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Role Of The Immune System In The Modulation Of The Mmr-Deficient Intestinal Stem Cell Niche, Shepard Conner Dec 2023

Role Of The Immune System In The Modulation Of The Mmr-Deficient Intestinal Stem Cell Niche, Shepard Conner

Dissertations & Theses (Open Access)

Mismatch Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including MLH1, MSH2, MSH6, and PMS2. These genes play a critical role in repairing errors that occur in base pairing by stabilizing the genetic material. When the MMR system fails to correct those errors, MMR deficiency occurs where monoallelic mutations in the MMR genes result in a condition known as Lynch Syndrome (LS). LS makes up approximately 3% of all colorectal cancer (CRC) and is regarded as a hereditary form of CRC, which progresses from MMR-deficient …


Remembering Paul Johnsgard, Linda R, Brown, Josef Kren Mar 2023

Remembering Paul Johnsgard, Linda R, Brown, Josef Kren

Zea E-Books Collection

Paul A. Johnsgard (1931–2021) was a friend of many, an artist, prolific author, teacher, and humble admirer of all living creatures. It was impossible to find someone at Nebraska Audubon Society or Nebraska Ornithologists’ Union meetings who did not know Paul Johnsgard. His more than 100 published books made him known not just in a community of ornithologists, birdwatchers, and bird lovers in the United States but also abroad. He was a world-renowned ornithologist and naturalist who remained deeply embedded in his local culture and its prairie environment.

We invited about 75 people to write a short memory of Paul. …


Richard Evans Schultes, James P. Smith Jr Jan 2022

Richard Evans Schultes, James P. Smith Jr

Botanical Studies

No abstract provided.


In Loving Memory Paul Austin Johnsgard: Memorial Service, Paul Johnsgard Jun 2021

In Loving Memory Paul Austin Johnsgard: Memorial Service, Paul Johnsgard

Paul Johnsgard Collection

3:00 p.rn. Sunday, June 20, 2021 Unitarian Church of Lincoln, 6300 A Street Lincoln, Nebraska. Officiating, Rev. Dr. Oscar Sinclair; Musician, Karine Gil

ORDER OF SERVICE Gathering Music Ringing of the Bell Welcome, Chalice Lighting, Responsorial Reading

Biography

Music - Morning has Broken by Cat Stevens

Personal Reflections - Part 1 Music - Sounds of the Platte River

Personal Reflections - Part 2

Summation - On Honor and Respect

Music - Blue Boat Home by Peter Mayer

Closing Words

Postlude - Migrations

In lieu of flowers, memorials should be directed to Spring Creek Prairie Audubon Center, P. O. Box 117, …


Ua37/44 Faculty Personal Papers Gordon Wilson, Wku Archives Jan 2020

Ua37/44 Faculty Personal Papers Gordon Wilson, Wku Archives

WKU Archives Collection Inventories

Personal papers of Gordon Wilson.


A Prairie And Its People: Conflict And Cooperation. E. Frank Schramm, Joseph E.A. Alexis, The Amos Eager Family, The University Of Nebraska And Other Notable Owners Of Nine Mile Prairie And Its Environs, Jon H. Oberg Jan 2019

A Prairie And Its People: Conflict And Cooperation. E. Frank Schramm, Joseph E.A. Alexis, The Amos Eager Family, The University Of Nebraska And Other Notable Owners Of Nine Mile Prairie And Its Environs, Jon H. Oberg

Publications of UNSM Staff and Affiliates

This study looks at the social history of individuals connected to a particular geographic quadrant -- Section 1 of Middle Creek precinct, Lancaster County, Nebraska. This an area famous for its natural history, as it is the home of Nine Mile Prairie. But the property owners in this section have a colorful history that encompasses the fields of sports, politics, academics, foreign wars, and crime. The study looks primarily at E. Frank Schramm, Joseph E.A. Alexis, and the Amos Eager family, who with other owners contributed importantly to the history and development of the City of Lincoln and the State …


Inventory Of California Land Pamphlets In Hornbeck Collection Apr 2018

Inventory Of California Land Pamphlets In Hornbeck Collection

California Land Pamphlet Inventory

A document with active links that lists the content of the California Land Pamphlets found in nine volumes, plus three additional publications.


Rhoa Gtpase Controls Yap-Mediated Ereg Signaling In Small Intestinal Stem Cell Maintenance, Ming Liu, Zheng Zhang, Leesa Sampson, Xuan Zhou, Kodandaramireddy Nalapareddy, Benjamin Feng, Shailaja Akunuru, Jaime Melendez, Ashley Kuenzi Davis, Feng Bi, Hartmut Geiger, Mei Xin, Yi Zheng Nov 2017

Rhoa Gtpase Controls Yap-Mediated Ereg Signaling In Small Intestinal Stem Cell Maintenance, Ming Liu, Zheng Zhang, Leesa Sampson, Xuan Zhou, Kodandaramireddy Nalapareddy, Benjamin Feng, Shailaja Akunuru, Jaime Melendez, Ashley Kuenzi Davis, Feng Bi, Hartmut Geiger, Mei Xin, Yi Zheng

Peer Reviewed Articles

RHOA, a founding member of the Rho GTPase family, is critical for actomyosin dynamics, polarity, and morphogenesis in response to developmental cues, mechanical stress, and inflammation. In murine small intestinal epithelium, inducible RHOA deletion causes a loss of epithelial polarity, with disrupted villi and crypt organization. In the intestinal crypts, RHOA deficiency results in reduced cell proliferation, increased apoptosis, and a loss of intestinal stem cells (ISCs) that mimic effects of radiation damage. Mechanistically, RHOA loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (S112A) mutant …


From Planning To Passing: The Amherst, Massachusetts Plastic Bag Ban, Kevin J. Hollerbach Jan 2017

From Planning To Passing: The Amherst, Massachusetts Plastic Bag Ban, Kevin J. Hollerbach

Student Showcase

This case study will detail the background and influences for a plastic bag ban in the town of Amherst, outline the steps taken from planning to passage, and address roadblocks and missteps that may be avoided with the implementation of future bans. It is my hope that this document will not only serve as a guide, but also an inspiration for additional local action in Massachusetts and across the country. No matter what the national political climate or attitude towards environmental issues, local action is always possible, and change is usually easier than you think. Think globally, act locally!


Alan J. Stone, Alan J. Stone, Institute Of Child Nutrition Oct 2016

Alan J. Stone, Alan J. Stone, Institute Of Child Nutrition

Oral History Project (all interviews)

Alan J. Stone’s internships included co-chair of the Law Students Civil Rights Research Council, and what became the National Welfare Rights Organization, after going to law school at George Washington University in Washington, DC. He worked as one of the organizers of the Poor People’s March on Washington. After law school Stone went to work as the junior counsel on Senator George McGovern’s U.S. Senate Select Committee on Nutrition and Human Needs. He went on the work on legislation that made School Breakfast, WIC, and Summer Food Service and Child Care Food Program all permanent programs in America. Stone later …


A Quantitative Analysis Of Hugelkultur And Its Potential Application On Karst Rocky Desertified Areas In China, Megan Laffoon Aug 2016

A Quantitative Analysis Of Hugelkultur And Its Potential Application On Karst Rocky Desertified Areas In China, Megan Laffoon

Mahurin Honors College Capstone Experience/Thesis Projects

A type of environmental degradation, karst rocky desertification (KRD) refers to areas where the soil loss exposes the bedrock and reduces the land’s ability to sustain life and is particularly widespread through the vast karst area of rural southwest China. Hugelkultur is a permaculture method that harnesses the wood decomposition process by burying logs beneath soil. We proposed that hugel beds will demonstrate a higher water holding capacity and enhance soil development, in a way that may show promise as a potential method to help alleviate problems of KRD. Soil samples were taken from hugel plots, non-hugel plots, and KRD-like …


Community Seed Banks: Origins, Evolution, And Prospects, Charles A. Francis Oct 2015

Community Seed Banks: Origins, Evolution, And Prospects, Charles A. Francis

Department of Agronomy and Horticulture: Faculty Publications

As a survey of contemporary community-level seed banks, this is an excellent compilation and instructive guide. The first section provides an overview of how seed banks originated, their varied goals and activities, several contrasting forms of management, and how they organize and perform to meet these goals. An intriguing claim in the book is that the concept of “seed banks is only some three decades old,” while in fact the practice of saving, preserving, and exchanging seed within a community is probably as old as human communities themselves.

Organized seed banks often serve specific functions: preserving seeds, providing seed access …


The Lli Chronicle Volume 4 Number 2, Nova Southeastern University Apr 2013

The Lli Chronicle Volume 4 Number 2, Nova Southeastern University

Lifelong Learning Institute Newsletters

No abstract provided.


Diet Composition And Insulin Action In Animal Models, Leonard H. Storlien, J Higgins, T C. Thomas, Marc A. Brown, Hong-Qin Wang, Xu-Feng Huang, Paul Else Sep 2012

Diet Composition And Insulin Action In Animal Models, Leonard H. Storlien, J Higgins, T C. Thomas, Marc A. Brown, Hong-Qin Wang, Xu-Feng Huang, Paul Else

Xu-Feng Huang

No abstract provided.


Aging, Stem Cells And The Cancer Stem Cell Hypothesis, Dave Comstock Jan 2012

Aging, Stem Cells And The Cancer Stem Cell Hypothesis, Dave Comstock

Dissertations and Theses

No abstract provided.


Altruism And The Administration Of The Universe: Kirtley Fletcher Mather On Science And Values, Edward B. Davis Jan 2011

Altruism And The Administration Of The Universe: Kirtley Fletcher Mather On Science And Values, Edward B. Davis

Biology Educator Scholarship

Few American scientists have devoted as much attention to religion and science as Harvard geologist Kirtley Fletcher Mather (1888-1978). Responding to antievolutionism during the 1920s, he taught Sunday School classes, assisted in defending John Scopes, and wrote Science in Search of God (1928). Over the next 40 years, Mather explored the place of humanity in the universe and the presence of values in light of what he often called "the administration of the universe," a term and concept he borrowed from his former teacher, geologist Thomas Chrowder Chamberlin. Human values, including cooperation and altruism, had emerged in such a context: …


Funding Stem Cell Research: The Convergence Of Science, Religion & Politics In The Formation Of Public Health Policy, Edward A. Fallone Jan 2011

Funding Stem Cell Research: The Convergence Of Science, Religion & Politics In The Formation Of Public Health Policy, Edward A. Fallone

Edward A Fallone

The controversy over the funding of stem cell research by the federal government is used as a case study for examining how policy choices are made in the field of public bioethics. This article examines the manner in which the decision to fund stem cell research has been influenced by the convergence of evolving scientific knowledge, conflicting religious values, and the role of elected officials in a representative democracy. The article begins by reviewing the current state of scientific knowledge concerning adult stem cells, embryonic stem cells, induced pluripotent stem cells, and the process of direct cell re-programming. Because each …


Toward A Working- Waterfront Ethic: Preserving Access To Maine’S Coastal Economy, Heritage, And Local Seafood, Robert Snyder Jan 2011

Toward A Working- Waterfront Ethic: Preserving Access To Maine’S Coastal Economy, Heritage, And Local Seafood, Robert Snyder

Maine Policy Review

Maine has one of the most beautiful coastlines in the world, one for which people are willing to pay a premium. But for Maine fisherman, the coast is how they access their liveli­hood. In 2002 only 25 miles of Maine’s 5,300-mile coastline supported working-waterfront access. This article discusses creative and innovative strategies to preserve Maine’s working waterfront, including current-use taxation, purchase of development rights, and community-supported fisheries (CSF).


Complete 2010 Program Apr 2010

Complete 2010 Program

John Wesley Powell Student Research Conference

No abstract provided.


The Southern Family Farm As Endangered Species: Possibilities For Survival In Barbara Kingsolver's Prodigal Summer, Suzanne W. Jones Jan 2006

The Southern Family Farm As Endangered Species: Possibilities For Survival In Barbara Kingsolver's Prodigal Summer, Suzanne W. Jones

English Faculty Publications

At the same time some southern studies scholars are positioning the U.S. South in a larger cultural, historic, and economic region that encompasses the Caribbean and Latin America, some southern environmentalist writers, such as long-time essayist and novelist Wendell Berry and activist-turned-memoirist Janisse Ray, are finding a pressing need to focus on smaller bioregions and the locatedness of the human subject. These writers believe that agribusiness and consumer ignorance are driving small farmers out of business and that clear-cutting timber and farming practices dependent on chemicals are threatening local ecosystems. Best-selling novelist Barbara Kingsolver has joined their ranks. With her …


American Society Of Parasitologists Newsletter, V. 27, No. 3, Autumn 2005, Scott Lyell Gardner Oct 2005

American Society Of Parasitologists Newsletter, V. 27, No. 3, Autumn 2005, Scott Lyell Gardner

American Society of Parasitologists: Newsletter

An issue of the American Society of Parasitologists' quarterly newsletter, also called the Journal of Parasitology Newsletter.


Thinking Critically About Science And Religion: Disclosure Interviews Massimo Pigliucci, Jeff West, Viva Nordberg Apr 2005

Thinking Critically About Science And Religion: Disclosure Interviews Massimo Pigliucci, Jeff West, Viva Nordberg

disClosure: A Journal of Social Theory

No abstract provided.


The Nebline, October 2003 Oct 2003

The Nebline, October 2003

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Contents:

Check Your Home for Biological Pollutants
Growing Hardy Bulbs
Garden Guide
Time for Garden Cleanup
Storing Vegetables
Horticulture Information Center
Hints for Fruit Storage
Get Started on Your Winter Bird Feeding Program
Hedge Apples: Not a Good Insect Repellent
What are Zoonoses?
Last Household Hazardous Waste Collection!
Don’t Become a Farm Accident Statistic
Add Lime Now for Next Spring’s Alfalfa
Fatality Rate Higher for Senior Farmers
Protect Hearing on the Farm
Preparing an Emergency Water Supply
Site Evaluation
Maintaining Rubber Tires on Farm Equipment
ATVenture Workshop at Halsey 4-H Camp
Ak-Sar-Ben Youth Expo Winners
Charter Club Applications Due Oct. …


Duane Isely (1918-2000): A Tribute, Stanley L. Welsh, Deborah Q. Lewis Jan 2001

Duane Isely (1918-2000): A Tribute, Stanley L. Welsh, Deborah Q. Lewis

Journal of the Iowa Academy of Science: JIAS

Duane Isely, Distinguished Professor Emeritus, Department of Botany, Iowa State University, Ames, Iowa, died on 6 December 2000. Dr. Isely was an outstanding plant taxonomist with expertise in other fields as well, especially in seed technology and weed identification and control. He was born in Bentonville, Arkansas, on 24 October 1918 into a family of academicians. His father, Dwight Isely, was professor and later Dean of Agriculture at the University of Arkansas, and his mother, Blessie Elise Dort Isely, also taught at the University of Arkansas and eventually received her Ph.D.


Reflections On Scientific And Religious Metaphor, Ursula Goodenough Jun 2000

Reflections On Scientific And Religious Metaphor, Ursula Goodenough

Biology Faculty Publications & Presentations

The importance of scientific conflicts for theology and philosophy is difficult to judge. In many disputes of significance, prominent scientists can be found on both sides. Profound philosophical and religious implications are sometimes said to be implied by the new theory as well. This article examines the dispute over natural selection between Richard Dawkins and Stephen Jay Gould as a contemporary instance of such a conflict. While both claim that profound philosophical conclusions flow from their own alternative account of evolution, I suggest that the implication is not as great as is claimed and that the alleged implications have as …


Diet Composition And Insulin Action In Animal Models, Leonard H. Storlien, J Higgins, T C. Thomas, Marc A. Brown, Hong-Qin Wang, Xu-Feng Huang, Paul Else Jan 2000

Diet Composition And Insulin Action In Animal Models, Leonard H. Storlien, J Higgins, T C. Thomas, Marc A. Brown, Hong-Qin Wang, Xu-Feng Huang, Paul Else

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.


Diffuse Neuroendocrine System: Structural And Functional Effects Of Radiation Injury To Amine Precursor Uptake And Decarboxylation (Apud) Cells, I. M. Kvetnoy, V. V. Yuzhakov, A. O. Molotkov, L. N. Bandurko, R. A. Brodsky, N. D. Yakovleva Jan 1996

Diffuse Neuroendocrine System: Structural And Functional Effects Of Radiation Injury To Amine Precursor Uptake And Decarboxylation (Apud) Cells, I. M. Kvetnoy, V. V. Yuzhakov, A. O. Molotkov, L. N. Bandurko, R. A. Brodsky, N. D. Yakovleva

Scanning Microscopy

The paper presents a review of the results obtained by the authors on the study of external (gamma) and internal (I-131) radiation effects on the functional morphology and linkage of the diffuse neuroendocrine system (DNES) and amine precursor uptake and decarboxylation (APUD) cells of the stomach and duodenum. The investigations performed enabled us to determine that the morphological changes noted in APUD cells had a dose and time dependency. The present study supports the point of view that the radiation initiates serotonin release from APUD cells, which appears to initiate the mechanism of early postirradiation dysfunctions of the gastrointestinal tract …


Ec93-447 Documents For Decision Making: Living Wills And Medical Durable Powers Of Attorney, Georgia L. Stevens Jan 1993

Ec93-447 Documents For Decision Making: Living Wills And Medical Durable Powers Of Attorney, Georgia L. Stevens

University of Nebraska-Lincoln Extension: Historical Materials

Every person has a unique belief system including personal values based on family traditions, life experience, spiritual and religious beliefs, and knowledge. Medical decisions that we make for ourselves are based on those beliefs and values that matter most to us. Most of us are aware of the court battles that have raged over "right to die" cases.

This publication helps a person understand the meaning of the living will and medical durable powers of attorney.


An Economic And Sociologic Analysis Of The Marketing Sector Of The Tennessee Craft Industry, University Of Tennessee Agricultural Experiment Station, John R. Brooker, Merv J. Yetley Jun 1978

An Economic And Sociologic Analysis Of The Marketing Sector Of The Tennessee Craft Industry, University Of Tennessee Agricultural Experiment Station, John R. Brooker, Merv J. Yetley

Bulletins

No abstract provided.


The Non-Teratogenic Effects In Mice Progeny By Maternal Treatment With Amygdalin, Victoria Ann Rowe Jan 1978

The Non-Teratogenic Effects In Mice Progeny By Maternal Treatment With Amygdalin, Victoria Ann Rowe

Master's Theses

No abstract provided.