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Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
A Microfluidic Paper-Based Electrochemical Biosensor Array For Multiplexed Detection Of Metabolic Biomarkers, Chen Zhao, Martin M. Thuo, Xinyu Liu
A Microfluidic Paper-Based Electrochemical Biosensor Array For Multiplexed Detection Of Metabolic Biomarkers, Chen Zhao, Martin M. Thuo, Xinyu Liu
Martin M. Thuo
Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to …
Aerodynamic Simulation Of Vertical-Axis Wind Turbines, A. Korobenko, Ming-Chen Hsu, I. Akkerman, Y. Bazilevs
Aerodynamic Simulation Of Vertical-Axis Wind Turbines, A. Korobenko, Ming-Chen Hsu, I. Akkerman, Y. Bazilevs
Ming-Chen Hsu
Full-scale, 3D, time-dependent aerodynamics modeling and simulation of a Darrieus-type vertical-axis wind turbine (VAWT) is presented. The simulations are performed using a moving-domain finite-element-based ALE-VMS technique augmented with a sliding-interface formulation to handle the rotor-stator interactions present. We simulate a single VAWT using a sequence of meshes with increased resolution to assess the computational requirements for this class of problems. The computational results are in good agreement with experimental data. We also perform a computation of two side-by-side counterrotating VAWTs to illustrate how the ALE-VMS technique may be used for the simulation of multiple turbines placed in arrays.
Finite Element Simulation Of Wind Turbine Aerodynamics: Validation Study Using Nrel Phase Vi Experiment, Ming-Chen Hsu, Ido Akkerman, Yuri Bazilevs
Finite Element Simulation Of Wind Turbine Aerodynamics: Validation Study Using Nrel Phase Vi Experiment, Ming-Chen Hsu, Ido Akkerman, Yuri Bazilevs
Ming-Chen Hsu
A validation study using the National Renewable Energy Laboratory (NREL) Phase VI wind turbine is presented. The aerodynamics simulations are performed using the finite element arbitrary Lagrangian–Eulerian–variational multiscale formulation augmented with weakly enforced essential boundary conditions. In all cases, the rotor is assumed to be rigid and its rotation is prescribed. The rotor-only simulations are performed for a wide range of wind conditions, and the computational results compare favorably with the experimental findings in all cases. The sliding-interface method is adopted for the simulation of the full wind turbine configuration. The full-wind-turbine simulations capture the blade–tower interaction effect, and the …
Blended Isogeometric Shells, D. J. Benson, S. Hartmann, Y. Bazilevs, Ming-Chen Hsu, T.J.R. Hughes
Blended Isogeometric Shells, D. J. Benson, S. Hartmann, Y. Bazilevs, Ming-Chen Hsu, T.J.R. Hughes
Ming-Chen Hsu
We propose a new isogeometric shell formulation that blends Kirchhoff–Love theory with Reissner–Mindlin theory. This enables us to reduce the size of equation systems by eliminating rotational degrees of freedom while simultaneously providing a general and effective treatment of kinematic constraints engendered by shell intersections, folds, boundary conditions, the merging of NURBS patches, etc. We illustrate the blended theory’s performance on a series of test problems.
Biophotonic Logic Devices Based On Quantum Dots And Temporally-Staggered Forster Energy Transfer Relays, Jonathan C. Claussen, W. Russ Algar, Niko Hildebrandt, Kimihiro Susumu, Mario G. Ancona, Igor L. Medintz
Biophotonic Logic Devices Based On Quantum Dots And Temporally-Staggered Forster Energy Transfer Relays, Jonathan C. Claussen, W. Russ Algar, Niko Hildebrandt, Kimihiro Susumu, Mario G. Ancona, Igor L. Medintz
Jonathan C. Claussen
Integrating photonic inputs/outputs into unimolecular logic devices can provide significantly increased functional complexity and the ability to expand the repertoire of available operations. Here, we build upon a system previously utilized for biosensing to assemble and prototype several increasingly sophisticated biophotonic logic devices that function based upon multistep Förster resonance energy transfer (FRET) relays. The core system combines a central semiconductor quantum dot (QD) nanoplatform with a long-lifetime Tb complex FRET donor and a near-IR organic fluorophore acceptor; the latter acts as two unique inputs for the QD-based device. The Tb complex allows for a form of temporal memory by …
Emerging Technologies For Non-Invasive Quantification Of Physiological Oxygen Transport In Plants, P. Chaturvedi, M. Taguchi, S. L. Burrs, B. A. Hauser, W.W. A.W. Salim, Jonathan C. Claussen, E. S. Mclamore
Emerging Technologies For Non-Invasive Quantification Of Physiological Oxygen Transport In Plants, P. Chaturvedi, M. Taguchi, S. L. Burrs, B. A. Hauser, W.W. A.W. Salim, Jonathan C. Claussen, E. S. Mclamore
Jonathan C. Claussen
Oxygen plays a critical role in plant metabolism, stress response/signaling, and adaptation to environmental changes (Lambers and Colmer, Plant Soil 274:7-15, 2005; Pitzschke et al., Antioxid Redox Signal 8:1757-1764, 2006; Van Breusegem et al., Plant Sci 161:405-414, 2001). Reactive oxygen species (ROS), by-products of various metabolic pathways in which oxygen is a key molecule, are produced during adaptation responses to environmental stress. While much is known about plant adaptation to stress (e.g., detoxifying enzymes, antioxidant production), the link between ROS metabolism, O2 transport, and stress response mechanisms is unknown. Thus, non-invasive technologies for measuring O2 are critical for understanding the …