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The Effects Of Low Protein During Gestation On Mouse Pancreas Development And Beta Cell Regeneration, Aaron R. Cox
The Effects Of Low Protein During Gestation On Mouse Pancreas Development And Beta Cell Regeneration, Aaron R. Cox
Electronic Thesis and Dissertation Repository
Effects of a low protein (LP) diet during gestation on the metabolism of rat offspring have been well characterized and leads to glucose intolerance in adulthood. It is unknown how LP impacts endocrine pancreas development in the mouse, or whether this affects future β-cell plasticity. Streptozotocin (STZ) – induced β-cell injury has been demonstrated to be followed by β-cell regeneration in young animals, but the mechanism(s) of regeneration are not clear. Our objective was to characterize a mouse model of maternal LP, in addition to identifying factors that contribute to the long term development of glucose intolerance and the mechanism …
Δnp63 Regulates A Complex Network Of Target Genes In Limb And Epidermal Development, Min Soon Cho
Δnp63 Regulates A Complex Network Of Target Genes In Limb And Epidermal Development, Min Soon Cho
Dissertations & Theses (Open Access)
The skin is composed of two major compartments, the dermis and epidermis. The epidermis forms a barrier to protect the body. The stratified epithelium has self-renewing capacity throughout life, and continuous turnover is mediated by stem cells in the basal layer. p63 is structurally and functionally related to p53. In spite of their structural similarities, p63 is critical for the development and maintenance of stratified epithelial tissues, unlike p53. p63 is highly expressed in the epidermis and previously has been shown to play a critical role in the development and maintenance of the epidermis. The study of p63 has been …