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Snpredict: A Machine Learning Approach For Detecting Low Frequency Variants In Cancer, Vatsal Mehra
Snpredict: A Machine Learning Approach For Detecting Low Frequency Variants In Cancer, Vatsal Mehra
Master's Theses (2009 -)
Cancer is a genetic disease caused by the accumulation of DNA variants such as single nucleotide changes or insertions/deletions in DNA. DNA variants can cause silencing of tumor suppressor genes or increase the activity of oncogenes. In order to come up with successful therapies for cancer patients, these DNA variants need to be identified accurately. DNA variants can be identified by comparing DNA sequence of tumor tissue to a non-tumor tissue by using Next Generation Sequencing (NGS) technology. But the problem of detecting variants in cancer is hard because many of these variant occurs only in a small subpopulation of …
Rna-Seq Analysis Of Localized Mst1/Stk4 Expression In Prostate Cancer, Damien Ready
Rna-Seq Analysis Of Localized Mst1/Stk4 Expression In Prostate Cancer, Damien Ready
Master's Theses (2009 -)
The SKT4-encoded MST1 is a serine-threonine protein kinase and has known associations with many diseases and cancer.MST1 plays a critical component of the Hippo tumor suppressor pathway responsible for limiting cell division and promoting apoptosis.Loss of MST1 function is associated with poor prognostic outcomes for cancers, though the mechanism is not well understood.There is increasing evidence that dysregulation of MST1 can lead to castration-resistant prostate cancer (CRPCa), an aggressive cancer with limited treatment options.To better understand the mechanistic underpinnings of CRPCa progression, C4-2 prostate cancer cells were engineered toexpress MST1 protein directed to a particular subcellular region: membrane, nucleus, or …
Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra
Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra
Master's Theses (2009 -)
Cognitive abilities decline as part of the normal aging process. Various non-pharmacological interventions are being studied in an effort to ameliorate this cognitive decline. Some of these interventions include computerized cognitive training, such as neuropsychological software (i.e., brain training games) and video games. A previous study in our lab found that older adults who played a brain training game or a video poker game showed similar cognitive gains. The purpose of the present study was to follow the methodological procedures of our previous study to try and determine if the positive effects seen for the brain training program and video …