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Self-Assembled Two-Component Organic Tubes: Structures And Applications, Wenlang Liang
Self-Assembled Two-Component Organic Tubes: Structures And Applications, Wenlang Liang
Electronic Theses and Dissertations
Bile acids are physiologically important metabolites, which are synthesized in liver as the end products of cholesterol metabolism and then secreted into the intestines. They play a critical role in the digestion and absorption of fats and fat-soluble vitamins through emulsifications. The amphipathic and chiral nature of bile acids makes their unique building blocks for assembling supramolecular structures including vesicles, fibers, ribbons and hollow tubes. Lithocholic acid (LCA) is a secondary bile acid. Our studies show LCA can selfassemble into helical tubes in aqueous solution by the linear aggregation and fusion of vesicles. The objective of this dissertation is to …
Branched And Spiral Organic Nanotubes Based On The Self-Assembly Of Bile Acids, Xuejun Zhang
Branched And Spiral Organic Nanotubes Based On The Self-Assembly Of Bile Acids, Xuejun Zhang
Electronic Theses and Dissertations
The self-assembly of chiral amphiphilic molecules in aqueous solutions is of particular interest because the chirality of individual molecules is often expressed in their supermolecular structures. Self-assembled tubes made of chiral amphiphilic molecules represent useful supramolecular architectures which hold promise as controlled release vehicles for drug delivery, encapsulates for functional molecules, and nanoreactors for chemical reactions. Lithocholic acid (LCA) is a secondary bile acid with the concentration being identical to that of cholesterol in the hepatic bile and gallbladder. It has a rigid, nearly planar hydrophobic steroid nucleus, with four hydrogen atoms and one hydroxyl group directed toward the concave …