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Formation And Characterization Of Polymerized Supported Phospholipid Bilayers And The In Vitro Interactions Of Macrophages And Fibroblasts., Jonathan Michael Page
Formation And Characterization Of Polymerized Supported Phospholipid Bilayers And The In Vitro Interactions Of Macrophages And Fibroblasts., Jonathan Michael Page
Masters Theses
Planar supported, polymerized phospholipid bilayers (PPBs) composed of 1,2-bis[10-(2’,4’-hexadienoyloxy)decanoyl]-sn-glycero-3-phosphocholine (bis-SorbPC or BSPC) were generated by a redox polymerization method. The PPBs were supported by a silicon substrate. The PPBs were characterized and tested for uniformity and stability under physiological conditions. The PPBs were analyzed in vitro with murine derived cells that are pertinent to the host response. Cellular attachment and phenotypic changes in RAW 264.7 macrophages and NIH 3T3 fibroblasts were investigated on PPBs and compared to bare silicon controls. Fluorescent and SEM images were used to observe cellular attachment and changes in cellular behavior. The PPBs showed much lower …