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Modeling And Simulation Of Particle-Particle Interaction In A Magnetophoretic Bio-Separation Chip, Manjurul Alam, Matin Golozar, Jeff Darabi

SIUE Faculty Research, Scholarship, and Creative Activity

A Lagrangian particle trajectory model is developed to predict the interaction between cell-bead particle complexes and to track their trajectories in a magnetophoretic bio-separation chip. Magnetic flux gradients are simulated in OpenFOAM CFD software and imported into MATLAB to obtain the trapping lengths and trajectories of the particles. A connector vector is introduced to calculate the interaction force between cell-bead complexes as they flow through a microfluidic device. The interaction force calculations are performed for cases where the connector vector is parallel, perpendicular, and at an angle of 45 degrees with the applied magnetic field. The trajectories of the particles …