Digital Commons Network^™

Theory, Computation, And Modeling Of Cancerous Systems, Sameed Ahmed

Theses and Dissertations

This dissertation focuses on three projects. In Chapter 1, we derive and implement the compact implicit integration factor method for numerically solving partial differential equations. In Chapters 2 and 3, we generalize and analyze a mathematical model for the nonlinear growth kinetics of breast cancer stem cells. And in Chapter 4, we develop a novel mathematical model for the HER2 signaling pathway to understand and predict breast cancer treatment. Due to the high order spatial derivatives and stiff reactions, severe temporal stability constraints on the time step are generally required when developing numerical methods for solving high order partial differential …

Algorithmic Factorization Of Polynomials Over Number Fields, Christian Schulz

Mathematical Sciences Technical Reports (MSTR)

The problem of exact polynomial factorization, in other words expressing a polynomial as a product of irreducible polynomials over some field, has applications in algebraic number theory. Although some algorithms for factorization over algebraic number fields are known, few are taught such general algorithms, as their use is mainly as part of the code of various computer algebra systems. This thesis provides a summary of one such algorithm, which the author has also fully implemented at https://github.com/Whirligig231/number-field-factorization, along with an analysis of the runtime of this algorithm. Let k be the product of the degrees of the adjoined elements used …

An Operational View In Computational Construction Of Information, Florentin Smarandache, Stefan Vladutescu, Constantin Dima, Valeriu Voinea

Branch Mathematics and Statistics Faculty and Staff Publications

The paper aims to explain the technology of emergence of information. Our research proves that information as communicational product is the result of processing within some operations, actions, mechanisms and strategies of informational material meanings. Are determined eight computational-communicative operations of building information. Information occurs in two communication phases, syncretic and the segregation-synthetic. The syncretic phase consists of four operations: referral of significant field, primary delimitation of information, detection-looking information and an anticipative-draft constitution (feedforward). The segregation-synthetic phase also includes four operations: discrimination, identification, interpretation and confrontation (feedback). In the future we will investigate informational actions, mechanisms and strategies.

A New Undergraduate Curriculum On Mathematical Biology At University Of Dayton, Muhammad Usman, Amit Singh

Amit Singh

The beginning of modern science is marked by efforts of pioneers to understand the natural world using a quantitative approach. As Galileo wrote, "the book of nature is written in the language of mathematics". The traditional undergraduate course curriculum is heavily focused on individual disciplines like biology, physics, chemistry, mathematics rather than interdisciplinary courses. This fragmented teaching of sciences in majority of universities leave biology outside the quantitative and mathematical approaches. The landscape of biomedical science has transformed dramatically with advances in high throughput experimental approaches, which led to the huge amount of data. The best possible approach to generate …

Two Compact Incremental Prime Sieves, Jonathan P. Sorenson

Scholarship and Professional Work - LAS

A prime sieve is an algorithm that finds the primes up to a bound n. We say that a prime sieve is incremental, if it can quickly determine if n+1 is prime after having found all primes up to n. We say a sieve is compact if it uses roughly √n space or less. In this paper, we present two new results.

• We describe the rolling sieve, a practical, incremental prime sieve that takes O(n log log n) time and O(√n log n) bits of space.

• We also …

Elliptic Curves Of High Rank, Cecylia Bocovich

Mathematics, Statistics, and Computer Science Honors Projects

The study of elliptic curves grows out of the study of elliptic functions which dates back to work done by mathematicians such as Weierstrass, Abel, and Jacobi. Elliptic curves continue to play a prominent role in mathematics today. An elliptic curve E is defined by the equation, y^₂ = x³ + ax + b, where a and b are coefficients that satisfy the property 4a³ + 27b² = 0. The rational solutions of this curve form a group. This group, denoted E(Q), is known as the Mordell-Weil group and was proved by Mordell to be isomorphic …

Incorporating Quantitative Reasoning In Common Core Courses: Mathematics For The Ghost Map, John R. Jungck

Numeracy

How can mathematics be integrated into multi-section interdisciplinary courses to enhance thematic understandings and shared common readings? As an example, four forms of quantitative reasoning are used to understand and critique one such common reading: Steven Berlin Johnson’s "The Ghost Map: The Story of London's Most Terrifying Epidemic - and How it Changed Science, Cities and the Modern World" (Riverhead Books, 2006). Geometry, statistics, modeling, and networks are featured in this essay as the means of depicting, understanding, elaborating, and critiquing the public health issues raised in Johnson’s book. Specific pedagogical examples and resources are included to illustrate applications and …

A New Undergraduate Curriculum On Mathematical Biology At University Of Dayton, Muhammad Usman, Amit Singh

Mathematics Faculty Publications

The beginning of modern science is marked by efforts of pioneers to understand the natural world using a quantitative approach. As Galileo wrote, "the book of nature is written in the language of mathematics". The traditional undergraduate course curriculum is heavily focused on individual disciplines like biology, physics, chemistry, mathematics rather than interdisciplinary courses. This fragmented teaching of sciences in majority of universities leave biology outside the quantitative and mathematical approaches. The landscape of biomedical science has transformed dramatically with advances in high throughput experimental approaches, which led to the huge amount of data. The best possible approach to generate …

False Positives And Referral Bias: Content For A Quantitative Literacy Course, Stuart Boersma, Teri Willard

Numeracy

An extended study of accuracy in medical screening is presented as a useful application to increase students’ quantitative reasoning skills. Two detailed examples are presented. The first explores the frequency of obtaining false positive results from a medical screening tool while the second examines the issue of referral bias and its effect on the apparent sensitivity and specificity of the screening tool. Results from student assessments indicate that the activity increases one’s ability to define terms such as “false positive” and “false negative” and increases one’s ability to read and compute with information obtained from a two-way table. Teacher assessment …

Evaluating The Computational Efficiency Of Xfbat And Fbat For Family Based Studies, Yanwei Ouyang

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Family-based study designs are often employed when investigating the genetic causes of complex disease. While the transmission disequilibrium test (TDT) and its extensions were developed to use family data for assessing linkage between a known genetic marker and a disease-causing gene, the so-called FBAT approach proposed by Rabinowitz and Laird (2000) effectively subsumes these family-based procedures as special cases. FBAT is fully conditional, but its implementation in the freely available FBAT software package uses a large-sample distributional approximation to compute p-values. The exact distribution for FBAT can be enumerated, but doing so explicitly is computationally intensive, particularly for relatively larger …

Totally Real Galois Representations In Characteristic 2 And Arithmetic Cohomology, Heather Aurora Florence De Melo

Theses and Dissertations

The purpose of this paper is to provide new examples supporting a conjecture of Ash, Doud, and Pollack. This conjecture involves Galois representations taking Gal(Q bar/Q) to the general linear group of 3 x 3 matrices in characterisic 2, and our examples are where complex conjugation is mapped to the identity. Since this case has not yet been examined, the results of this paper are quite significant.

Explicit Computations Supporting A Generalization Of Serre's Conjecture, Brian Francis Hansen

Theses and Dissertations

Serre's conjecture on the modularity of Galois representations makes a connection between two-dimensional Galois representations and modular forms. A conjecture by Ash, Doud, and Pollack generalizes Serre's to higher-dimensional Galois representations. In this paper we discuss an explicit computational example supporting the generalized claim. An ambiguity in a calculation within the example is resolved using a method of complex approximation.

Undergraduates, The Right Questions, And Cayley Produce Results, Gary J. Sherman

Mathematical Sciences Technical Reports (MSTR)

During the summers of 1989, 1990, and 1991, eighteen undergraduates participated in a National Science Foundation Research Experiences for Undergraduates program at Rose-Hulman for which the author was the principal investigator. This paper provides some examples of the mathematics discovered during these three summers and discusses the philosophy, environment and process which made these discoveries possible.