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Efficacy Of N-Acetylcysteine On Prevention And Amelioration Of Cisplatin-Induced Ototoxicity: A Systematic Literature Review, Maryana Peravozchykava

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.

Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.

Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.

Discussion: The significant variability in findings on NAC otoprotective efficacy …

A Review Of Animal Studies For The Efficacy Of D-Methionine In Reducing Threshold Shifts And Affecting Biochemical Changes After Exposure To Noise, Alexandra Petraru

Dissertations, Theses, and Capstone Projects

Noise induced hearing loss (NIHL) is a major public health concern in the United States and worldwide. Certain individuals such as factory workers and military personnel are at greatest risk for irreversible sensorineural hearing loss due to the limitations of hearing protection measures and devices. D-Methionine (d-Met) is an antioxidant otoprotective agent that currently is in human clinical trials. The purpose of this systematic literature review was to review d-Met’s efficacy in reducing threshold shifts as well as in producing biochemical and physical changes in animal studies vis-à-vis the administration paradigm (preloading, rescue and a combined approach), d-Met dose quantity …