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Molecular And Cellular Mechanisms Of Reelin Signaling In The Adult Hippocampus, Justin Howard Trotter
Molecular And Cellular Mechanisms Of Reelin Signaling In The Adult Hippocampus, Justin Howard Trotter
USF Tampa Graduate Theses and Dissertations
The Reelin signaling pathway is critical for neuronal migration during development and the function of excitatory synapses in the adult forebrain. Despite a growing body of evidence implicating impaired Reelin signaling in the pathogenesis of numerous neuropsychiatric and neurodegenerative disorders, including Schizophrenia and Alzheimer's disease, little is known still regarding the specific molecular and cellular mechanisms whereby Reelin signaling modulates the function of synapses to enable normal learning and memory. In this dissertation, we addressed these knowledge gaps by identifying mechanisms of Reelin proteolysis following synaptic potentiation (Chapter 2) and dissociated the synaptic function of Reelin signaling at excitatory (Chapter …