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The Effects Of Aging On Cardiac Mechanics, Samuel C. Lieber
The Effects Of Aging On Cardiac Mechanics, Samuel C. Lieber
Dissertations
It is well established that the aging heart exhibits left ventricular (LV) diastolic dysfunction and changes in mechanical properties, which have been attributed to alterations in the extracellular matrix (ECM). The investigators tested the hypothesis that the mechanical properties of cardiac myocytes significantly change with aging thereby contributing to the LV diastolic dysfunction. Cellular mechanical properties were determined by indenting cells with an atomic force microscope (AFM). The indentation results were interpreted by modeling the AFM probe as a blunted cone and determining an apparent elastic modulus (B) with classical infinitesimal strain theory (CIST). A commercially available finite element software …
Elastic Modulus Of Amorphous Sio2 Nanowires, Hai Ni, Xiaodong Li, Hongsheng Gao
Elastic Modulus Of Amorphous Sio2 Nanowires, Hai Ni, Xiaodong Li, Hongsheng Gao
Faculty Publications
Amorphous SiO2 nanowires with diameter ranging from 50 to 100 nm were synthesized using chemical vapor deposition(CVD) under an argon atmosphere at atmospheric pressure. Nanoscale three-point bending tests were performed directly on individual amorphous SiO2 nanowires using an atomic force microscope (AFM).Elastic modulus of the amorphous SiO2 nanowires was measured to be 76.6±7.2GPa, which is close to the reported value of the bulk SiO2 and thermally grown SiO2 thin films, but lower than that of plasma-enhanced CVD SiO2 thin films. The amorphous SiO2 nanowires exhibit brittle fracture failure in bending.