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- Blood transfusion;Caesarean section;hospital stay;neonatal admission;trial of labour;vaginal birth after Caesarean (1)
- Cesarean delivery; Gestational diabetes; Glucose challenge test; Labor induction; Macrosomia (1)
- Gestational diabetes;glucose challenge test;glucose tolerance test;risk factors;screening (1)
- Hypertension;labetalol;nifedipine;pre-eclampsia;pregnancy;trial (1)
- Placebo-controlled trial; clinical indicators; severity; efficacy (1)
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Oral Nifedipine Versus Intravenous Labetalol For Acute Blood Pressure Control In Hypertensive Emergencies Of Pregnancy: A Randomised Trial, Siti Zawiah Omar
Oral Nifedipine Versus Intravenous Labetalol For Acute Blood Pressure Control In Hypertensive Emergencies Of Pregnancy: A Randomised Trial, Siti Zawiah Omar
Siti Zawiah Omar
Objective To compare oral nifedipine with intravenous labetalol in their rapidity to control hypertensive emergencies of pregnancy. Design A double-blind randomised trial. Setting A university hospital in Malaysia. Population Pregnant women with severe gestational hypertension >= 160/110 mmHg who required immediate treatment. Methods Patients were randomised to receive nifedipine (10 mg tablet, orally, up to five doses) and intravenous placebo saline injection or intravenous labetalol injection (in an escalating dose regimen of 20, 40, 80, 80 and 80 mg) and a placebo tablet every 15 minutes until the target blood pressure of <= 150/100 mmHg was achieved. Crossover treatment was effected if the initial treatment regimen was unsuccessful. Main outcome measure The time taken to achieve a blood pressure of <= 150/100 mmHg. Results The median time taken to achieve target blood pressure was 30 minutes (interquartile range, IQR 22.5-67.5 minutes) versus 45 minutes (IQR 30-60 minutes) for nifedipine and labetalol, respectively (P = 0.59). Repeated measures analysis of variance indicated that in the first hour both systolic (F = 87.6, P < 0.001) and diastolic (F = 55.8, P < 0.001) blood pressure significantly decreased, but there was no difference between the nifedipine and labetalol groups for both systolic (F = 0.12, P = 0.74) and diastolic (F = 0.92, P = 0.34) blood pressure trends over time. Crossover treatment was required in 20% of women from each group. Conclusions Oral nifedipine and intravenous labetalol regimens are similarly effective in the acute control of severe hypertension in pregnancy.
Promethazine Compared With Metoclopramide For Hyperemesis Gravidarum A Randomized Controlled Trial, Siti Zawiah Omar
Promethazine Compared With Metoclopramide For Hyperemesis Gravidarum A Randomized Controlled Trial, Siti Zawiah Omar
Siti Zawiah Omar
OBJECTIVE: To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum. METHODS: Women at their first hospitalization for hyperemesis gravidarum were approached when intravenous antiemetic therapy was needed. They were randomly assigned to receive 25 mg promethazine or 10 mg metoclopramide every 8 hours for 24 hours in a double-blind study. Primary outcomes were vomiting episodes by diary and well-being visual numerical rating scale score (10-point scale) in the 24-hour main study period. Participants also filled out an adverse-effects questionnaire at 24 hours and a nausea visual numerical rating scale score at recruitment and at 8, 16, …
The 50-G Glucose Challenge Test And Pregnancy Outcome In A Multiethnic Asian Population At High Risk For Gestational Diabetes, Siti Zawiah Omar
The 50-G Glucose Challenge Test And Pregnancy Outcome In A Multiethnic Asian Population At High Risk For Gestational Diabetes, Siti Zawiah Omar
Siti Zawiah Omar
Objective: To evaluate the 50-g glucose challenge test (GCT) on pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes (GDM). Methods: GCT was positive if the 1-hour plasma glucose level was >= 7.2 mmol/L. GDM was diagonsed by a 75-g glucose tolerance test using WHO (1999) criteria. Of the 1368 women enrolled in the study, 892 were GCT negative, 308 were GCT false-positive status was associated with preterm birth (adjusted odds ration [AOR] 2.1; 95% CI, 3.3-7.5), cesarean delivery (AOR 2.5; 95% CI, 1.6-3.2), postpartum hemorrhage (AOR 2.1; 95% CI, 1.2-3.7), and neonatal macrosomia (AOR 2.5; …
A Placebo-Controlled Trial Of Oral Pyridoxine In Hyperemesis Gravidarum, Siti Zawiah Omar
A Placebo-Controlled Trial Of Oral Pyridoxine In Hyperemesis Gravidarum, Siti Zawiah Omar
Siti Zawiah Omar
Objective: To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG). Methods: Patients with HG were randomized at hospitalization to 20 mg oral pyridoxine thrice daily or to placebo. Intravenous rehydration, metoclopramide and oral thiamine were also administered. Metoclopramide and thiamine were continued for 2 weeks after discharge. Rehospitalization for HG in the 2-week study period was ascertained, vomiting was recorded by diary, and nausea was evaluated with a 10-point visual analogue scale (VAS) at enrolment, after hospital discharge and on week 1 and 2 reviews. Results: Ninety-two women were included in the analysis. …
Screening For Gestational Diabetes At Antenatal Booking In A Malaysian University Hospital: The Role Of Risk Factors And Threshold Value For The 50-G Glucose Challenge Test, Siti Zawiah Omar
Siti Zawiah Omar
Background: The best method of screening for gestational diabetes (GDM) remains unsettled. The 50-g glucose challenge test (GCT) is used in a two-stage screening process but its best threshold value can vary according to population. Aims: To evaluate the role of risk factors in conjunction with GCT and to determine an appropriate threshold for the one-hour venous plasma glucose with the GCT Method: In a prospective study, 1600 women at antenatal booking without a history of diabetes mellitus or GDM filled a form on risk factors before GCT Women who had GCT >= 7.2 mmol/L underwent the 75-g oral glucose …
Labour And Perinatal Outcome In Women At Term With One Previous Lower-Segment Caesarean: A Review Of 1000 Consecutive Cases, Siti Zawiah Omar
Labour And Perinatal Outcome In Women At Term With One Previous Lower-Segment Caesarean: A Review Of 1000 Consecutive Cases, Siti Zawiah Omar
Siti Zawiah Omar
Objective: To compare the outcome in 1000 women at term with one lower transverse Caesarean that was suitable for a trial of labour. Methods: One thousand consecutive women with one previous scar suitable for a trial of labour delivering in our centre from June 2002 to December 2005 were identified from the labour ward register. Data were retrieved from patients' charts, and neonatal admissions were determined. Results: In the study, 76.8% of women underwent a trial of labour, with a 71.2% vaginal birth rate. Hospital stay was shorter with a trial of labour. The three perinatal deaths (0.4%; P = …
Membrane Sweeping At Initiation Of Formal Labor Induction - A Randomized Controlled Trial, Siti Zawiah Omar
Membrane Sweeping At Initiation Of Formal Labor Induction - A Randomized Controlled Trial, Siti Zawiah Omar
Siti Zawiah Omar
OBJECTIVE: To determine the benefit of membrane rate, reduced oxytocic drug use, shortened induction to sweeping at initiation of labor induction in conjunction delivery interval, and improved patient satisfaction. with formal methods of labor induction. METHODS: Two hundred seventy-four women at term with a singleton fetus in cephalic presentation and intact membranes were randomly assigned to receive membrane sweeping or no membrane sweeping at initiation of formal labor induction with either dinoprostone pessary or amniotomy. Outcome measures included mode of delivery, induction-to-delivery interval, dinosprostone dose, any oxytocin use and duration of oxytocin use in labor, visual analog score for pain …