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A Critical Proton Mr Spectroscopy Marker Of Alzheimer Early Neurodegenerative Change: Low Hippocampal Naa/Cr Ratio Impacts Apoe 4 Mexico City Children And Their Parents., Partha S. Mukherjee
A Critical Proton Mr Spectroscopy Marker Of Alzheimer Early Neurodegenerative Change: Low Hippocampal Naa/Cr Ratio Impacts Apoe 4 Mexico City Children And Their Parents., Partha S. Mukherjee
Mathematics Faculty Publications and Presentations
Severe air pollution exposures produce systemic, respiratory, myocardial, and brain inflammation and Alzheimer’s disease (AD) hallmarks in clinically healthy children. We tested whether hippocampal metabolite ratios are associated with contrasting levels of air pollution, APOE and BMI in paired healthy children and one parent sharing the same APOE alleles. We used (1) H-MRS to interrogate bilateral hippocampal single-voxel in 57 children (12.45± 3.4 years) and their 48 parents (37.5± 6.78 years) low pollution city v Mexico City (MC). NAA/Cr, Cho/Cr, and mI/Cr metabolite ratios were analysed. The right hippocampus N-acetylaspartate/creatine (NAA/Cr) was significantly different between cohorts (p=0.007). The NAA/Cr ratio …