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Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown
Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown
Wayne State University Dissertations
ABSTRACT
RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION
By
KRISTIAN L. BROWN
2010
Advisor: Gregory Auner, PhD
Major: Biomedical Engineering
Degree: Doctor of Philosophy
Despite the advances made in the area of kidney transplantation, the disparity between the demand and available donated organs remains a dominant and unresolved issue. Given the paucity of available renal allografts the preservation of existing grafts is vital. One factor that has negatively impacted renal allograft survival is acute rejection (AR). Traditionally, kidney transplant centers have used elevations in serum creatinine as a screening tool for detecting AR. However, …
Defensins In Ocular Immunity, Minhao Wu
Defensins In Ocular Immunity, Minhao Wu
Wayne State University Dissertations
Corneal infection with P. aeruginosa results in corneal perforation in susceptible
B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal
infection, and their potential synergy. Immunostaining and real-time RT-PCR data
demonstrated that their expression was either constitutive (mBD1 and mBD2) or
inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately
regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA
treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in
ocular defense. Moreover, in vivo studies demonstrated individual and combined effects
of mBD2 and …