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Dual Mechanisms Of Regulation Of Type I Iodothyronine 5'-Deiodinase In The Rat Kidney, Liver, And Thyroid Gland. Implications For The Treatment Of Hyperthyroidism With Radiographic Contrast Agents., Donald L. St Germain
Dual Mechanisms Of Regulation Of Type I Iodothyronine 5'-Deiodinase In The Rat Kidney, Liver, And Thyroid Gland. Implications For The Treatment Of Hyperthyroidism With Radiographic Contrast Agents., Donald L. St Germain
Dartmouth Scholarship
Alterations in thyroid hormone status and the administration of radiographic contrast agents can markedly influence iodothyronine metabolism and, in particular, the activity of type I 5'-deiodinase (5'DI). In the present studies, the mechanisms responsible for these effects have been reassessed. As previously reported, the addition of iopanoic acid (IOP) to broken cell preparations resulted in a competitive pattern of 5'DI inhibition. However, the in vivo administration to rats of IOP or 3,3',5'-triiodothyronine (rT3) resulted in a noncompetitive pattern of inhibition of 5'DI in the liver, kidney, and thyroid gland, whereby marked decreases in maximal enzyme velocity (V max) were noted, …