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Serum Proteins Enhance Dispersion Stability And Influence The Cytotoxicity And Dosimetry Of Zno Nanoparticles In Suspension And Adherent Cancer Cell Models, Catherine B. Anders, Jordan J. Chess, Denise G. Wingett, Alex Punnoose
Serum Proteins Enhance Dispersion Stability And Influence The Cytotoxicity And Dosimetry Of Zno Nanoparticles In Suspension And Adherent Cancer Cell Models, Catherine B. Anders, Jordan J. Chess, Denise G. Wingett, Alex Punnoose
Biomolecular Research Center Publications and Presentations
Agglomeration and sedimentation of nanoparticles (NPs) within biological solutions is a major limitation in their use in many downstream applications. It has been proposed that serum proteins associate with the NP surface to form a protein corona that limits agglomeration and sedimentation. Here, we investigate the effect of fetal bovine serum (FBS) proteins on the dispersion stability, dosimetry, and NP-induced cytotoxicity of cationic zinc oxide nanoparticles (nZnO) synthesized via forced hydrolysis with a core size of 10 nm. Two different in vitro cell culture models, suspension and adherent, were evaluated by comparing a phosphate buffered saline (PBS) nZnO dispersion (nZnO/PBS) …
Improving The Selective Cancer Killing Ability Of Zno Nanoparticles Using Fe Doping, Aaron Thurber, Denise Wingett, John Rasmussen, Janet Layne, Lydia Johnson, Dmitri Tenne, Jianhui Zhang, Charles Hanna, Alex Punnoose
Improving The Selective Cancer Killing Ability Of Zno Nanoparticles Using Fe Doping, Aaron Thurber, Denise Wingett, John Rasmussen, Janet Layne, Lydia Johnson, Dmitri Tenne, Jianhui Zhang, Charles Hanna, Alex Punnoose
Lydia Johnson
This work reports a new method to improve our recent demonstration of zinc oxide (ZnO) nanoparticles (NPs) selectively killing certain human cancer cells, achieved by incorporating Fe ions into the NPs. Thoroughly characterized cationic ZnO NPs (∼6 nm) doped with Fe ions (Zn(1-x )Fe (x) O, x = 0-0.15) were used in this work, applied at a concentration of 24 μg/ml. Cytotoxicity studies using flow cytometry on Jurkat leukemic cancer cells show cell viability drops from about 43% for undoped ZnO NPs to 15% for ZnO NPs doped with 7.5% Fe. However, the trend reverses and cell viability increases with …
07. Criminal Justice, Northeastern State University
07. Criminal Justice, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
04. Botany, Northeastern State University
04. Botany, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
06. Computer Science, Northeastern State University
06. Computer Science, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
03. Biology, Northeastern State University
03. Biology, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
08. Engineering, Northeastern State University
08. Engineering, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
10. Forensic Science, Northeastern State University
10. Forensic Science, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
11. Genetics, Northeastern State University
11. Genetics, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
14. Optometry, Northeastern State University
14. Optometry, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
16. Physics, Northeastern State University
16. Physics, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
17. Psychology, Northeastern State University
17. Psychology, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
13. Mathematics, Northeastern State University
13. Mathematics, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
18. Statistics, Northeastern State University
18. Statistics, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
02. Animal Science, Northeastern State University
02. Animal Science, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
05. Chemistry, Northeastern State University
05. Chemistry, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
09. Environmental Science, Northeastern State University
09. Environmental Science, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
12. Kinesiology, Northeastern State University
12. Kinesiology, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
15. Pharmacy, Northeastern State University
15. Pharmacy, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.
19. Zoology, Northeastern State University
19. Zoology, Northeastern State University
Oklahoma Research Day Abstracts
No abstract provided.