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- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (2)
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- Administration and dosage of enzyme activators and inhibitors (1)
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Articles 1 - 9 of 9
Full-Text Articles in Entire DC Network
The Association Of Nov/Ccn3 With Obstructive Sleep Apnea (Osa): Preliminary Evidence Of A Novel Biomarker In Osa, J Weingarten, Lars Bellner, S Peterson, M Zaw, P Chadha, S Singh, Nader Abraham
The Association Of Nov/Ccn3 With Obstructive Sleep Apnea (Osa): Preliminary Evidence Of A Novel Biomarker In Osa, J Weingarten, Lars Bellner, S Peterson, M Zaw, P Chadha, S Singh, Nader Abraham
Nader G. Abraham
Obstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk. Ten morbidly obese and 10 healthy lean subjects underwent overnight polysomnography (PSG) and clinical evaluation. Blood samples were analyzed for NOV levels, adiponectin and …
Regulation Of Diabetic Cardiomyopathy By Caloric Restriction Is Mediated By Intracellular Signaling Pathways Involving 'Sirt1 And Pgc-1alpha', Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Michal Laniado-Schwartzman, Nader G. Abraham, Edith Hochhauser
Regulation Of Diabetic Cardiomyopathy By Caloric Restriction Is Mediated By Intracellular Signaling Pathways Involving 'Sirt1 And Pgc-1alpha', Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Michal Laniado-Schwartzman, Nader G. Abraham, Edith Hochhauser
Nader G. Abraham
BACKGROUND: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibrosis, both of which are aggravated by angiotensin. Caloric restriction (CR) is cardioprotective in animal models of heart disease through its catabolic activity and activation of the expression of adaptive genes. We hypothesized that in the diabetic heart; this effect involves antioxidant defenses and is mediated by SIRT1 and the transcriptional coactivator PGC-1alpha (Peroxisome proliferator-activated receptor-gamma coactivator). METHODS: Obese Leptin resistant (db/db) mice …
Pnaktide Attenuates Steatohepatitis And Atherosclerosis By Blocking Na/K-Atpase/Ros Amplification In C57bi6 And Apoe Knockout Mice Fed A Western Diet, K Sodhi, K Srikanthan, P Goguet-Rubio, A Nichols, A Mallick, A Nawab, R Martin, P Shah, M Chaudhry, S Sigdel, M El-Hamdani, J Liu, Z Xie, Nader Abraham, J Shapiro
Pnaktide Attenuates Steatohepatitis And Atherosclerosis By Blocking Na/K-Atpase/Ros Amplification In C57bi6 And Apoe Knockout Mice Fed A Western Diet, K Sodhi, K Srikanthan, P Goguet-Rubio, A Nichols, A Mallick, A Nawab, R Martin, P Shah, M Chaudhry, S Sigdel, M El-Hamdani, J Liu, Z Xie, Nader Abraham, J Shapiro
Nader G. Abraham
We have previously reported that the alpha1 subunit of sodium potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, we speculated that blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. To test this hypothesis, pNaKtide was administered to a murine model of NASH: the C57Bl6 mouse fed a "western" diet containing high amounts of fat and fructose. The administration of pNaKtide reduced obesity as well as hepatic steatosis, inflammation and fibrosis. Of interest, we also noted …
Existence Of A Strong Correlation Of Biomarkers And Mirna In Females With Metabolic Syndrome And Obesity In A Population Of West Virginia, P Goguet-Rubio, R Klug, D Sharma, K Srikanthan, N Puri, V Lakhani, A Nichols, K O'Hanlon, Nader Abraham, J Shapiro, K Sodhi
Existence Of A Strong Correlation Of Biomarkers And Mirna In Females With Metabolic Syndrome And Obesity In A Population Of West Virginia, P Goguet-Rubio, R Klug, D Sharma, K Srikanthan, N Puri, V Lakhani, A Nichols, K O'Hanlon, Nader Abraham, J Shapiro, K Sodhi
Nader G. Abraham
Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS). Results: Serum levels of leptin, adiponectin, leptin: adiponectin ratio, IL-6, six miRNAs (320a, 197-3p, 23-3p, 221-3p, 27a-3p, and 130a-3p), were measured. Among the three groups, …
Development Of Nash In Obese Mice Is Confounded By Adipose Tissue Increase In Inflammatory Nov And Oxidative Stress, David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Aliza Meissner, Ilana Grant, Nader G. Abraham
Development Of Nash In Obese Mice Is Confounded By Adipose Tissue Increase In Inflammatory Nov And Oxidative Stress, David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Aliza Meissner, Ilana Grant, Nader G. Abraham
Nader G. Abraham
Aim: Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity. We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO-1) levels in adipose and hepatic tissue, resulting in the development of NASH in obese mice. Methods: Mice were fed a high fat diet (HFD) and obese animals were administered an HO-1 inducer with or without an inhibitor of HO activity to examine levels of adipose-derived NOV and possible links between increased synthesis of inflammatory adipokines and hepatic pathology. Results: NASH mice displayed decreased HO-1 levels and HO …
Cyp-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal Of Heart Failure In Obesity-Induced Diabetic Cardiomyopathy Via Pgc-1 Alpha Activation, Shailendra Singh, John A. Mcclung, Lars Bellner, Jian Cao, Maayan Waldman, Joseph Schragenheim, Nader G. Abraham
Cyp-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal Of Heart Failure In Obesity-Induced Diabetic Cardiomyopathy Via Pgc-1 Alpha Activation, Shailendra Singh, John A. Mcclung, Lars Bellner, Jian Cao, Maayan Waldman, Joseph Schragenheim, Nader G. Abraham
Nader G. Abraham
We have previously shown that an Epoxyeicosatrienoic Acid (EET) -agonist has pleiotropic effects and reverses cardiomyopathy by decreasing inflammatory molecules and increasing antioxidant signaling. We hypothesized that administration of an EET agonist would increase Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1alpha), which controls mitochondrial function and induction of HO-1 and negatively regulates the expression of the proinflammatory adipokines CCN3/NOV in cardiac and pericardial tissues. This pathway would be expected to further improve left ventricular (LV) systolic function as well as increase insulin receptor phosphorylation. Measurement of the effect of an EET agonist on oxygen consumption, fractional shortening, blood glucose levels, thermogenic and …
Corrigendum: Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, J Liu, J Tian, M Chaudhry, K Maxwell, Y Yan, X Wang, P Shah, A Khawaja, R Martin, T Robinette, A El-Hamdani, M Dodrill, K Sodhi, C Drummond, S Haller, D Kennedy, Nader Abraham, Z Xie, J Shapiro
Corrigendum: Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, J Liu, J Tian, M Chaudhry, K Maxwell, Y Yan, X Wang, P Shah, A Khawaja, R Martin, T Robinette, A El-Hamdani, M Dodrill, K Sodhi, C Drummond, S Haller, D Kennedy, Nader Abraham, Z Xie, J Shapiro
Nader G. Abraham
This corrects the article DOI: 10.1038/srep34592.
Ablation Of Adipose-Ho-1 Expression Increases White Fat Over Beige Fat Through Inhibition Of Mitochondrial Fusion And Of Pgc1alpha In Female Mice, S Singh, I Grant, A Meissner, A Kappas, Nader Abraham
Ablation Of Adipose-Ho-1 Expression Increases White Fat Over Beige Fat Through Inhibition Of Mitochondrial Fusion And Of Pgc1alpha In Female Mice, S Singh, I Grant, A Meissner, A Kappas, Nader Abraham
Nader G. Abraham
Background Hmox1 plays an important role in the regulation of mitochondrial bioenergetics and function by regulating cellular heme-derived CO and bilirubin. Previous studies have demonstrated that global disruption of HO-1 in humans and mice resulted in severe organ dysfunction. Methods We investigated the potential role of adipose-specific-HO-1 genetic ablation on adipose tissue function, mitochondrial quality control and energy expenditure by generating an adipo-HO-1 knockout mouse model (Adipo-HO-1-/-) and, in vitro, adipocyte cells in which HO activity was inhibited. Adiposity, signaling proteins, fasting glucose and oxygen consumption were determined and compared to adipocyte cultures with depressed levels of both HO-1/HO-2. Results …
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
Nader G. Abraham
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL. Further stimulation of the NKAL with ouabain augmented cellular senescence whereas treatment with pNaKtide attenuated it. …