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Turbulent Mixers For Protein Folding Experiments, Venkatesh Inguva Nov 2018

Turbulent Mixers For Protein Folding Experiments, Venkatesh Inguva

Doctoral Dissertations

Protein folding studies require the development of micro-mixers that require less sample, mix at faster rates, and still provide a high signal to noise ratio. Chaotic to marginally turbulent micro-mixers are promising candidates for this application. In this study, various turbulence and unsteadiness generation concepts are explored that avoid cavitation. The mixing enhancements include flow turning regions, flow splitters, and vortex shedding. The relative effectiveness of these different approaches for rapid micro-mixing is discussed. Simulations found that flow turning regions provided the best mixing profile. Various turbulence models are simulated to determine appropriate model of the design requirements. Experimental validation …


Model-Based Predictive Analytics For Additive And Smart Manufacturing, Zhuo Yang Oct 2018

Model-Based Predictive Analytics For Additive And Smart Manufacturing, Zhuo Yang

Doctoral Dissertations

Qualification and certification for additive and smart manufacturing systems can be uncertain and very costly. Using available historical data can mitigate some costs of producing and testing sample parts. However, use of such data lacks the flexibility to represent specific new problems which decreases predictive accuracy and efficiency. To address these compelling needs, in this dissertation modeling techniques are introduced that can proactively estimate results expected from additive and smart manufacturing processes swiftly and with practical levels of accuracy and reliability. More specifically, this research addresses the current challenges and limitations posed by use of available data and the high …


Computational Exploration Of Flash-Boiling Internal Flow And Near-Nozzle Spray, Sampath K. Rachakonda Oct 2018

Computational Exploration Of Flash-Boiling Internal Flow And Near-Nozzle Spray, Sampath K. Rachakonda

Doctoral Dissertations

Gasoline engines operating under the principle of direct injection are susceptible to flash-boiling due to superheated nature of the fuel and the sub-atmospheric in-cylinder pressures during injection. A review of the literature on flash-boiling sprays shows that a majority of the studies have focused on the far-field regions of the spray, with limited attention given to understanding the influences of the injector geometry and the near-nozzle regions of the spray. Modeling the internal nozzle flow and the primary atomization, on which the far-field spray depends, is a challenge. This thesis, therefore, is aimed at understanding the complex flow through a …


Performance And Economic Analysis Of Hybrid Microhydro Systems, Ram Poudel Oct 2018

Performance And Economic Analysis Of Hybrid Microhydro Systems, Ram Poudel

Doctoral Dissertations

Microhydro (MHP) systems usually employ unregulated turbines and an electronic load controller, a demand-side control device. Existing analytical models for such systems are lacking details, especially supply-side flow control, for performance simulation at hourly or sub-hourly scales. This work developed stochastic models for downscaling of streamflow and an empirical model of MHP systems. We integrated these models within the framework of Hybrid2 tool to simulate the long-term performance of a tri-hybrid system consisting of hydropower, solar PV and wind turbine. Based on an additive model of time series decomposition, we develop a Multiple Input Single Output (MISO) model in order …


Modeling Deformation Behavior And Strength Characteristics Of Sand-Silt Mixtures: A Micromechanical Approach, Mehrashk Meidani Mar 2018

Modeling Deformation Behavior And Strength Characteristics Of Sand-Silt Mixtures: A Micromechanical Approach, Mehrashk Meidani

Doctoral Dissertations

This dissertation is comprised of six chapters. In the first chapter the motivation of this research, which was modeling the deformation behavior and strength characteristics of soils under internal erosion, is briefly explained. In the second chapter a micromechanis-based stress-strain model developed for prediction of sand-silt mixtures behavior is presented. The components of the micromechanics-based model are described and undrained behavior of six different types of sand-silt mixtures is predicted for several samples with different fines contents. The need for a more comprehensive compression model for sand-silt mixtures is identified at the end of this chapter. This desired compression model …


Aeroelastic Simulation Of Wind Turbines Using Free Vortex Methods And Strategies For Accelerating The Computation, Shujian Liu Mar 2018

Aeroelastic Simulation Of Wind Turbines Using Free Vortex Methods And Strategies For Accelerating The Computation, Shujian Liu

Doctoral Dissertations

This dissertation integrated the free vortex method code Wake Induced Dynamics Simulator (WInDS), which was developed by Sebastian et al., into the open source and widely-used software FAST. A range of computational strategies including paral- lelization and Treecode algorithms are used to increase the computational efficiency of the software. Full aero-hydro-servo-elastic simulations with free vortex method are conducted, which focus on an in-depth study on the influence of the aeroelasticity of the wind turbine and platform motions on the unsteadiness of the aerodynamics, and the comparison of aeroelastic responses of two floating wind turbine concepts. This dissertation also applies long …


Supporting Engineering Design Of Additively Manufactured Medical Devices With Knowledge Management Through Ontologies, Thomas Hagedorn Mar 2018

Supporting Engineering Design Of Additively Manufactured Medical Devices With Knowledge Management Through Ontologies, Thomas Hagedorn

Doctoral Dissertations

Medical environments pose a substantial challenge for engineering designers. They combine significant knowledge demands with large investment for new product development and severe consequences in the case of design failure. Engineering designers must contend with an often-chaotic environment to which they have limited access and familiarity, a user base that is difficult to engage and highly diverse in many attributes, and a market structure that often pits stakeholders against one another. As medical care in general moves towards personalized models and surgical tools towards less invasive options emerging manufacturing technologies in additive manufacturing offer significant potential for the design of …