Digital Commons Network^™

Chytridiomycota In Tree Bark, Paige Strasko

Honors College

Chytridiomycota is a phylum of microscopic aquatic fungi that form motile spores that typically have a single posterior flagellum, thus they require water to disperse (James et al., 2000). Chytridiomycota, collectively called chytrids, have round shapes with structures called rhizoids that absorb nutrients and anchor them to their substrate (Mueller et al., 2004). Chytrids are typically found in aquatic environments and soils since zoospores require water to germinate (James et al., 2000), but they also have been found in a number of unexpected environments. Chytrids are difficult to find because they are microscopic and have time-sensitive life cycles (Mueller et …

A Mathematical Model Of The Opioid Epidemic In The State Of Maine, Cole Butler

Honors College

For the past two decades the United States has been embroiled in a prescription drug epidemic that has since grown in magnitude and complexity. The ripples of this epidemic have been especially apparent in the state of Maine, which has fought hard to mitigate the damage caused by addiction to pharmaceutical and illicit opioids. Us- ing data from state and federal sources, we construct a mathematical model capturing the dynamics of the opioid epidemic in the state of Maine, specifically as it pertains to pharmaceutical opioids and heroin. Parameter fitting is performed followed by an uncertainty analysis to quantify potential …

Clostridioides Difficile Infection Rates And Diabetes Mellitus In The Acute Care Hospital Setting: A Pilot Retrospective Study, Abigail Howe

Honors College

Clostridioides difficile infections (CDI) are bacterial infections severely affecting an individual’s health and financially affecting health care settings. These infections are a persistent health care issue despite implementation of preventative measures. Research on the risk of acquiring CDI for individuals with comorbidities is scarce. Diabetes mellitus (DM) may negatively impact an individual’s immune system and consequently increase the risk of CDI. The purpose of this pilot study was to determine if the incidence of DM differed between patients who had CDI and patients who did not have CDI. After receiving an Internal Review Board (IRB) exempt status, electronic medical records …

Honors College_Honors 112 Class "Screw This Virus"_Essay, Patrick Fleming

Honors College

Essay by University of Maine student Patrick Fleming for HON 112, featuring COVID-19.

The Impact Of Emotion Regulation On Adhd And Depressive Symptoms In Emerging Adults, Hannah Meidahl

Honors College

The present thesis describes a study examining the process of emotion regulation (ER) and its connections to symptoms of two forms of psychopathology, attentiondeficit/hyperactivity disorder (ADHD) and depression, both separately and comorbidly. ER can be characterized as the processes and components that make up a person’s ability to express, experience, and control his/her emotions. It is theorized to be an important component of a variety of psychological disorders, including ADHD and depression. ER has been found to play a vital role in the development of both of these disorders and there has been speculation that ER may explain some of …

The Use Of Smartphone Apps As A Supplement To Transgender Voice And Communication Therapy, Maura Philippone

Honors College

This university IRB-approved thesis follows a case study research design and investigates the effectiveness of the app “Voice Analyst” as a supplement to transgender voice and communication therapy. It is hypothesized that the use of “Voice Analyst” outside the clinic will enable participants to make greater progress and to increase their ability to retain their progress. The participants are four transgender women who want to raise the pitch of their speaking voices. The participants are asked to record themselves reading “The Rainbow Passage,” and their data are tracked in a spreadsheet. “The Rainbow Passage” is the standardized passage used for …

Idiom Comprehension In Adults With And Without Reading Comprehension Difficulties, Molly Brown

Honors College

Figurative language, also known as nonliteral language, is the use of words in a way that deviates from their intended or literal meaning. Idioms are a specific form of figurative language, where the words of the phrase are not reflective of the meaning of the idiom. For example, to tie the knot means to get married, which is different from the physical act of tying a knot in a string. A great deal of research has focused on idiom comprehension in children with reading difficulties, while few studies have examined this issue in adult struggling readers. Many of the skills …

Assessing Health Related Quality Of Life, Language Impairment, And Psychosocial Factors In Post-Stroke Aphasia, Sophia M.E. Palangas

Honors College

Aphasia, an impairment of language comprehension and production typically due to an acquired brain injury or stroke, has been shown to negatively impact an individual’s quality of life (Hilari, Needle, & Harrison, 2012). It has also been shown that people with aphasia (PWA) have an increased risk of developing depression (Kauhanen et al., 2000). There are few current assessments or screening tools which focus on depression in aphasia and the relationship between mood disorders and prognosis for language recovery. This type of screening tool is critical to identify a PWA’s susceptibility for depression because depression elongates and/or prevents language recovery …

The Functional Role Of Glia In Peripheral Metabolic Tissue, Emma Paradie

Honors College

With the ever-growing pandemic of obesity comes a multitude of consequential morbidities, such as increased risk of heart disease and type II Diabetes Mellitus. Secondary to diabetes is diabetic neuropathy, the regression or dying back of nerves that often occurs in the extremities, leading to loss of sensation or pain. Additionally, aging is a risk factor for obesity, diabetes, and neuropathy. Responsible for the communication between the extremities and peripheral tissues, such as adipose (fat), and the brain, is the peripheral nervous system. The peripheral nervous system is the umbrella under which varying types of nerves are designated, including sympathetic, …

Cpap-Compliance Of Aging Individuals With Obstructive Sleep Apnea With Or Without Mild Cognitive Impairment, Bailey Carter

Honors College

With approximately 20% of Americans affected by obstructive sleep apnea (OSA), and over 30% of sleep apneic patients non-compliant with the most common form of treatment, CPAP (Continuous Positive Airway Pressure), the proposed study looks to investigate the relationship between OSA, CPAP-compliance, and cognitive decline associated with many aging-related neurodegenerative diseases [1, 2]. Our group has performed in-home sleep studies using a patented, sensor mattress-sheet device, and standard actigraphy. Demographics including a questionnaire on OSA compliance and neurocognitive tests were administered to participants between 62 and 90 years of age. Cognitive decline meeting criteria for MCI (Mild Cognitive Impairment, the …

Identifying The Link Between Non-Coding Regulatory Rnas And Phenotypic Severity In A Zebrafish Model Of Gmppb Dystroglycanopathy, Grace Smith

Honors College

Muscular Dystrophy (MD) is characterized by varying severity and time-of-onset by individuals afflicted with the same forms of MD, a phenomenon that is not well understood. MD affects 250,000 individuals in the United States and is characterized by mutations in the dystroglycan complex. gmppb encodes an enzyme that glycosylates dystroglycan, making it functionally active; thus, mutations in gmppb cause dystroglycanopathic MD1 . The zebrafish (Danio rerio) is a powerful vertebrate model for musculoskeletal development and disease. Like human patients, gmppb mutant zebrafish present both mild and severe phenotypes. In order to understand the molecular mechanisms involved, we performed high-throughput RNA …

Characterization Of Ncf1 Mutants In A Zebrafish Model Of Innate Immune Function With Human Influenza A Virus Infection, Lily Charpentier

Honors College

Seasonal influenza A virus (IAV) infections and their associated respiratory diseases are the cause of an estimated 650,000 deaths each year, according to the World Health Organization. The zebrafish (Danio rerio) is a powerful vertebrate model to study innate immune function and host-pathogen interactions as the function of neutrophils and other phagocytes can be characterized in vivo. Preliminary studies have shown an increase in neutrophil respiratory burst activity to eliminate the invading pathogen, yet little is known of all of the mechanisms involved in neutrophil function. The NADPH oxidase complex, of which neutrophil cytosolic factor 1 (Ncf1) is a key …

Adolescent Depressive Symptoms, Co-Rumination, And Friendship: A Longitudinal, Observational Study, Raegan Harrington

Honors College

Depressive symptoms and positive friendship quality are typically inversely correlated across numerous past studies, with most studies involving only two time points. At the same time, co-rumination (Rose, 2002), the mutually encouraged, speculative, repetitive, and negatively focused discussion of problems between friends, has been linked to increased depressive symptoms and increased friendship quality concurrently and over time (Calmes & Roberts, 2008; Rose et al., 2007, 2014). Yet unclear is how co-rumination impacts associations of depressive symptoms and friendship quality over time and the nature of these relations over more than two time points. Additionally, understudied are observations of co-rumination, with …

Designing A Platform To Detect Peripheral Neuropathy With Microneedle Electrodes And Neurophysiology, Erin Merchant

Honors College

The growing obesity pandemic has caused diabetes to become one of the world’s leading health concerns. Diabetic individuals often suffer from peripheral neuropathy, which is nerve death that typically starts at the extremities and moves from the skin inward to deeper tissues. This nerve death causes painful symptoms including tingling, stinging, numbness, and others. Current methods to diagnose peripheral neuropathy by measuring nerve function are invasive and painful since they target large axons of the legs; however, by the time the neuropathy reaches the diagnosable axons, it is often too late for intervention. Although no cures for neuropathy are established, …

A Biogeographical Assessment Of Arctic Marine Fungi, Bentley E. Simpson

Honors College

Marine fungi play a crucial role in recycling nutrients and channeling energy to higher trophic levels in the world oceans. Despite their critical role, their distributions and community composition, particularly in the Arctic, are largely unknown. This study reveals depth-related trends of abundance, diversity, and community composition of Arctic marine fungi through analysis of data obtained in the Tara Oceans expedition. With samples from surface (0-50 m), deep chlorophyll max (50-200 m), and mesopelagic (200-1000 m) depths, relative abundance, operational taxonomic unit (OTU) richness, and diversity were found to increase as a function of depth. Basidiomycota and Ascomycota were found …

The Educational Needs Of Children Ages 0-5 Born With Neonatal Abstinence Syndrome In Maine, Julia Casey

Honors College

The goal of this study is to better understand the educational needs of children born with neonatal abstinence syndrome (NAS) in Maine. This study will consider two questions. First, what is currently being done to help children born with NAS in Maine? To answer this question, I looked into previous studies that evaluate the needs of children born with prenatal drug exposure. I also looked into Maine’s Strategic Action Opioid Plan to determine what initiatives the state is taking towards helping these children. Second, what should Maine be doing to help the children born with NAS? To answer this question, …

The Effects Of Food Insecurity On Indigenous Women In Maine, Sara Imam

Honors College

Indigenous women have been affected by food insecurity due to historical and continued impacts of settler-colonialism, which include the stripping of traditional gendered roles and responsibilities, environmental degradation, and poverty that limit access to traditional foods and resources. As a result, Indigenous women remain among the most vulnerable to malnourishment and hunger, as well as chronic health conditions that arise in part from colonial diets. Despite the severity of this issue in Native North America, there has been little research carried out on the topic in the state of Maine. This thesis analyzes the connections between factors underlying food insecurity …

In Vivo Imaging Of The Respiratory Burst Response To Influenza A Virus Infection, James Thomas Seuch

Honors College

The CDC estimated that seasonal influenza A virus (IAV) infections resulted in 490,600 hospitalizations and 34,200 deaths in the US in the 2018-2019 season. The longterm goal of our research is to understand how to improve innate immune responses to IAV. During IAV infection, neutrophils and macrophages initiate a respiratory burst response where reactive oxygen species (ROS) are generated to destroy the pathogen and recruit additional immune cells. While ROS molecules, such as hydrogen peroxide, help clear the virus, the signaling cascade can also lead to excess neutrophil recruitment, hyperinflammation, and tissue damage. Regulatory mechanisms that trigger overactivation of neutrophils …

Honors College_Honors 112 Class "Screw This Virus"_Alternate Final Exam Prompt, Sharon S. Tisher, Melissa Landenheim

Honors College

Email thread featuring messages from Melissa Ladenheim, Associate Dean, Honors College, University of Maine to the Provost Office and from Dr. Ladenheim to Sharon S. Tisher, Lecturer, School of Economics and Honors College, University of Maine regarding one optional prompt for Tisher's take home exam in the two Honors 112 classes that incorporated COVID-19.

Honors College_Honors 112 Class "Screw This Virus"_Examination & Essay Responses, Katie Quirk, Melissa Ladenheim

Honors College

Honors 112 Final Essay Exam questions and excerpts from student's responses for a class taught by Katie Quirk, Lecturer, Honors College and College of Education, University of Maine.

Also, includes email thread featuring messages from Melissa Ladenheim, Associate Dean, Honors College, University of Maine to the Provost Office and from Dr. Ladenheim to Professor Quirk regarding the course material.