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Thromboresistance Characterization Of Extruded Nitric Oxide Releasing Silicone Catheters, Kagya Amoako, Christopher Archangeli, Hitesh Handa, Terry Major, Mark E. Meyerhoff, Gail M. Annich, Robert H. Bartlett May 2012

Thromboresistance Characterization Of Extruded Nitric Oxide Releasing Silicone Catheters, Kagya Amoako, Christopher Archangeli, Hitesh Handa, Terry Major, Mark E. Meyerhoff, Gail M. Annich, Robert H. Bartlett

Mechanical and Industrial Engineering Faculty Publications

Intravascular catheters used in clinical practice can activate platelets, leading to thrombus formation and stagnation of blood flow. Nitric oxide (NO)-releasing polymers have been shown previously to reduce clot formation on a number of blood contacting devices. In this work, trilaminar NO-releasing silicone catheters were fabricated and tested for their thrombogenicity. All catheters had specifications of L = 6 cm, inner diameter = 21 gauge (0.0723 cm), outer diameter = 12 gauge (0.2052 cm), and NO-releasing layer thickness = 200 ± 11 µm. Control and NO-releasing catheters were characterized in vitro for their NO flux and NO release duration by …


Analysis Of The Penney-Ante Game Using Difference Equations: Development Of An Optimal And A Mixed-Strategies Protocol, Carl Barratt, Pauline Schwartz Jan 2012

Analysis Of The Penney-Ante Game Using Difference Equations: Development Of An Optimal And A Mixed-Strategies Protocol, Carl Barratt, Pauline Schwartz

Chemistry and Chemical Engineering Faculty Publications

Penney-Ante is a well known two-player (Player I and Player II) game based on an information paradox. We present a new approach, using difference-equations, to analyzing the outcome for each player. One strategy yields a winning outcome of 75% for Player II, the player playing second. The approach also permits investigation of non-optimal strategies, and demonstrates how mixing of such strategies can be used to tune the winning edge of either player. We generalize the analysis to accommodate the possibility of a biased coin.


Kinetic Models Of The Prebiotic Replication Of Dsrna Under Thermal Cycling Conditions, Pauline Schwartz, Dante M. Lepore, Carl Barratt Jan 2012

Kinetic Models Of The Prebiotic Replication Of Dsrna Under Thermal Cycling Conditions, Pauline Schwartz, Dante M. Lepore, Carl Barratt

Chemistry and Chemical Engineering Faculty Publications

We present computational models for the replication of double stranded RNA (dsRNA) or related macromolecules under thermal cycling conditions that would reflect prebiotic (i.e. non-enzymatic) environments. Two models of the replication of dsRNA are represented as multi-step chemical systems. The objective of this investigation was to better understand the kinetic features of such chemical systems. It is shown that thermal cycling in a chemical system is advantageous (relative to a fixed temperature) if there are two competing reactions, one favored at high temperature and one favored at low temperature. For the prebiotic replication of dsRNA, a high temperature favors formation …


Network-Based Data Collection For A Project-Based Freshman Class, Samuel Bogan Daniels, Cheryl Q. Li, David Harding Jan 2012

Network-Based Data Collection For A Project-Based Freshman Class, Samuel Bogan Daniels, Cheryl Q. Li, David Harding

Mechanical and Industrial Engineering Faculty Publications

The hands-on experience for engineering students is often lacking with class sizes increasing and classroom resources under constant pressure. Even with smaller class sizes and studio classrooms there is only so much equipment and technical support to run experiments and allow for student interaction. Network-based data collection and control may alleviate some of these issues and allow for more hands-on experiences, although remote, in the classroom. This paper discusses the interesting problems and not so obvious pitfalls of setting up some simple network-based data acquisition systems for a multidisciplinary freshman level engineering course. The course as currently taught includes some …