegenerative disorder caused by a noncoding trinucleotide repeat expansion in the FMR1 gene. This gene produces fragile x mental retardation protein (FMRP), an RNA binding protein whose targets are involved in brain development and synaptic plasticity. One of the proposed mechanisms of FXTAS pathogenesis is an RNA gain-of-function in which the repeat expansion causes toxic mRNA that sequesters important proteins in the cell, interfering with their functions. Another suggested method of pathogenesis is through a mutant protein called FMRpolyG. This protein results from repeat-associated non-AUG (RAN) translation, in which the expanded …