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Celecoxib Decreases Prostaglandin E2 Concentrations In Nipple Aspirate Fluid From High Risk Postmenopausal Women And Women With Breast Cancer, Edward R. Sauter, Wenyi Quin, Lisa Schlatter, John E. Hewett, John T. Flynn

Department of Molecular Physiology and Biophysics Faculty Papers

Background

Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily (bid). The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer.

Methods

NAF and plasma samples were collected before, 2 weeks after taking celecoxib 400 mg bid, and two weeks after washout from 26 women who …

3,3′-Diindolylmethane And Paclitaxel Act Synergistically To Promote Apoptosis In Her2/Neu Human Breast Cancer Cells, Kandace P. Mcguire, N. Ngoubilly, M. Neavyn, Susan Lanza-Jacoby

Department of Surgery Faculty Papers

Background. HER2/neu positive breast tumors are difficult to treat. About 25 to 30% of invasive breast tumors overexpress the HER2/neu oncogene. These tumors are aggressive and become resistant to chemotherapeutic drugs. 3,3′-diindolylmethane (DIM), the active metabolite of indole-3-carbinol, a naturally occurring compound found in cruciferous vegetables, has been found to have anti-cancer properties in both humans and animals. DIM has been shown to induce cell cycle arrest and apoptosis in animal breast cancer models. Because HER2/neu overexpression confers resistance to paclitaxel, and DIM has anti-tumor effects, we hypothesized that DIM will enhance the cytotoxic effects of paclitaxel, a common …