Digital Commons Network^™

Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar

KGI Theses and Dissertations

The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …

Pascal's Mystic Hexagon In Tropical Geometry, Hanna Hoffman

HMC Senior Theses

Pascal's mystic hexagon is a theorem from projective geometry. Given six points in the projective plane, we can construct three points by extending opposite sides of the hexagon. These three points are collinear if and only if the six original points lie on a nondegenerate conic. We attempt to prove this theorem in the tropical plane.

Spectral Analysis Of Complex Dynamical Systems, Casey Lynn Johnson

CGU Theses & Dissertations

The spectrum of any differential equation or a system of differential equations is related to several important properties about the problem and its subsequent solution. So much information is held within the spectrum of a problem that there is an entire field devoted to it; spectral analysis. In this thesis, we perform spectral analysis on two separate complex dynamical systems. The vibrations along a continuous string or a string with beads on it are the governed by the continuous or discrete wave equation. We derive a small-vibrations model for multi-connected continuous strings that lie in a plane. We show that …

Use Of Kalman Filtering In State And Parameter Estimation Of Diabetes Models, Cassidy Le

HMC Senior Theses

Diabetes continues to affect many lives every year, putting those affected by it at higher risk of serious health issues. Despite many efforts, there currently is no cure for diabetes. Nevertheless, researchers continue to study diabetes in hopes of understanding the disease and how it affects people, creating mathematical models to simulate the onset and progression of diabetes. Recent research by David J. Albers, Matthew E. Levine, Andrew Stuart, Lena Mamykina, Bruce Gluckman, and George Hripcsak¹ has suggested that these models can be furthered through the use of Data Assimilation, a regression method that synchronizes a model with a …

On The Mysteries Of Interpolation Jack Polynomials, Havi Ellers

HMC Senior Theses

Interpolation Jack polynomials are certain symmetric polynomials in N variables with coefficients that are rational functions in another parameter k, indexed by partitions of length at most N. Introduced first in 1996 by F. Knop and S. Sahi, and later studied extensively by Sahi, Knop-Sahi, and Okounkov-Olshanski, they have interesting connections to the representation theory of Lie algebras. Given an interpolation Jack polynomial we would like to differentiate it with respect to the variable k and write the result as a linear combination of other interpolation Jack polynomials where the coefficients are again rational functions in k. In this …

A Discrete Analogue For The Poincaré-Hopf Theorem, Savana Ammons

HMC Senior Theses

In this thesis, we develop a discrete analogue to the Poincaré–Hopf Theorem. We define the notion of a vector field on a graph, and establish an index theory for such a field. Specifically, we create well-defined indices for the nodes and “cells" formed by a planar graph. Then, we show that the sum of these indices remains constant for certain types of planar graphs, regardless of the discrete vector fields they have.

Where The Wild Knots Are, Forest Kobayashi

HMC Senior Theses

The new work in this document can be broken down into two main parts. In the first, we introduce a formalism for viewing the signed Gauss code for virtual knots in terms of an action of the symmetric group on a countable set. This is achieved by creating a "standard unknot" whose diagram contains countably-many crossings, and then representing tame knots in terms of the action of permutations with finite support. We present some preliminary computational results regarding the group operation given by this encoding, but do not explore it in detail. To make the encoding above formal, we require …

An Exploration Of Combinatorial Interpretations For Fibonomial Coefficients, Richard Shapley

HMC Senior Theses

We can define Fibonomial coefficients as an analogue to binomial coefficients as F(n,k) = F_nF_n-1 … F­_n-k+1 / F­_kF_k-­1…F₁, where F_n represents the nth Fibonacci number. Like binomial coefficients, there are many identities for Fibonomial coefficients that have been proven algebraically. However, most of these identities have eluded combinatorial proofs.

Sagan and Savage (2010) first presented a combinatorial interpretation for these Fibonomial coefficients. More recently, Bennett et al. (2018) provided yet another interpretation, that is perhaps more tractable. However, there still has been little progress towards using these interpretations …

A Coherent Proof Of Mac Lane's Coherence Theorem, Luke Trujillo

HMC Senior Theses

Mac Lane’s Coherence Theorem is a subtle, foundational characterization of monoidal categories, a categorical concept which is now an important and popular tool in areas of pure mathematics and theoretical physics. Mac Lane’s original proof, while extremely clever, is written somewhat confusingly. Many years later, there still does not exist a fully complete and clearly written version of Mac Lane’s proof anywhere, which is unfortunate as Mac Lane’s proof provides very deep insight into the nature of monoidal categories. In this thesis, we provide brief introductions to category theory and monoidal categories, and we offer a precise, clear development of …

Preliminary Study Of Highway Pavement And Materials, Omer Eljairi

CGU Theses & Dissertations

This preliminary study covered (a) the effects of in-place air voids and other factors on fatigue cracking using Long-Term Pavement Performance data, (b) fracture properties of asphalt concrete in a semicircular bend (SCB) test using a noncontact camera and crosshead movement, and (c) hot applied modified-binder-chip-seal field performance in California. The objective is to improve pavement performance and life, establish a quality assurance/quality control (QA/QC) tests of fracture properties of asphalt mixtures, and save millions of dollars on maintenance and rehabilitation. Chapter 1 investigated the effect of in-place air voids (AV), asphalt content (AC), bulk-specific gravity (BSG), and maximum specific …

Stationary Distribution Of Recombination On 4x4 Grid Graph As It Relates To Gerrymandering, Camryn Hollarsmith

Scripps Senior Theses

A gerrymandered political districting plan is used to benefit a group seeking to elect more of their own officials into office. This practice happens at the city, county and state level. A gerrymandered plan can be strategically designed based on partisanship, race, and other factors. Gerrymandering poses a contradiction to the idea of “one person, one vote” ruled by the United States Supreme Court case Reynolds v. Sims (1964) because it values one demographic’s votes more than another’s, thus creating an unfair advantage and compromising American democracy. To prevent the practice of gerrymandering, we must know how to detect a …

Discrete Geometry And Covering Problems, Alexander Hsu

CMC Senior Theses

This thesis explores several problems in discrete geometry, focusing on covering problems. We first go over some well known results, explaining Keith Ball's solution to the symmetric Tarski plank problem, as well as results of Alon and F\"uredi on covering all but vertices of a cube with hyperplanes. The former extensively utilizes techniques from matrix analysis, and the latter applies polynomial method. We state and explore the related problem, asking for the number of parallel hyperplanes required to cover a given discrete set of points in $\mathbb{Z}^{d}$ whose entries are bounded, and prove that there exist sets which are ``difficult'' …

Optimal Execution In Cryptocurrency Markets, Ethan Kurz

CMC Senior Theses

The purpose of this paper is to study the Almgren and Chriss model on the optimal execution of large block orders both on the NYSE and in cryptocurrency exchanges. Their model minimizes execution costs, which include linear temporary and permanent price impacts. We focus on how the stock market microstructure differs from a cryptocurrency exchange microstructure and what that means for how the model functions. Once the model and microstructures are explained, we examine how the Almgren-Chriss model functions with stocks from the NYSE, looking at specifically selling a large number of shares. We then investigate how a large "wholesale" …

Detection And Localization Of Linear Features Based On Image Processing Methods, Sean Cormick Matz

CGU Theses & Dissertations

In this work, the general problem of the detection of features in images is considered. One of the methods, the orientation detection of lines, utilized the Radon transform (sinogram) of an image to detect lines at different angles in an image. The line thickness algorithm was generated by finding a pattern formed by particular lines in an image. The filtering of reconstructed images dealt with the removal of blur and other artifacts that arose in the course of inverting the Radon transform of an image to attempt to obtain the original image.