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Recent Highlights In The Development Of Isatin-Based Anticancer Agents, Kara L. Vine, Lidia Matesic, Julie M. Locke, Danielle Skropeta
Recent Highlights In The Development Of Isatin-Based Anticancer Agents, Kara L. Vine, Lidia Matesic, Julie M. Locke, Danielle Skropeta
Danielle Skropeta
Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and trisubstitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, …
Development Of A Clinician-Led Research Agenda For General Practice Nurses, Elizabeth J. Halcomb, Louise Hickman
Development Of A Clinician-Led Research Agenda For General Practice Nurses, Elizabeth J. Halcomb, Louise Hickman
Elizabeth Jane Halcomb Professor
Objective: This study sought to identify and prioritise research issues as perceived by Australian general practice nurses. In this context, a research priority refers to the most pressing research problems that necessitate exploration to improve clinical practice. Design: This paper reports the findings of a two-round Delphi study. Initially, focus groups identified research issues. Subsequently, an online survey facilitated ranking of these issues on a 5-point Likert scale. Setting: Australian general practices. Subjects: Twenty-five practice nurses participated in the focus groups and 145 practice nurses responded to an online survey. Main outcome measure(s): The main outcome measure was the prioritisation …
Strategic Leadership Capacity Development For Ict: Moving Beyond Learning On The Job, Geraldine Lefoe, Dominique Parrish
Strategic Leadership Capacity Development For Ict: Moving Beyond Learning On The Job, Geraldine Lefoe, Dominique Parrish
Geraldine Lefoe
Leadership for change is a key component for universities striving to find new ways to meet the needs of their future students. This paper discusses an innovative framework for leadership capacity development which has been implemented in a number of Australian universities. The framework, underpinned by a distributive approach to leadership, prepares a new generation of leaders for formal positions of leadership in all aspects of teaching and learning. Through the Faculty Scholars Program a number of teaching and learning innovations were implemented, including a number using innovative technologies, to establish strategic change within their faculties. The Scholars shared their …