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Medicine and Health Sciences

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South Dakota State University

Electronic Theses and Dissertations

Theses/Dissertations

2013

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Development Of A Subunit Vaccine Against Bovine Diarrhea Caused By K99 Enterotoxigenic Escherichia Coli And Bovine Viral Diarrhea Virus, Emad Hashish Jan 2013

Development Of A Subunit Vaccine Against Bovine Diarrhea Caused By K99 Enterotoxigenic Escherichia Coli And Bovine Viral Diarrhea Virus, Emad Hashish

Electronic Theses and Dissertations

Bovine diarrhea is economically one of the most important problems in cattle industry. Enterotoxigenic Escherichia coli (ETEC), particularly strains expressing K99 (F5) fimbriae and heat-stable type I (STa) enterotoxin is the predominant bacterial cause of diarrhea in calves; whereas bovine viral diarrhea virus (BVDV) causes diarrhea and other illness to cattle at all ages. A vaccine that prevents against both K99 fimbrial ETEC and BVDV could benefit greatly to cattle producers worldwide. We hypothesized that a novel multivalent vaccine composed of K99, STa and BVDV E2 antigens could induce immunity for broad protection against bovine diarrhea. In this study we …


Risk Factors For Release In Nurses With Substance Use Disorder, Kathleen J. Tinklenberg Jan 2013

Risk Factors For Release In Nurses With Substance Use Disorder, Kathleen J. Tinklenberg

Electronic Theses and Dissertations

Substance Use Disorder (SUD) is defined as the continued use of mood-altering addicting substances despite adverse consequences (Morse & Flavin, 1992). Nurses are not immune from this progressive and fatal disease and if left untreated, a nurse with SUD poses a double jeopardy: risk to the patients and a threat to her or his own health. Many State Boards of Nursing (SBN) have implemented a non-disciplinary alternative to punitive treatment of professionals with SUD; such programs offer monitoring for nurses afflicted with SUD. While studies have found a lower relapse rate for healthcare professionals enrolled in these monitoring programs than …