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Modeling And Simulation Of Particle-Particle Interaction In A Magnetophoretic Bio-Separation Chip, Manjurul Alam, Matin Golozar, Jeff Darabi
Modeling And Simulation Of Particle-Particle Interaction In A Magnetophoretic Bio-Separation Chip, Manjurul Alam, Matin Golozar, Jeff Darabi
SIUE Faculty Research, Scholarship, and Creative Activity
A Lagrangian particle trajectory model is developed to predict the interaction between cell-bead particle complexes and to track their trajectories in a magnetophoretic bio-separation chip. Magnetic flux gradients are simulated in OpenFOAM CFD software and imported into MATLAB to obtain the trapping lengths and trajectories of the particles. A connector vector is introduced to calculate the interaction force between cell-bead complexes as they flow through a microfluidic device. The interaction force calculations are performed for cases where the connector vector is parallel, perpendicular, and at an angle of 45 degrees with the applied magnetic field. The trajectories of the particles …
Experimental And Computational Study Of Gas Bubble Removal In A Microfluidic System Using Nanofibrous Membranes, Hamed Gholami Derami, Ravindra Vundavilli, Jeff Darabi
Experimental And Computational Study Of Gas Bubble Removal In A Microfluidic System Using Nanofibrous Membranes, Hamed Gholami Derami, Ravindra Vundavilli, Jeff Darabi
SIUE Faculty Research, Scholarship, and Creative Activity
This paper presents a simple and efficient method for removing gas bubbles from a microfluidic system. This bubble removal system uses a T-junction configuration to generate gas bubbles within a water-filled microchannel. The generated bubbles are then transported to a bubble removal region and vented through a hydrophobic nanofibrous membrane. Four different hydrophobic Polytetrafluorethylene (PTFE) membranes with different pore sizes ranging from 0.45 to 3 μm are tested to study the effect of membrane structure on the system performance. The fluidic channel width is 500 μm and channel height ranges from 100 to 300 μm. Additionally, a 3D computational fluid …