Digital Commons Network^™

Selective Increases In Antibody Isotypes And Immunoglobulin G Subclass Responses To Secreted Antigens In Tuberculosis Patients And Healthy Household Contacts Of The Patients, R Hussain, G Dawood, N Abrar, Z Toossi, A Minai, M Dojki, J J. Ellner

Department of Pathology and Laboratory Medicine

Mycobacterium tuberculosis-specific antibodies (immunoglobulin M [IgM], IgE, IgG, and IgG subclasses) were determined in 164 tuberculosis patients (pulmonary involvement, n = 135; lymph node involvement, n = 29), 59 healthy household contacts (HC), and 51 healthy endemic donors (EC) by a quantitative enzyme-linked immunosorbent assay for reactivity with culture filtrate. Among the isotypes, significant differences between tuberculosis patient groups with either pulmonary or lymph node involvement and healthy control groups (HC and EC) were detected only for IgG (P < 0.001) and IgG1 (P < 0.001) antibodies. Pulmonary patients also showed a significant difference with IgM (P < 0.01) and IgE (P < 0.05) antibodies. HC showed elevation of only IgM antibodies compared with EC, indicating that IgM antibodies may be an indicator of recent infection with M. tuberculosis. These results suggest that the switching of IgM antibody response to IgG1 is a critical event in disease progression. Polyclonal IgG1, IgG3, and IgE antibodies also showed significant elevation (P < 0.05) in patients compared with EC. A strong correlation (rho = 0.254; P < 0.003) was observed between M. tuberculosis-specific IgG1 and polyclonal IgG1 in patients, suggesting that activations of antigen-specific and polyclonal antibodies are related events. No correlation was found between IgG1 antibodies and purified protein derivative skin test results. Since IgG1 antibody responses to culture filtrate are present only after disease establishment, IgG1 responses could provide a useful diagnostic marker of disease.

The Health Belief Model As A Predictor Of Gynecological Exams: Does Sexual Orientation Matter?, Lynn Elizabeth Kunkel

Dissertations and Theses

Screening and early detection are essential for the management and control of most diseases. It is important for women to practice routine health care that includes both clinical and self examinations. Today, many women go without health care due to barriers which prevent them from obtaining adequate care. The present study was designed to investigate, using the Health Belief Model, whether there is a difference between heterosexual and lesbian women in obtaining gynecological exams. Responses from 238 participants, 70 heterosexuals and 168 lesbians, indicated that the Health Belief Model was a significant predictor of whether women complied with recommended guidelines …

Identification And Characterization Of Mitochondrial Dna Variants In Alzheimer's Disease, Natasha Singh Hamblet

Theses and Dissertations in Biomedical Sciences

Alzheimer's Disease (AD) is a complex neurodegenerative disorder that affects a significant portion of the human population regardless of ethnicity or gender. A mitochondrial hypothesis of AD has been proposed based on a number of studies which establish altered oxidative phosphorylation (OXPHOS) and ATP synthesis in AD tissue. ATP demand is most prevalent in the brain; damage to OXPHOS could severely impair brain metabolism, thereby leading to a decline in cognitive function. Four out of five complexes in the OXPHOS pathway are partly encoded by mitochondrial DNA (mtDNA); thus, this may be a crucial site of lesions that alter brain …

Predicting Intentions Of Physical Therapy Students To Practice Primary Prevention, Sharon Potter Anderson

Loma Linda University Electronic Theses, Dissertations & Projects

Physical therapy (PT) has traditionally been a hands-on, tertiary-care field. Although the American Physical Therapy Association has mandated a broader perspective, little primary prevention is yet being reported in the U. S. An attitude change toward prevention must occur if physical therapists can be expected to become involved in preventive physical therapy. The purpose of this project was to determine predictors of physical therapy student intention to perform primary prevention with a questionnaire based on Ajzen's Theory of Planned Behavior. The theory uses attitude, subjective norm and perceived control to predict intention based on beliefs and strength of beliefs in …

Persistent Oral Dyskinesias Induced By Long-Term Haloperidol Treatment Is Dissociated From Changes In Neostriatal B(Max) And Mrna Content For Dopamine D(2) Receptors, Nuoyu Huang

Electronic Theses and Dissertations

Due to the presumed associations of dopamine (DA) receptor supersensitivity phenomena in both long-term neuroleptic-treated tardive dyskinetic rats and neonatal 6-hydroxydopamine (n6-OHDA)-lesioned rats, we studied the influence of haloperidol on n6-OHDA-lesioned rats. At 3 days after birth rats received 6-OHDA-HBr (200 $\mu$g, bilateral intracerebroventricularly; desipramine pretreatment, 20 mg/kg, 1h) or vehicle. Two months later haloperidol (1.5/kg/day $\times$ 2 days/week for 4 weeks, then 1.5 mg/kg/day, every day for 10 months) was added to the drinking water. Spontaneous oral activity of intact and n6-OHDA-lesioned rats receiving haloperidol was reached and maintained at significantly higher levels after 15 weeks of haloperidol treatment. …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1995), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1995 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Joining a Distinguished Few: Lester Eisenberg, DO, ‘38
• Alumni Association Certificate of Honor Recipients
• Founders Day is Another ''Classy" Reunion!
• Spirits Ride High at 99th Annual AOA Convention
• Students Make PCOM Proud
• PCOM Profile: James H. Black, DO
• Campus Update
• Just Published
• Class Acts
• In Memoriam
• Coming Events
• Phi Sig Fraternity Inducts Honorary Members

Cerebral Vascular Accidents And Therapeutic Treatments, Allison L. Hartman

Presidential Scholars Theses (1990 – 2006)

A cerebral vascular accident (CVA) is commonly referred to as a stroke. Stroke is the third leading cause of death and the number one cause of serious disability in the United States. Approximately 550,000 people suffer a stroke each year; 150,000 of these result in death. Each stroke is unique. After a stroke, some victims will suffer severe deficits and/or permanent disability for the remainder of their lives. Yet other victims may suffer only mild, temporary deficits and may recover completely. Currently over three million Americans are living with the effects of stroke . Most of these individuals have been …

Loss Of The Tumor Suppressor Genes P53 And Brca1 In Prophylactic Mastectomy Cancer Patients, Garrett Griffith Losh

Presidential Scholars Theses (1990 – 2006)

More importantly, this study has shown that prophylactic mastectomy surgery is a viable and worthwhile treatment to prevent breast cancer recurrence. It is hoped that this information will increase the knowledge of breast cancer. For the same reason, this paper has attempted to explain what cancer is while describing how the genetics of a person cause or contribute to its development. Most of all, it is hoped that this paper will emphasize the severity of this disease in the United States today and tomorrow .

A Phenomenological Study Of Infertility : The Couple's Perspective, M. Imeson

Theses: Doctorates and Masters

The purpose of this phenomenological study was to describe and interpret the experience of infertility from the perspective of infertile couples, in order to gain an in-depth understanding of how it affects their lives. Ten to twenty per cent of the global population share the experience of infertility, however, little is known of their experiences and perceptions related to infertility. Literature to date mainly focuses on the physiological effects of infertility and does not take into account the context in which the experience takes place, or the meanings that people assign to this experience. To be effective, health carers need …

Long Term Restoration Of Peak Torque, Endurance And Muscle Activation Post Anterior Cruciate Ligament Reconstruction, Darryl Alan Turner

Theses : Honours

In recent years, Accelerated Rehabilitation (A.R.) protocols have been used following Anterior Cruciate Ligament (A.C.L.) reconstructions, the longer term effects of these programs are seldom analysed. This study examined musculoskeletal mechanisms that might affect long term functional restoration, the control subjects (n = 19) of mixed age and gender, had no previous knee deficiencies and were recreationally fit. The experimental subjects (n = 17) had undergone intra-articular A.C.L reconstruction, using bone patellar-tendon bone grafts performed by the same surgeon and had also participated in the A.R. protocol, similar to that described by Shelbourne and Nitz (1990). The experimental group attended …