Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 5)bisphosphate (1)
- Acetylcholine (1)
- Acute Kidney Rejection (1)
- Affective analgesia (1)
- Animal model (1)
-
- Base excison repair (1)
- Behavior (1)
- Biological evaluation (1)
- CANDIDA AND PROSTAGLANDIN EFFECTS ON IMMUNE RESPONSES (1)
- Carbachol (1)
- Colon cancer (1)
- Contextual Analysis (1)
- Cornea (1)
- DNA polymerase beta (1)
- DVH (1)
- Defensin (1)
- Dopamine (1)
- Epilepsy (1)
- Evidence-Based Medicine (1)
- FBW7 (1)
- FUNGAL IMMUNOLOGY (1)
- FUNGAL MOLECULAR BIOLOGY (1)
- Folate deficiency (1)
- G protein-coupled receptors (1)
- Graduate Medical Education (1)
- HOST-PATHOGEN INTERACTION (1)
- Hippocalcin (1)
- IMMUNOMODULATORY ROLE OF PROSTAGLANDINS DURING CANDIDIASIS (1)
- INTERCATION OF CANDIDA WITH DENDRITIC CELLS IN PRESENCE OF PROSTAGLANDIN (1)
- Immunity (1)
Articles 1 - 11 of 11
Full-Text Articles in Entire DC Network
Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza
Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza
Wayne State University Dissertations
ACTIVATION OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION
by
MICHAEL FREZZA
August 2010
Advisor: Dr. Q. Ping Dou
Major: Cancer Biology
Degree: Doctor of Philosophy
The ubiquitin-proteasome pathway serves as a quality control mechanism to regulate the degradation of intracellular proteins involved in a wide array of cellular processes including tumorigeneis. Thus targeting key features of protein turnover responsible for the growth and proliferation of cancer have emerged as a favorable approach in cancer therapy. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of …
Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans, Gitanjali Kundu
Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans, Gitanjali Kundu
Wayne State University Dissertations
Candida albicans, an opportunistic fungal pathogen, poses a significant clinical threat to immunocompromised patients. Diseases associated with this fungus ranges from superficial mucosal infection to life-threatening systemic candidiasis. The mechanisms by which Candida persists at mucosal surfaces in the face of an adaptive response are unclear. Candida produces immunomodulatory oxylipins that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this fungus during host pathogen interactions, both in vitro with dendritic cells (DCs) and macrophages, and …
Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown
Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown
Wayne State University Dissertations
ABSTRACT
RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION
By
KRISTIAN L. BROWN
2010
Advisor: Gregory Auner, PhD
Major: Biomedical Engineering
Degree: Doctor of Philosophy
Despite the advances made in the area of kidney transplantation, the disparity between the demand and available donated organs remains a dominant and unresolved issue. Given the paucity of available renal allografts the preservation of existing grafts is vital. One factor that has negatively impacted renal allograft survival is acute rejection (AR). Traditionally, kidney transplant centers have used elevations in serum creatinine as a screening tool for detecting AR. However, …
Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning, Bo Zhao
Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning, Bo Zhao
Wayne State University Dissertations
Purpose: Both spatial and biological information are necessary in order to perform true optimization of a treatment plan and for predicting clinical outcome. The goal of this work is to develop an enhanced treatment plan evaluation tool which incorporates biological parameters and retains spatial dose information.
Methods: A software system named SABER (Spatial And Biological Evaluation for Radiotherapy) is developed which provides biological plan evaluation with a novel combination of features. It incorporates hyperradiosensitivity using the induced-repair model and applies the new concept of Dose Convolution Filter (DCF) to simulate dose wash-out …
Defensins In Ocular Immunity, Minhao Wu
Defensins In Ocular Immunity, Minhao Wu
Wayne State University Dissertations
Corneal infection with P. aeruginosa results in corneal perforation in susceptible
B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal
infection, and their potential synergy. Immunostaining and real-time RT-PCR data
demonstrated that their expression was either constitutive (mBD1 and mBD2) or
inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately
regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA
treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in
ocular defense. Moreover, in vivo studies demonstrated individual and combined effects
of mBD2 and …
Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation, Claudio Alberto Villalobos
Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation, Claudio Alberto Villalobos
Wayne State University Dissertations
One of the most characteristic features of pyramidal cells in the prefrontal cortex (PFC) is that they present a slow afterhyperpolarizing current (IsAHP) that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via GΑq/11 G proteins, thus it is thought that neurotransmitters regulate neuronal excitability through the inhibition of this current. IsAHP is known to be mediated by calcium-activated potassium channels, however, neither the identity of the channel underlying this current nor its mechanism of activation are yet well understood. Recent reports have questioned a direct role …
Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase Β Haploinsufficient Mice, Lisa F. Ventrella Lucente
Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase Β Haploinsufficient Mice, Lisa F. Ventrella Lucente
Wayne State University Dissertations
The data presented in this research is central to establishing the role that the base excision repair pathway (BER) plays in the development and progression of colon cancer when dietary folate is deficient. Both cellular folate restriction and BER deficiencies have been shown to result in the accumulation of endogenous damage and lesions that could eventually develop into carcinogenesis. In this study, a dietary folate deficiency (FD) resulted in a significant increase in aberrant crypt foci (ACF) formation and triggered liver tumorogenesis in wildtype (WT) animals, as did a BER deficiency in DNA polymerase Β haploinsufficient (Β-pol+/-) mice exposed to …
Development And Validation Of A Measurement Scale To Analyze The Environment For Evidence-Based Medicine Learning And Practice By Medical Residents, Fangqiong Mi
Wayne State University Dissertations
A growing number of residency programs are instituting curricula to include the component of evidence-based medicine (EBM) principles and process. However, these curricula may not be able to achieve the optimal learning outcomes, perhaps because various contextual factors are often overlooked when EBM training is being designed, developed, and implemented. The purpose of the study was to develop and validate an instrument, the EBM Environment Scale, to analyze the environment for EBM learning and practice as perceived by medical residents.
The development of the EBM Environment Scale underwent the process of content domain identification, item generation, review by content experts …
Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet
Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet
Wayne State University Dissertations
Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …
The Interictal State In Epilepsy And Behavior, Daniel Tice Barkmeier
The Interictal State In Epilepsy And Behavior, Daniel Tice Barkmeier
Wayne State University Dissertations
Epilepsy is one of the most common neurological diseases, affecting up to 1% of the world population. Epilepsy remains poorly understood and there are currently no medications to cure it. Patients with epilepsy have both seizures as well as another type of abnormal activity between seizures, known as interictal spikes. Interictal spikes have thus far been poorly researched, yet growing evidence supports an important role for them in epilepsy. In this project, we first show the high variability between reviewers in marking interictal spikes on intracranial EEG, and then develop and test an automated detection method to solve this problem. …
Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia, Amanda Larson Gedman
Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia, Amanda Larson Gedman
Wayne State University Dissertations
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric ALL cases and is associated with early relapse and inferior outcome. The poorer prognosis of T-ALL compared to B-precursor ALL may in part reflect the lack of unique features on which to base therapy. NOTCH1 mutations are of particular interest since these were reported in 37-71% of T-ALLs. The prognostic value of NOTCH1 mutations remains controversial as both favorable and unfavorable associations were reported, whereas in other studies, there were no associations between NOTCH1 mutations and treatment outcome. We explored the impact of mutations in NOTCH1, FBW7 and PTEN on …