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Modeling Of Transport In Anatomic Respiratory Airways: Applications In Targeted Drug Delivery And Airborne Pathogenic Transmissions, Mohammad Mehedi Hasan Akash

Electronic Theses and Dissertations

This thesis aims to explore the potential of improving the efficacy of drugs for treatment of viral infections by targeting the nasopharynx, which is commonly the first site of infection for many viral pathogens. Currently, intranasal sprays are used, but the standard protocol (“Current Use” or CU) results in suboptimal drug deposition at the nasopharynx. To address this issue, an “Improved Use” or, IU protocol has been proposed, which involves pointing the spray bottle at a shallower angle and aiming slightly towards the cheeks. The IU delivery is also robust to perturbations in spray direction, which highlights the practical utility …

On The Simulation Of Supersonic Flame Holder Cavities With Openfoam, Zachary Chapman

Electronic Theses and Dissertations

One of the next major advancements in the aerospace industry will be hypersonic flight. However, to achieve hypersonic flight, propulsion systems capable of reaching hypersonic speeds need to be developed. One of the more promising hypersonic propulsion systems is the scramjet engine, however, several problems still need to be explored before reliable scramjet engines can be produced, the biggest being keeping the engine ignited. This has led to the use of flame holder cavities to create a region of subsonic flow within the engine to allow combustion to occur. High experimental costs make the use of computational fluid dynamic (CFD) …

Predictive Model Of Air Dam Deflection Under Aerodynamic Loads, Chang Kyun Kang

Electronic Theses and Dissertations

Plastic components are widely used on the exterior body of automotive vehicles. When the vehicle is moving, these components experience deformation caused by air flow. Simultaneously, the deformation affects the flow of air around the vehicle. This research is focused on developing virtual simulation techniques for determining the vehicle air dam behaviour under aerodynamic loads. The main objective of this research is to develop a fluid-structure interaction (FSI) methodology for predicting deflection of the air dam.

Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) codes are coupled so that fluid pressure and air dam displacement parameters are exchanged. The …

Assessing The Effectiveness Of Cfd To Solve An Inverse Problem Of Thermal Profiles For The Protodune-Sp Neutrino Detector, Cecilia Anne Streff

Electronic Theses and Dissertations

Computational fluid dynamics (CFD) is a branch of fluid mechanics which is employed to numerically solve complex fluid, heat transfer, and multiphysics problems. Traditionally, CFD techniques are used to solve “forward” problems—using some known information of a system as inputs to a representative model to predict experimental measurements or expected system behavior. The work presented here demonstrates how CFD may be used to solve an “inverse” problem—given limited experimental data and some model, predict (previously unidentified) “input” system (or system model) parameters. The case study for this research uses a validated CFD modeling approach of the liquid argon (LAr) region …

Using Computational Fluid Dynamics To Accurately Model Agricultural Spray Nozzles, Zachary Chapman

Electronic Theses and Dissertations

Computational fluid dynamics (CFD) is a tool used by engineers in many industries to study fluid flow. A relatively new industry to adopt the use of CFD is the agricultural industry. The present work seeks to understand whether CFD can be used to accurately model spray nozzles. A spray nozzle commonly used in agricultural spraying was simulated. First, the impact of factors such as mesh size, mesh type, and physics models have on the solution were investigated. Next, a method to pulse the spray was determined. This was required to compare simulation results with experimental data. A user-defined function was …

Quantifying The Performance Of The Protodune Single Phase Neutrino Detector Using Computational Fluid Dynamics, Dillon Pedersen

Electronic Theses and Dissertations

The goal of this research is to provide scientifically-valid computationally generated data of the flow, thermal, and impurity data of the ProtoDUNE single phase detector. Results are compared and validated against an actual detector that is currently being utilized to collect temperature and impurity data. This research will investigate the flows inside these detection chambers using computational fluid dynamics to find approximate solutions to the governing equations of fluid mechanics. Impurity and flow data will allow researchers to determine if results collected are being obstructed by high levels of impurity. Novel approaches have been developed to strike a balance between …

Computational Fluid Dynamics Modeling Of The Effects Of Water Injection In A Diesel Engine, Rabun Z. Wallace

Electronic Theses and Dissertations

Water injection has been used in internal combustion engines for many years. It has been used to cool combustion temperatures, reduce emissions, and in some instances clean carbon buildup from the cylinder. Research has shown that the water to fuel mass ratio is most effective between 20-30%, so the upper and lower limit were used for simulations in Converge CFD. To validate the CFD model, a case without water injection was compared to experimental data from Sandia National Laboratory. The predicted in-cylinder pressure and heat release rate showed good agreement with the experimental data. Cases were run with the injection …

Feature-Based Neuro-Symbolic Networks For Global Diagnostics, Tracy Lynn Schantz

Electronic Theses and Dissertations

Engineered system diagnostics have been researched over the years with many successful results. From transportation systems to office technologies, many have been equipped with self-diagnostic capabilities and are called Smart Machines. In spite of these advances, current diagnostic systems are driven by direct sensory information without much concern for patterns of the system behavior or features associated with them. For large-scale systems with complex dynamics, global as well as local diagnostics become of great importance, where sensory information is used as input for the local diagnostics, and patterns of behavior or features are utilized for global diagnostics.

The main objective …

Meshless Hemodynamics Modeling And Evolutionary Shape Optimization Of Bypass Grafts Anastomoses, Zaher El Zahab

Electronic Theses and Dissertations

Objectives: The main objective of the current dissertation is to establish a formal shape optimization procedure for a given bypass grafts end-to-side distal anastomosis (ETSDA). The motivation behind this dissertation is that most of the previous ETSDA shape optimization research activities cited in the literature relied on direct optimization approaches that do not guaranty accurate optimization results. Three different ETSDA models are considered herein: The conventional, the Miller cuff, and the hood models. Materials and Methods: The ETSDA shape optimization is driven by three computational objects: a localized collocation meshless method (LCMM) solver, an automated geometry pre-processor, and a genetic-algorithm-based …