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Beta-Adrenergic, Arachidonic Acid And Potassium Channel Associated-Regulation Of Human Breast Cancer Cell Lines, Yavuz Cakir
Beta-Adrenergic, Arachidonic Acid And Potassium Channel Associated-Regulation Of Human Breast Cancer Cell Lines, Yavuz Cakir
Doctoral Dissertations
During the late stages of breast cancer progression, breast cancer cell growth switches from steroid hormone to growth factor dependence, and it is assumed that invasive breast cancers are growth factor receptor positive and estrogen hormone resistant. The cellular arachidonic acid (AA) pathway is upregulated in a variety of cancer types, and it may play an important role in the growth regulation of breast cancer cells.
Recent evidence suggests that beta-adrenergic receptors (β-ARs) are expressed in some estrogen receptor (ER) negative breast cancers and that beta agonists not only can trigger AA release via the activation of cytosolic PLA2 or …