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Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar
KGI Theses and Dissertations
The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …
Lattice Of Maximal-Primary Ideals In Quadratic Orders, Ryan Bridges
Lattice Of Maximal-Primary Ideals In Quadratic Orders, Ryan Bridges
Mathematics & Statistics ETDs
An order is a subring of the ring of integers of an algebraic extension, Peruginelli and Zanardo classified the lattices of orders with prime index inside te ring of integers of quadratic extensions of the rational numbers. The lattices are quite striking and have different layered structure depending on whether the prime is inert, split, or ramified. This thesis considers the orders which have prime power index inside the Gaussian integers. This is a nice generalization of the work of Peruginelli and Zanardo, and succeeds in a few classifications of specific instances of orders derived from inert primes.
A Study Of The Design Of Adaptive Camber Winglets, Justin J. Rosescu
A Study Of The Design Of Adaptive Camber Winglets, Justin J. Rosescu
Master's Theses
A numerical study was conducted to determine the effect of changing the camber of a winglet on the efficiency of a wing in two distinct flight conditions. Camber was altered via a simple plain flap deflection in the winglet, which produced a constant camber change over the winglet span. Hinge points were located at 20%, 50% and 80% of the chord and the trailing edge was deflected between -5° and +5°. Analysis was performed using a combination of three-dimensional vortex lattice method and two-dimensional panel method to obtain aerodynamic forces for the entire wing, based on different winglet camber configurations. …
Groups Of Divisibility, Seth J. Gerberding
Groups Of Divisibility, Seth J. Gerberding
Honors Thesis
In this thesis, we examine a part of abstract algebra known as Groups of Divisibility. We construct these special groups from basic concepts. We begin with partially-ordered sets, then build our way into groups, rings, and even structures akin to rings of polynomials. In particular, we explore how elementary algebra evolves when an ordering is included with the operations. Our results follow the work done by Anderson and Feil, however we include more explicit proofs and constructions. Our primary results include proving that a group of divisibility can be provided with an order to make it a partially-ordered group; that …