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Combination Of Dasatinib With Chemotherapy In Previously Untreated Core Binding Factor Acute Myeloid Leukemia: Calgb 10801, G. Marcucci, S. Geyer, K. Laumann, W. Zhao, D. Bucci, G. L. Uy, W. Blum, A. K. Eisfeld, J. E. Kolitz, R. A. Larson, +7 Additional Authors
Combination Of Dasatinib With Chemotherapy In Previously Untreated Core Binding Factor Acute Myeloid Leukemia: Calgb 10801, G. Marcucci, S. Geyer, K. Laumann, W. Zhao, D. Bucci, G. L. Uy, W. Blum, A. K. Eisfeld, J. E. Kolitz, R. A. Larson, +7 Additional Authors
Journal Articles
© 2020 by The American Society of Hematology. Acutemyeloid leukemia (AML)witheither t(8;21)(q22;q22)or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%. Mutated (mut) or overexpressed KIT, a gene encoding a receptor tyrosine kinase, has been found almost exclusively in CBF AML and may increase the risk of disease relapse. We tested the safety and clinical activity of dasatinib, a multi-kinase inhibitor, in combination with chemotherapy. Sixty-one adult patients with AML and CBF fusion transcripts (RUNX1/RUNX1T1 or CBFB/MYH11) were enrolled on Cancer and Leukemia Group …
Pulmonary Artery Aneurysm: A Review, M. Gupta, A. Agrawal, A. Iakovou, S. Cohen, R. Shah, A. Talwar
Pulmonary Artery Aneurysm: A Review, M. Gupta, A. Agrawal, A. Iakovou, S. Cohen, R. Shah, A. Talwar
Journal Articles
No abstract provided.
Mir193a Modulation And Podocyte Phenotype, A. Jha, S. Saha, K. Ayasolla, H. Vashistha, A. Malhotra, K. Skorecki, P. C. Singhal
Mir193a Modulation And Podocyte Phenotype, A. Jha, S. Saha, K. Ayasolla, H. Vashistha, A. Malhotra, K. Skorecki, P. C. Singhal
Journal Articles
Apolipoprotein L1 (APOL1)-miR193a axis has been reported to play a role in the maintenance of podocyte homeostasis. In the present study, we analyzed transcription factors relevant to miR193a in human podocytes and their effects on podocytes' molecular phenotype. The motif scan of the miR193a gene provided information about transcription factors, including YY1, WT1, Sox2, and VDR-RXR heterodimer, which could potentially bind to the miR193a promoter region to regulate miR193a expression. All structure models of these transcription factors and the tertiary structures of the miR193a promoter region were generated and refined using computational tools. The DNA-protein complexes of the miR193a promoter …
Famotidine Use Is Associated With Improved Clinical Outcomes In Hospitalized Covid-19 Patients: A Propensity Score Matched Retrospective Cohort Study., D. E. Freedberg, J. Conigliaro, T. C. Wang, K. J. Tracey, M. V. Callahan, J. A. Abrams, Famotidine Research Group Famotidine Research Grou, M. E. Sobieszczyk, D. D. Markowitz, A. Gupta, M. R. O'Donnell, J. Li, D. A. Tuveson, Z. Jin, W. C. Turner, D. W. Landry
Famotidine Use Is Associated With Improved Clinical Outcomes In Hospitalized Covid-19 Patients: A Propensity Score Matched Retrospective Cohort Study., D. E. Freedberg, J. Conigliaro, T. C. Wang, K. J. Tracey, M. V. Callahan, J. A. Abrams, Famotidine Research Group Famotidine Research Grou, M. E. Sobieszczyk, D. D. Markowitz, A. Gupta, M. R. O'Donnell, J. Li, D. A. Tuveson, Z. Jin, W. C. Turner, D. W. Landry
Journal Articles
No abstract provided.
The Uses Of Overnight Pulse Oximetry, S. Singh, S. Khan, D. Singh, S. Verma, A. Talwar
The Uses Of Overnight Pulse Oximetry, S. Singh, S. Khan, D. Singh, S. Verma, A. Talwar
Journal Articles
© 2020 Indian Chest Society Published by Wolters Kluwer - Medknow. Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel polysomnography for detecting sleep-disordered breathing. It provides accurate information about patient's oxygenation status and also helps in monitoring the response to continuous positive airway pressure and in the surgical treatment of obstructive sleep apnea (OSA). Nocturnal hypoxemia portends a …
Covid-19: Magnifying The Effect Of Health Disparities, E. J. Kim, L. Marrast, J. Conigliaro
Covid-19: Magnifying The Effect Of Health Disparities, E. J. Kim, L. Marrast, J. Conigliaro
Journal Articles
No abstract provided.
Obstructive Lung Disease Secondary To Compression Of The Bronchus By An Enlarged Pulmonary Artery, J. Panthappattu, V. Sharma, S. Verma, A. Talwar
Obstructive Lung Disease Secondary To Compression Of The Bronchus By An Enlarged Pulmonary Artery, J. Panthappattu, V. Sharma, S. Verma, A. Talwar
Journal Articles
© 2020 Indian Chest Society Published by Wolters Kluwer - Medknow. In clinical practice, the presence of wheezing generally indicates an airway disease. In rare circumstances, adjacent mediastinal structures may compress the tracheobronchial tree leading to obstructive physiology. Compression of the tracheobronchial region by an enlarged pulmonary artery (PA) is exceedingly rare. We present here a case of pulmonary hypertension, where the enlarged PA resulted in obstructive lung physiology with a relevant review of the literature.
A Case Of Plasmodium Falciparum Malaria With A Prolonged Incubation Period Of Four Years., E. Sleiman, A. Upadhyaya, A. Glaser, M. Krzyzak
A Case Of Plasmodium Falciparum Malaria With A Prolonged Incubation Period Of Four Years., E. Sleiman, A. Upadhyaya, A. Glaser, M. Krzyzak
Journal Articles
With increased global travel, unique diseases from different parts of the world pose a new category of differential diagnosis, and an incubation period of different infectious diseases helps narrow differential diagnosis to point to one specific etiology. The normal incubation period of Plasmodium falciparum malariais 7-40 days. We report a case of symptomatic P. falciparum malaria that manifested four years after a visit to a malaria-endemic area in a 51-year-old female patient. Our case illustrates the importance of a broad differential with regard to infectious disease including remote travel history and raises questions of the survival of P. falciparum for …
Pulmonary Artery Dilatation And Obstructive Sleep Apnea, J. Simonson, H. Greenberg, A. Talwar
Pulmonary Artery Dilatation And Obstructive Sleep Apnea, J. Simonson, H. Greenberg, A. Talwar
Journal Articles
No abstract provided.
Inflammation And Erythropoiesis-Stimulating Agent Hyporesponsiveness: A Critical Connection, H. H. Shah, N. N. Uppal, S. Fishbane
Inflammation And Erythropoiesis-Stimulating Agent Hyporesponsiveness: A Critical Connection, H. H. Shah, N. N. Uppal, S. Fishbane
Journal Articles
No abstract provided.
Peri-Transplant Management Of Nonalcoholic Fatty Liver Disease In Liver Transplant Candidates, N. S. Samji, R. Heda, S. K. Satapathy
Peri-Transplant Management Of Nonalcoholic Fatty Liver Disease In Liver Transplant Candidates, N. S. Samji, R. Heda, S. K. Satapathy
Journal Articles
© Translational Gastroenterology and Hepatology. All rights reserved. The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly growing, affecting 25% of the world population. Non-alcoholic steatohepatitis (NASH) is the most severe form of NAFLD and affects 1.5% to 6.5% of the world population. Its rising incidence will make end-stage liver disease (ESLD) due to NASH the number one indication for liver transplantation (LT) in the next 10 to 20 years, overtaking Hepatitis C. Patients with NASH also have a high prevalence of associated comorbidities such as type 2 diabetes, obesity, metabolic syndrome, cardiovascular disease, and chronic kidney disease (CKD), …
Tissue Plasminogen Activator (Tpa) Treatment For Covid-19 Associated Acute Respiratory Distress Syndrome (Ards): A Case Series, J. Wang, N. Hajizadeh, E. E. Moore, R. C. Mcintyre, P. K. Moore, L. A. Veress, M. B. Yaffe, H. B. Moore, C. D. Barrett
Tissue Plasminogen Activator (Tpa) Treatment For Covid-19 Associated Acute Respiratory Distress Syndrome (Ards): A Case Series, J. Wang, N. Hajizadeh, E. E. Moore, R. C. Mcintyre, P. K. Moore, L. A. Veress, M. B. Yaffe, H. B. Moore, C. D. Barrett
Journal Articles
This article is protected by copyright. All rights reserved. A hallmark of severe COVID-19 is coagulopathy, with 71.4% of patients who die of COVID-19 meeting ISTH criteria for disseminated intravascular coagulation (DIC) while only 0.6% of patients who survive meet these criteria (1). Additionally, it has become clear that this is not a bleeding diathesis but rather a predominantly pro-thrombotic DIC with high venous thromboembolism rates, elevated D-dimer levels, high fibrinogen levels in concert with low anti-thrombin levels, and pulmonary congestion with microvascular thrombosis and occlusion on pathology in addition to mounting experience with high rates of central line thrombosis …
Preparation In The Big Apple: New York City, A New Epicenter Of The Covid-19 Pandemic, S. A. Gross, D. H. Robbins, D. A. Greenwald, F. H. Schnoll-Sussman, M. B. Pochapin
Preparation In The Big Apple: New York City, A New Epicenter Of The Covid-19 Pandemic, S. A. Gross, D. H. Robbins, D. A. Greenwald, F. H. Schnoll-Sussman, M. B. Pochapin
Journal Articles
No abstract provided.
Covid-19 Therapeutic Options For Patients With Kidney Disease, H. Izzedine, K. D. Jhaveri, M. A. Perazella
Covid-19 Therapeutic Options For Patients With Kidney Disease, H. Izzedine, K. D. Jhaveri, M. A. Perazella
Journal Articles
No abstract provided.
Use Of Omental Patch And Endoscopic Closure Technique As An Alternative To Surgery After Endoscopic Full Thickness Resection Of Gastric Intestinal Stromal Tumors: A Series Of Cases, A. H. Sachdev, S. Iqbal, I. B. Ribeiro, D. T. De Moura
Use Of Omental Patch And Endoscopic Closure Technique As An Alternative To Surgery After Endoscopic Full Thickness Resection Of Gastric Intestinal Stromal Tumors: A Series Of Cases, A. H. Sachdev, S. Iqbal, I. B. Ribeiro, D. T. De Moura
Journal Articles
© The Author(s) 2020. BACKGROUND Gastrointestinal stromal tumors (GISTs) originate from interstitial cells of Cajal. GISTs can occur anywhere along the gastrointestinal tract. Large lesions have traditionally been removed surgically. However, with recent innovations in advanced endoscopy, GISTs located within the stomach are now removed endoscopically. We describe a new innovative endoscopic technique to close large and hard to access defects after endoscopic full-thickness resection of gastric GISTs. CASE SUMMARY We present a series of three patients who were diagnosed with a gastric GIST. All patients underwent full-thickness endoscopic resection. In all cases, for closure of the surgical bed, conventional …
External Validation Of A Venous Thromboembolic Risk Score For Cancer Outpatients With Solid Tumors: The Compass-Cat Venous Thromboembolism Risk Assessment Model, A. C. Spyropoulos, J. B. Eldredge, L. N. Anand, M. Zhang, M. Qiu, S. Nourabadi, D. J. Rosenberg
External Validation Of A Venous Thromboembolic Risk Score For Cancer Outpatients With Solid Tumors: The Compass-Cat Venous Thromboembolism Risk Assessment Model, A. C. Spyropoulos, J. B. Eldredge, L. N. Anand, M. Zhang, M. Qiu, S. Nourabadi, D. J. Rosenberg
Journal Articles
No abstract provided.
Hospital-Based Use Of Thromboprophylaxis In Patients With Covid-19, A. C. Spyropoulos, W. Ageno, E. S. Barnathan
Hospital-Based Use Of Thromboprophylaxis In Patients With Covid-19, A. C. Spyropoulos, W. Ageno, E. S. Barnathan
Journal Articles
No abstract provided.
Post-Discharge Prophylaxis With Rivaroxaban Reduces Fatal And Major Thromboembolic Events In Medically Ill Patients, A. C. Spyropoulos, W. Ageno, G. W. Albers, C. G. Elliott, J. L. Halperin, W. R. Hiatt, G. A. Maynard, P. G. Steg, J. I. Weitz, G. E. Raskob, +3 Additional Authors
Post-Discharge Prophylaxis With Rivaroxaban Reduces Fatal And Major Thromboembolic Events In Medically Ill Patients, A. C. Spyropoulos, W. Ageno, G. W. Albers, C. G. Elliott, J. L. Halperin, W. R. Hiatt, G. A. Maynard, P. G. Steg, J. I. Weitz, G. E. Raskob, +3 Additional Authors
Journal Articles
© 2020 The Authors Background: Hospitalized acutely ill medical patients are at risk for fatal and major thromboembolic events. Whether use of extended-duration primary thromboprophylaxis can prevent such events is unknown. Objectives: The purpose of this study was to evaluate whether extended-duration rivaroxaban reduces the risk of venous and arterial fatal and major thromboembolic events without significantly increasing major bleeding in acutely ill medical patients after discharge. Methods: MARINER (A Study of Rivaroxaban [JNJ-39039039] on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients) studied acutely ill medical patients with additional risk factors for venous thromboembolism (VTE). Medically ill patients with …
Inaccurate Conclusions By Tang And Colleagues, Y. Y. Greenstein
Inaccurate Conclusions By Tang And Colleagues, Y. Y. Greenstein
Journal Articles
No abstract provided.
Erratum: What Is The Source? Identifying The Cause Of Septic Shock In A Patient (Annals Of The American Thoracic Society (2020) 17 (236-239) Doi: 10.1513/Annalsats.201907-562cc), N. Sidhu, N. U. Baloch, Y. Greenstein
Erratum: What Is The Source? Identifying The Cause Of Septic Shock In A Patient (Annals Of The American Thoracic Society (2020) 17 (236-239) Doi: 10.1513/Annalsats.201907-562cc), N. Sidhu, N. U. Baloch, Y. Greenstein
Journal Articles
Copyright © 2020 by the American Thoracic Society. The authors would like to correct the author order in their article published in the February 2020 issue of AnnalsATS (1). The correct author order should be as follows: Nimrita Sidhu, Noor Ul-Ain Baloch, and Yonatan Greenstein. For the convenience of our readers, AnnalsATS is replacing the online version of the article with a corrected version; we apologize for the error.
Decreasing The Peril Of Antimicrobial Resistance Through Enhanced Health Literacy In Outpatient Settings: An Underrecognized Approach To Advance Antimicrobial Stewardship, E. D. Hermsen, E. L. Macgeorge, M. L. Andresen, L. M. Myers, C. J. Lillis, B. M. Rosof
Decreasing The Peril Of Antimicrobial Resistance Through Enhanced Health Literacy In Outpatient Settings: An Underrecognized Approach To Advance Antimicrobial Stewardship, E. D. Hermsen, E. L. Macgeorge, M. L. Andresen, L. M. Myers, C. J. Lillis, B. M. Rosof
Journal Articles
© 2020, The Author(s). Globally, antimicrobial resistance (AMR) is a serious problem causing 700,000 deaths annually. By 2050, AMR is expected to cause approximately 10 million deaths globally each year if allowed to increase at the present rate. Many individuals have limited knowledge regarding appropriate antibiotic use and AMR. Most antibiotic use occurs in the outpatient setting, with approximately 30% of antibiotics prescribed deemed unnecessary. Antimicrobial stewardship (AMS) is a means to reduce inappropriate antibiotic use and AMR. While existing AMS efforts generally focus on the inpatient setting, a significant gap is present in the outpatient setting. A common theme …
Guidelines To Reduce Hospitalization Rates For Patients Receiving Curative-Intent Radiation Therapy During The Covid-19 Pandemic: Report From A Multicenter New York Area Institution, Wc Chen, S Teckie, G Somerstein, N Adair, L Potters
Guidelines To Reduce Hospitalization Rates For Patients Receiving Curative-Intent Radiation Therapy During The Covid-19 Pandemic: Report From A Multicenter New York Area Institution, Wc Chen, S Teckie, G Somerstein, N Adair, L Potters
Journal Articles
No abstract provided.
Facing Covid-19 In The Icu: Vascular Dysfunction, Thrombosis, And Dysregulated Inflammation, De Leisman, Cs Deutschman, M Legrand
Facing Covid-19 In The Icu: Vascular Dysfunction, Thrombosis, And Dysregulated Inflammation, De Leisman, Cs Deutschman, M Legrand
Journal Articles
No abstract provided.
Reduction In St-Segment Elevation Cardiac Catheterization Laboratory Activations In The United States During Covid-19 Pandemic, S Garcia, Ms Albaghdadi, Pm Meraj, C Schmidt, R Garberich, Fa Jaffer, S Dixon, Jj Rade, M Tannenbaum, Td Henry, +2 Additional Authors
Reduction In St-Segment Elevation Cardiac Catheterization Laboratory Activations In The United States During Covid-19 Pandemic, S Garcia, Ms Albaghdadi, Pm Meraj, C Schmidt, R Garberich, Fa Jaffer, S Dixon, Jj Rade, M Tannenbaum, Td Henry, +2 Additional Authors
Journal Articles
No abstract provided.
Living With Covid-19: A Perspective From New York Area Ophthalmology Residency Program Directors At The Epicenter Of The Pandemic, Rw Chen, A Abazari, S Dhar, Dr Fredrick, Ib Friedman, Lr Dagi Glass, As Khouri, Et Kim, J. Laudi, J Winokur, +6 Additional Authors
Living With Covid-19: A Perspective From New York Area Ophthalmology Residency Program Directors At The Epicenter Of The Pandemic, Rw Chen, A Abazari, S Dhar, Dr Fredrick, Ib Friedman, Lr Dagi Glass, As Khouri, Et Kim, J. Laudi, J Winokur, +6 Additional Authors
Journal Articles
No abstract provided.
Management Of Lung Nodules And Lung Cancer Screening During The Covid-19 Pandemic: Chest Expert Panel Report, Pj Mazzone, Mk Gould, Da Arenberg, Ac Chen, Hk Choi, Fc Detterbeck, F Farjah, Km Fong, S Raoof, Ga Silvestri, +14 Additional Authors
Management Of Lung Nodules And Lung Cancer Screening During The Covid-19 Pandemic: Chest Expert Panel Report, Pj Mazzone, Mk Gould, Da Arenberg, Ac Chen, Hk Choi, Fc Detterbeck, F Farjah, Km Fong, S Raoof, Ga Silvestri, +14 Additional Authors
Journal Articles
No abstract provided.
Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar, Rb Liu, Vs Tayal, Nl Panebianco, Y Tung-Chen, A Nagdev, S Shah, E Pivetta, Pc Henwood, Mj Nelson, Cl Moore
Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar, Rb Liu, Vs Tayal, Nl Panebianco, Y Tung-Chen, A Nagdev, S Shah, E Pivetta, Pc Henwood, Mj Nelson, Cl Moore
Journal Articles
No abstract provided.
Response To Sars-Covid-19-Related Visitor Restrictions On Labor And Delivery Wards In New York City, A Hermann, Km Deligiannidis, V Bergink, C Monk, Em Fitelson, Tk Robakis, C Birndorf
Response To Sars-Covid-19-Related Visitor Restrictions On Labor And Delivery Wards In New York City, A Hermann, Km Deligiannidis, V Bergink, C Monk, Em Fitelson, Tk Robakis, C Birndorf
Journal Articles
No abstract provided.
The Covid-19 Pandemic: Experiences Of A Geriatrician-Hospitalist Caring For Older Adults, L Sinvani
The Covid-19 Pandemic: Experiences Of A Geriatrician-Hospitalist Caring For Older Adults, L Sinvani
Journal Articles
No abstract provided.
Telemedicine For Outpatient Neurosurgical Oncology Care: Lessons Learned For The Future During The Covid-19 Pandemic., Lc Daggubati, Dg Eichberg, Me Ivan, S Hanft, A Mansouri, Rj Komotar, Rs D'Amico, Be Zacharia
Telemedicine For Outpatient Neurosurgical Oncology Care: Lessons Learned For The Future During The Covid-19 Pandemic., Lc Daggubati, Dg Eichberg, Me Ivan, S Hanft, A Mansouri, Rj Komotar, Rs D'Amico, Be Zacharia
Journal Articles
No abstract provided.