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Intouch Week Of June 24, 2024, New York Medical College

InTouch

• Teeing Off for Tomorrow’s Scholars at the Golf Outing
• New Medical School Linkage Agreement for GSBMS Students
• Dr. Halperin Offers Thoughts on the American Hearing Aid Market
• Scarring Persists in Patients with COVID-19 Vaccine-Associated Myocarditis
• Study Suggests Diagnostic Surgery Can Be Used Safely on Children with Epilepsy
• Department Spotlight: The Office of Government Affairs Advances the College’s Mission, Education, and Research
• Alumni Spotlight: Dr. Mboge Plants Seeds of Change from The Gambia to New York

Evolution Of Global Anatomy Research Through Covid-19: A Post-Pandemic Evaluation, Harsh Chheda, Santanu De

FDLA Journal

The Coronavirus Infectious Disease 2019 (COVID-19) struck the world with a deep impact on many countries' healthcare systems. More specifically, anatomical research experienced a drastic setback due to the limitations and restrictions placed upon them by the medical community. This study aims to review how COVID-19 guidelines presented conflict regarding the retrieval and use of cadavers, as well as how anatomy research was modified on a global scale owing to the pandemic. The COVID-19 outbreak called for several changes upon each significant anatomical research technique, ranging from cadaver dissection to diagnostic imaging. Given the remarkable shift in medical research guidelines …

Modificaciones Realizadas En Cirugías Y En Cuidados De Pacientes En Ecuador, Addison Wolfe

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

Exploring The Genetics Of Myotonic Dystrophy Type 1 And Its Ethical Implications, Caleb Smith

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

Efficacy And Safety Of Bempedoic Acid As A Treatment Option For Hyperlipidemia: A Systematic Review, Muhammad Hammad Sharif, Abdullah A. Orakzai, Madeeha Khaleeque, Syeda Sarah Raza, Osama Sherjeel Khan, Muhammad Hassan Jan, Atif Ahmed, Muhammad Arsalan

Advances in Clinical Medical Research and Healthcare Delivery

Introduction:

Bempedoic acid (BA) is an inhibitor of ATP-citrate lyase (ACL) and is used in the treatment of hyperlipidemia by inhibiting cholesterol synthesis. Randomized clinical trials (RCTs) have shown the efficacy of BA in lowering LDL-C levels and it is currently approved as a treatment option for patients with hyperlipidemia to achieve target LDL-C levels. We conducted a systematic review to further elucidate the efficacy and safety profile of BA in patients with hyperlipidemia.

Methods:

We searched the electronic database Medline, Embase, and Cochrane Library for RCTs between 2013 and 2023. We used keywords (“Bempedoic Acid”) AND (“Hypercholesterolemia”) AND (“Lipid …

A Single-Center, Assessor-Blinded, Randomized Controlled Clinical Trial To Test The Safety And Efficacy Of A Novel Brain-Computer Interface Controlled Functional Electrical Stimulation (Bci-Fes) Intervention For Gait Rehabilitation In The Chronic Stroke Population, Piyashi Biswas, Lucy Dodakian, Po T. Wang, Christopher A. Johnson, Jill See, Vicky Chan, Cathy Chou, Wendy Lazouras, Alison L. Mckenzie, David J. Reinkensmeyer, Danh V. Nguyen, Steven C. Cramer, An H. Do, Zoran Nenadic

Physical Therapy Faculty Articles and Research

Background

In the United States, there are over seven million stroke survivors, with many facing gait impairments due to foot drop. This restricts their community ambulation and hinders functional independence, leading to several long-term health complications. Despite the best available physical therapy, gait function is incompletely recovered, and this occurs mainly during the acute phase post-stroke. Therapeutic options are limited currently. Novel therapies based on neurobiological principles have the potential to lead to long-term functional improvements. The Brain-Computer Interface (BCI) controlled Functional Electrical Stimulation (FES) system is one such strategy. It is based on Hebbian principles and has shown promise …

How To Mitigate The Risks Of Deployment Of Artificial Intelligence In Medicine?, Sevi̇l Uygun İli̇khan, Mahmut Özer, Hande Tanberkan, Veysel Bozkurt

Turkish Journal of Medical Sciences

The aim of this study is to examine the risks associated with the use of artificial intelligence (AI) in medicine and to offer policy suggestions to reduce these risks and optimize the benefits of AI technology. Artificial intelligence is a multifaceted technology. If harnessed effectively, it has the capacity to significantly impact the future of humanity in the field of health, as well as in several other areas. However, the rapid spread of this technology also raises significant ethical, legal, and social issues. This study examines the potential dangers of AI integration in medicine by reviewing current scientific work and …

Impact Of Celiac Disease In Behçet’S Syndrome Patients: A Study Based On The Database Of Türkiye, Nuray Yilmaz Çakmak, Nai̇m Ata, Serdar Can Güven, Emi̇n Gemci̇oğlu, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇

Turkish Journal of Medical Sciences

Background/Aim Our primary aim was to investigate the effects of concomitant celiac disease (CD) on the clinical characteristics of Behçet’s syndrome (BS) patients. Materials and method The study was a retrospective, nationwide, multi-center study. Turkish Ministry of Health National Electronic Database (e-Nabız) is used under Health Ministry's supervision to extract the subject's data. Statistical Analysis Statistical analyses were made by the Statistical Package for Social Sciences (SPSS) software version 20 (IBM Corp., Armonk, New York). Continuous variables were presented by mean ± standard derivation (SD) or median (min–max) according to normality and compared by student-T test. Results A total of …

The Effect Of Phototherapy Treatment On Serum Melatonin Levels In Term Newborns, Ali̇ Bülbül, İlkay Özmeral Odabaşi, Duygu Besni̇li̇ Açar, Semra Ti̇ryaki̇ Demi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the effect of phototherapy treatment on serum melatonin levels in term newborn infants. Material and methods: This study was planned as a single-center, prospective, observational, case-control study. Term infants (gestation week ≥37 weeks) who received at least 6 h of phototherapy due to jaundice constitute the phototherapy group, while the term infants without jaundice and who were exclusively breastfed constitute the control group. Melatonin levels were examined by taking blood samples from babies in both groups at 02:00 at night. Melatonin values were compared between groups. The effect of phototherapy on …

Evaluation Of The Results Of The Patients Who Underwent Plasmapheresis In The Pediatric Intensive Care Unit, Mehmet Nur Talay, Özhan Orhan, Murat Kanğin, Eşe Eda Turanli, Mehmet Nuri̇ Özbek

Turkish Journal of Medical Sciences

Background/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Yaşargil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients’ diagnosis, weight, type of procedure and type of …

Comparison Of Radiologic Findings Between Sars-Cov-2 And Other Respiratory Tract Viruses In Critically Ill Children During The Covid-19 Pandemic, Oktay Perk, Tanil Kendi̇rli̇, Emel Uyar, Bi̇rsel Şen Akova, Hati̇ce Albayrak, Hasan Ağin, Ebru Ati̇ke Ongun, Eşe Eda Turanli, Sare Güntülü Şik, Şahi̇n Si̇ncar, Gürkan Bozan, Demet Demi̇rkol, Nazan Ülgen Tekerek, Mey Tali̇p, Arzu Oto, Feyza İnceköy Gi̇rgi̇n, Ferhat Sari, Nuretti̇n Onur Kutlu, Altan Güneş, Ömer Suat Fi̇töz

Turkish Journal of Medical Sciences

Background/aim: This study was planned because the radiological distinction of COVID-19 and respiratory viral panel (RVP)-positive cases is necessary to prioritize intensive care needs and ensure non-COVID-19 cases are not overlooked. With that purpose, the objective of this study was to compare radiologic findings between SARS-CoV-2 and other respiratory airway viruses in critically ill children with suspected COVID-19 disease.Materials and methods: This study was conducted as a multicenter, retrospective, observational, and cohort study in 24 pediatric intensive care units between March 1 and May 31, 2020. SARS-CoV-2- or RVP polymerase chain reaction (PCR)-positive patients’ chest X-ray and thoracic computed tomography …

Total Kidney Volume In Autosomal Dominant Polycystic Kidney Disease: Intraobserver And Interobserver Agreement Of Two Methods With Mri, Eli̇f Gündoğdu, Çağatay Ci̇han, Celal Yazici

Turkish Journal of Medical Sciences

Background/aim: Total kidney volume (TKV) is a parameter used in both treatment decision and follow-up in autosomal dominant polycystic kidney disease (ADPKD) patients. The objective of this study was to evaluate intra- and interobserver agreement of the ellipsoid formula (EF) and manual boundary tracing method (MBTM) used in TKV measurement of ADPKD patients across different levels of experience radiologists. Additionally, the study aimed to evaluate the correlation between the EF and MBTM, which is considered the gold standard for TKV. Materials and methods: A retrospective evaluation was conducted on magnetic resonance imaging (MRI) data from 55 ADPKD patients who underwent …

Central Thromboxane A2, Prostaglandin F2Α, Prostaglandin E, And Prostaglandin D Contribute To The Cardiovascular Effects Elicited By Nesfatin-1, Gökçen Güvenç Bayram, Murat Yalçin

Turkish Journal of Medical Sciences

Background/aim: Our recent study revealed that the expression of lipoxygenase (LOX) and cyclooxygenase (COX) enzymes in the hypothalamus is activated by nesfatin-1, leading to the liberation of leukotrienes and prostaglandins (PG), respectively. Moreover, our prior report explained that intracerebroventricular (ICV) nesfatin-1 treatment triggers cardiovascular responses mediated by central LOX and COX enzymes. Building upon our prior reports, the present investigation sought to clarify the role of cardiovascularly active central COX products, such as thromboxane (TX) A2, PGF2α, PGE, and PGD, in orchestrating nesfatin-1-evoked reactions in mean arterial pressure (MAP) and heart rate (HR).Materials and methods: The Sprague Dawley rats, which …

Short- And Long-Term Neurological Outcomes Of Congenital Cytomegalovirus Infection, Fati̇h Mehmet Aki̇f Özdemi̇r, Yasemi̇n Taşci Yildiz, Rüveyda Gümüşer Ci̇nni̇, Ayşegül Zenci̇roğlu, Deni̇z Yüksel

Turkish Journal of Medical Sciences

Background/aim: Cytomegalovirus (CMV) is the most common congenital viral infection. Although most children with congenital CMV (approximately 85%–90%) are asymptomatic at birth, findings such as sensorineural hearing loss, microcephaly, and neurodevelopmental retardation can be observed during the follow-up. Among the brain magnetic resonance imaging (MRI) findings of CMV are white matter abnormalities, polymicrogyria, and periventricular calcification. Since a definitive diagnosis of congenital CMV cannot be made after the neonatal period, the identification of the associated phenotype is diagnostically important, but data are limited in patients who have been retrospectively diagnosed with congenital CMV infection. The aim of this study was …

Control Of Cardiometabolic Risk Factors And Their Association With Carotid Intima Media Thickness Among Patients With Type 2 Diabetes Mellitus-Single Center Experience In A Developing Country, Thilak Priyantha Weerarathna, Sarath Lekkamwasam, Iroshani Kodikara, Keddegoda Gamage Piyumi Wasana, Lakmal Fonseka

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes mellitus (T2DM) is closely associated with atherosclerotic cardiovascular diseases (ASCVD). The objective of this study was to describe the degree of ASCVD risk factor control and their association with carotid intima-media thickness (CIMT) in T2DM patients followed up at a diabetes clinic in Southern, Sri Lanka. Materials and methods: A crosssectional study was conducted to examine the association between CIMT and nonalcoholic fatty liver disease (NAFLD)in 300 T2DM patients. Both CIMT and its associations with modifiable cardiometabolic risk factors were examined using ultrasonography. The recommended optimal targets for risk factors were defined as glycated hemoglobin (HbA1C) …

Autism Spectrum Disorder: Evaluation Of Community-Based Screening Program, Mehmet Aki̇f Sezerol, Seli̇n Davun

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to evaluate the results of autism spectrum disorder (ASD) screenings conducted in a region of İstanbul between 2018 and 2023.Materials and methods: This descriptive study was conducted between April 2018 and February 2023 among 25,839 children aged between 18–36 months who had been screened for autism spectrum disorder in Sultanbeyli, İstanbul. Children between 18–36 months are examined and a form consisting of 5 questions and typical symptoms of ASD is filled. Each question is answered as yes or no. Answering yes to at least one of the questions is sufficient to direct them to child …

Changes In Blink Reflex After Simultaneous Supraorbital And Mental Nerve Stimulations In Healthy Subjects, Ayşegül Gündüz, Tuba Cerrahoğlu Şi̇ri̇n, Pinar Bekdi̇k Şi̇ri̇nocak, Tuba Akinci, Burcu Nuran Arkali, Fatma Candan, Meral E. Kiziltan

Turkish Journal of Medical Sciences

Background/aim: In this study, we investigated the blink reflex (BR) after simultaneous and asynchronous stimulation of two trigeminal nerve branches. The objective was to characterize the physiology of trigeminal and facial circuits.Materials and methods: We performed three sets of experiments: recording BR response i. after supraorbital nerve stimulation (SON), after mental nerve stimulation (MN), and after simultaneous SON and MN stimulation (SON+MN) in 18 healthy individuals; ii. after MN (at an intensity eliciting BR response) preceding SON at various interstimulus intervals (ISIs) in seven healthy subjects; iii after MN (at sensory threshold) preceding SON at various ISIs. We compared the …

Cross-Cultural Adaptation Of The Thoracic Outlet Syndrome Index For Turkish-Speaking Patients With Thoracic Outlet Syndrome, Hakki Çağdaş Basat, Fati̇h Özyurt, Muhammed İhsan Kodak, Gülşah Özsoy, Caner Kararti

Turkish Journal of Medical Sciences

Background/aim: Considering that there is no specifically designed scale to measure quality of life (QoL) and level of functioning among Turkish-speaking patients with thoracic outlet syndrome (TOS), the aim of this study was to adapt the Thoracic Outlet Syndrome Index (TOSI) to the Turkish language (TOSI-TR) and analyze its psychometric properties in patients with TOS. Materials and methods: Thirty-nine patients with symptomatic TOS were included in the study. The participants were assessed using the following measures: the QuickDASH, the Western Ontario Rotator Cuff Index (WORC), and a visual analog scale (VAS). The psychometric properties of the TOSI-TR were examined in …

Is Gut Microbiota Of Patients With Als Different From Healthy Ones?, Zeri̇n Özaydin Göksun, Seyda Erdoğan, Ayşe Kalkanci, Eli̇f Ayça Şahi̇n, Tuğba Çuhadar, H. Özden Şener

Turkish Journal of Medical Sciences

Background/aim: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Several studies shown that alterations of microbiota, increase the risk of neurodegenerative disorders. We aimed to reveal whether there is a difference in the gut microbiota of patients with ALS. Materials and methods: The participants are divided into three groups. Group 1 formed patients with ALS. Healthy family members living in the same house of the patients formed Group 2. Lastly, sex, age-matched healthy people were included in Group 3. Fecal samples were collected in 15 mL falcon tubes and stored at -80 °C. Genomic DNA isolation was performed on …

Patterns Of Longitudinal Subcortical Atrophy Over One Year In Amnestic Mild Cognitive Impairment And Its Impact On Cognitive Performance: A Preliminary Study, Berri̇n Çavuşoğlu, Duygu Hünerli̇, Derya Durusu Emek Savaş, Görsev Yener, Emel Ada

Turkish Journal of Medical Sciences

Background/aim: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia, and thus, it is of interest to enlighten specific brain atrophy patterns in aMCI patients. We aim to define the longitudinal atrophy pattern in subcortical structures and its effect on cognition in patients with aMCI.Materials and methods: Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB’s integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and …

Sting Activation Increases The Efficiency Of Temozolomide In Pten Harbouring Glioblastoma Cells, Zafer Yildirim, Eda Doğan, Hale Güler Kara, Buket Kosova, Vi̇ldan Bozok

Turkish Journal of Medical Sciences

Background/aim: Glioblastoma is one of the most aggressive tumours, resistant to all applied therapy regiments and prone to relapse. Median survival rates are therefore only expressed as months. STING agonists are immunomodulatory molecules that activate type I interferon expression, making them potentially useful in regulating the tumour microenvironment. Since PTEN serves as a critical phosphatase in activating interferon-regulating transcription factors and is frequently mutated in glioblastoma cells, this study aimed to investigate STING activation in glioblastoma cell lines, examining whether they harbour the PTEN protein or not.°Materials and methods: T98G and U118MG glioblastoma cell lines were treated with the 2ʹ3ʹ-c-di-AM(PS)2(Rp,Rp) …

Intouch Week Of June 10, 2024, New York Medical College

InTouch

• Kenneth Theobalds To Be Honored at NYMC’s Annual Golf Tournament
• NYMC Opens New Online Store
• Dylan Kwart, Ph.D., M.Sc., Presents at the Neighborhood Science Seminar Series
• NYMC Welcomes D.P.T. Class of 2027 at New Student Orientation
• Construction on the MEC Roadway
• Metropolitan Hospital Center Research Day Highlights NYMC Residents Work
• Socioeconomic Disparities Exist in Treatment of Teen Femoral Fractures
• Student Spotlight: SOM Student Harry Fruchtman Sheds Lights on New Cancer Treatments with Publications in Nature

The Brainstem As A Conserved System For Consciousness: Integrating Phylogeny, Neurology, And Psychology, Shadia Kawkabani, Kevin P. Kaut

Journal of Neuropsychology and Behavioral Processes

Historically, scientists and physicians have taken a corticocentric view of consciousness, emphasizing the need for a cortex in producing the conscious experience. The preserved consciousness observed in hydranencephalic children and decorticated rats suggests that some form of consciousness may be produced by a subcortical network. The brainstem, a phylogenetically conserved brain system, could serve as the major integrative network to produce this form of consciousness—referred to as ‘affective consciousness’, the evolutionary antecedent to the reflective consciousness allowing humans to reflect on experiences. The functional integration of the brainstem with the amygdala, motor network, and other subcortical structures provides the architecture …

Quantitative Proteomic Analysis Reveals Unique Hsp90 Cycle-Dependent Client Interactions, Erick I Rios, Davi Gonçalves, Kevin A Morano, Jill L Johnson

Journal Articles

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due to degradation of client proteins or indirect downstream effects. Due to its role in chaperoning oncogenic proteins, Hsp90 is an important drug target. However, compounds that occupy the ATP-binding pocket and broadly inhibit function have not achieved widespread use due to negative effects. More selective inhibitors are needed; however, it is unclear how to achieve selective inhibition. We conducted a quantitative proteomic analysis of soluble …

Postoperative Bioactive Adrenomedullin Is Associated With The Onset Of Ards And Adverse Outcomes In Patients Undergoing Open Thoracoabdominal Aortic Surgery, Panagiotis Doukas, Oliver Hartmann, Jelle Frankort, Birte Arlt, Hanif Krabbe, Michael Johan Jacobs, Andreas Greiner, Jan Paul Frese, Alexander Gombert

Journal Articles

Cytokine-mediated systemic inflammation after open thoracoabdominal aortic aneurysm (TAAA) repairs plays a pivotal role in disrupting circulatory homeostasis, potentially leading to organ dysfunction. The bioactive form of adrenomedullin (bio-ADM) is a peptide hormone with immunomodulatory and vasomotor effects, making it a potential diagnostic agent in these cases. This retrospective, bicentric study, conducted between January 2019 and December 2022, recruited 36 elective open TAAA repair patients in two German centres. Serum and plasma samples were collected at multiple time points to measure bio-ADM levels. The primary objective was to evaluate the association of bio-ADM levels with the onset of acute respiratory …

Medmicromaps, A Novel Decision-Tree Guide For Infectious Diseases Differential Diagnoses, And Evaluation Of Pre- And Post-Pandemic User Engagement By Preclinical Medical Students, Jason Ceballos, Tavsimran Luthra, Lucia Garces-Torres, Valerie Lentz, Jack Nelson, Claudia Carceles-Roman, Ian Holyoak, Jane Harrington

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

Background: Medical education has undergone major changes in the past 5 years to adapt to the digital-centered student population with diverse learning preferences. To address the challenges of shifting delivery modalities, multimedia resources were created to provide interactive e-learning material on infectious diseases for year 2 medical students.

Methods: Medical students at a USA-accredited Caribbean medical school were provided with supplemental e-learning materials including animations, illustrations, diagnostic algorithms aka MedMicroMaps, and Case-Based tutorials. Participants were classified by semester and lecture delivery: In-person: Cohort 1 (n=526); Virtual: Cohort 2 (n=651); and Hybrid: Cohort 3 ( …

A Thorough Examination Of Different Elisa Kits To Determine The Concentration Of S100b Linked To Intracranial Hemorrhage, Anthony Phan

University Honors Theses

Background: Traumatic Brain Injuries (TBI) and Intracranial Hemorrhages (ICH) are one of the leading causes of death. Faster diagnosis and treatment positively impact patient outcomes. Two protein markers (UCHL-1 and GFAP) were approved by the FDA as an indicator for prediction indicators of an ICH or moderate TBI.

Methods: In this project, the S100 Calcium Binding Protein B (S100B) was measured by performing an enzyme-linked immunoglobulin assay (ELISA) on the placebo arm of the Prehospital Tranexamic Acid Use for Traumatic Brain Injury" clinical trial. The aim of this project is to compare glial fibrillary acidic protein (GFAP) concentrations that were …

Colistin And Antimicrobial Resistance Among Gram-Negative Bacteria Isolated From Poultry In West Bank, Palestine, Mohammad Qadi, Rasha Khayyat, Safaa Alhato, Abdelraouf A. Elmanama, Ashraf R. Zayed, Muna M. Abbas, Maysa Daqqa, Faizeh Hussein, Ahmed Mousa

Palestinian Medical and Pharmaceutical Journal

Background: The escalating incidence of antimicrobial resistance in Gram-negative bacteria has elicited worldwide apprehension owing to its profound ramifications, such as the emergence of infections that cannot be effectively treated and may result in mortality. The poultry industry is of significant concern due to its substantial utilization of antimicrobials, including those regarded as last-resort therapies for complex multi-drug resistant Gram-negative infections. Methods: A comprehensive collection of ninety cloacal swabs was undertaken from a diverse range of thirty poultry farms located within the Nablus governorate during the period spanning from March to June in the year 2019. The swabs, specifically collected …

Flanker Task Performance In Young And Older Adults: A Behavioral And Erp Study, Fatima Medrano

Dissertations, Theses, and Capstone Projects

Research suggests that as we get older, executive function abilities decline (Hasher & Zacks, 1988; Salthouse, 1996). One affected ability is that of inhibitory control, which aids in monitoring our responses to non-target stimuli or information. Current research on inhibition reveals inconsistencies across studies. Monitoring brain responses during the Flanker (used to measure inhibitory control) task may add valuable insight into the processes underlying group differences behaviorally, by studying the N200 and P300 event-related potentials which have been associated with inhibitory control processes. This study investigated whether there are differences between older and younger adults in inhibitory control and whether …

Cognitive And Neuroscientific Perspectives Of Healthy Ageing, Jon B. Prince, Helen L. Davis, Jane Tan, Katrina Muller-Townsend, Shaun Markovic, David M. G. Lewis, Brianne Hastie, Matthew B. Thompson, Peter D. Drummond, Hakuei Fujiyama, Hamid R. Sohrabi

Research outputs 2022 to 2026

With dementia incidence projected to escalate significantly within the next 25 years, the United Nations declared 2021–2030 the Decade of Healthy Ageing, emphasising cognition as a crucial element. As a leading discipline in cognition and ageing research, psychology is well-equipped to offer insights for translational research, clinical practice, and policy-making. In this comprehensive review, we discuss the current state of knowledge on age-related changes in cognition and psychological health. We discuss cognitive changes during ageing, including (a) heterogeneity in the rate, trajectory, and characteristics of decline experienced by older adults, (b) the role of cognitive reserve in age-related cognitive decline, …