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Thromboresistance Characterization Of Extruded Nitric Oxide Releasing Silicone Catheters, Kagya Amoako, Christopher Archangeli, Hitesh Handa, Terry Major, Mark E. Meyerhoff, Gail M. Annich, Robert H. Bartlett
Thromboresistance Characterization Of Extruded Nitric Oxide Releasing Silicone Catheters, Kagya Amoako, Christopher Archangeli, Hitesh Handa, Terry Major, Mark E. Meyerhoff, Gail M. Annich, Robert H. Bartlett
Mechanical and Industrial Engineering Faculty Publications
Intravascular catheters used in clinical practice can activate platelets, leading to thrombus formation and stagnation of blood flow. Nitric oxide (NO)-releasing polymers have been shown previously to reduce clot formation on a number of blood contacting devices. In this work, trilaminar NO-releasing silicone catheters were fabricated and tested for their thrombogenicity. All catheters had specifications of L = 6 cm, inner diameter = 21 gauge (0.0723 cm), outer diameter = 12 gauge (0.2052 cm), and NO-releasing layer thickness = 200 ± 11 µm. Control and NO-releasing catheters were characterized in vitro for their NO flux and NO release duration by …