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Cell Velocity Is Asymptotically Independent Of Force: A Differential Equation Model With Random Switching., J. C. Dallon, Emily J. Evans, Christopher P. Grant, William V. Smith
Cell Velocity Is Asymptotically Independent Of Force: A Differential Equation Model With Random Switching., J. C. Dallon, Emily J. Evans, Christopher P. Grant, William V. Smith
Faculty Publications
Numerical simulations suggest that average velocity of a biological cell depends largely on attachment dynamics and less on the forces exerted by the cell. We determine the relationship between two models of cell motion, one based on finite spring constants modeling attachment properties (a randomly switched differential equation) and a limiting case (a centroid model-a generalized random walk) where spring constants are infinite. We prove the main result of this paper, the Expected Velocity Relationship theorem. This result shows that the expected value of the difference between cell locations in the differential equation model at the initial time and at …
Deciphering The Transport Of Elastic Filaments By Antagonistic Motor Proteins, Stephanie Portet, Cecil Leduc, Sandrine Etienne-Manneville, J. C. Dallon
Deciphering The Transport Of Elastic Filaments By Antagonistic Motor Proteins, Stephanie Portet, Cecil Leduc, Sandrine Etienne-Manneville, J. C. Dallon
Faculty Publications
Intermediate filaments are long elastic fibres that are transported by microtubule-associated motor proteins kinesin and dynein inside the cell. How elastic filaments are efficiently transported by antagonistic motors is not well understood and difficult to measure with current experimental techniques. Adapting the tug-of-war paradigm for vesicle-like cargos, we develop a mathematical model to describe the motion of an elastic filament punctually bound to antagonistic motors. As observed in cells, up to 3 modes of transport are obtained; dynein-driven retrograde, kinesin-driven anterograde fast motions and a slow motion. Motor properties and initial conditions that depend on intracellular context, regulate the transport …
Stochastic Modeling Reveals How Motor Protein And Filament Properties Affect Intermediate Filament Transport, J. C. Dallon, Cecil Leduc, Sandrine Etienne-Manneville, Stephanie Portet
Stochastic Modeling Reveals How Motor Protein And Filament Properties Affect Intermediate Filament Transport, J. C. Dallon, Cecil Leduc, Sandrine Etienne-Manneville, Stephanie Portet
Faculty Publications
Intermediate filaments are a key component of the cytoskeleton. Their trans- port along microtubules plays an essential role in the control of the shape and structural organization of cells. To identify the key parameters responsible for the control of intermediate filament transport, we generated a model of elastic filament transport by microtubule-associated dynein and kinesin. The model is also applicable to the transport of any elastically-coupled cargoes. We inves- tigate the effect of filament properties such as number of motor binding sites, length, and elasticity on motion of filaments. Additionally, we consider the ef- fect of motor properties, i.e. off …