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The Hippocampus And Adult Neurogenesis: A Neural Circuit With A Common Role In Behavioral Flexibility And Detailed Memory, Brian Pochinski

Theses and Dissertations

Work with patient H.M. sparked great interest in the role of the hippocampus in learning and memory. Later, the findings that new neurons are born in the adult dentate gyrus (DG) and that they become functionally integrated in neural circuits created new excitement in the field of learning and memory. While there is ample evidence that the hippocampus and adult neurogenesis are involved in learning and memory, similar inconsistencies in both areas have clouded interpretations of their precise role. We propose that studying the role of hippocampus and neurogenesis in the DG must be merged into a more cohesive field …

The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel

Doctoral Dissertations

Nocturnal sleep has been shown to benefit memory in adults and children. During the preschool age range (~3-5 years), the distribution of sleep across the 24-hour period changes dramatically. Children transition from biphasic sleep patterns (a nap in addition to overnight sleep) to a monophasic sleep pattern (only overnight sleep). In addition, early childhood is a time of neuronal plasticity and pronounced acquisition of new information. This dissertation sought to examine the relationship between daytime napping and memory consolidation in preschool-aged children during this transitional time. Children were taught either a declarative or an emotional task in the morning, and …

Experiencing The Ineffable, Joseph O'Brien

CrissCross

I can recall the first time I learned to take a fish off the hook after catching it. My grandfather and I were fishing in a river near my home in Connecticut, the sun shone off the yellow of a pumpkinseed sunfish's belly. After removing it from the hook, I put it in a five-gallon pail of water. Despite the clarity of the things I do recall, there are those elements of this memory that remain wholly inaccessible to me. I cannot remember whether it was late spring or early autumn, what color my rod was, or if there were …

Age-Related Changes In Sleep-Dependent Consolidation Of Visuo-Spatial Memory, Akshata Sonni

Masters Theses

Healthy aging is associated with a reduction in slow-wave sleep (SWS), crucial for declarative memory consolidation in young adults; consequently, previously observed benefits of sleep on declarative learning in older adults could reflect a passive role of sleep in protecting memories from waking interference, rather than an active, stabilizing effect. To dissociate the passive and active roles of sleep, a visuo-spatial task was administered; memory was probed after a 12 hr interval consisting of either daytime wake or overnight sleep and post-wake/post-sleep stability of the memories was tested following task-related interference. Ninety five older adults (mean=65.43 yrs; SD=7.6 yrs) and …

Dissociation Between Face Perception And Face Memory In Adults, But Not Children, With Developmental Prosopagnosia, Kirsten A. Dalrymple, Lúcia Garrido, Brad Duchaine

Dartmouth Scholarship

Cognitive models propose that face recognition is accomplished through a series of discrete stages, including perceptual representation of facial structure, and encoding and retrieval of facial information. This implies that impaired face recognition can result from failures of face perception, face memory, or both. Studies of acquired prosopagnosia, autism spectrum disorders, and the development of normal face recognition support the idea that face perception and face memory are distinct processes, yet this distinction has received little attention in developmental prosopagnosia (DP). To address this issue, we tested the face perception and face memory of children and adults with DP. By …

Memory Retrieval Is Maintained By Intrinsic And Synaptic Plasticity In Prelimbic Cortex, James Otis

Theses and Dissertations

Abnormally strong memories underlie common disorders including addiction and post-traumatic stress disorder (PTSD). Memory disruption would therefore be beneficial for treatment of these disorders. Evidence reveals that cocaine conditioned place preference (CPP) memories are susceptible to long-lasting disruption during memory retrieval. For example, inhibition of β-adrenergic receptor (β-AR) activity within the prelimbic medial prefrontal cortex (PL-mPFC) prevents cocaine CPP memory retrieval, and this retrieval impairment is both long-lasting and prevents subsequent reinstatement of the CPP. Despite this, whether PL-mPFC β-AR activity is a fundamental mechanism required to maintain retrieval of other memories is unclear. Furthermore, how PL-mPFC β-AR activity maintains …

Spatial And Temporal Response Patterns On The Eight-Arm Radial Maze, Robert H.I. Dale

Robert H. I. Dale

Six maze-experienced hooded rats were timed during five trials on which they collected water from all arms of an eight-arm radial maze, then made five more choices. All subjects frequently exhibited a “task-completion pause:” The subjects rarely spent more than 1 sec in the center of the maze between choices until they had entered all eight arms, then stopped in the center of the maze. In contrast, the time spent in each arm gradually increased until all of the water had been obtained, then decreased slightly. Four subjects began every trial by choosing eight consecutive adjacent arms. The task-completion pause …

The Hippocampus As Episodic Encoder: Does It Play Tag?, Robert H.I. Dale

Robert H. I. Dale

Rawlins’s characterization of the hippocampus as a “high-capacity, immediate-term memory store” captures the essential idea in a number of previous models. For example, Gaffan (1974), Gray (1984), Hirsh (1980), Kesner (Bierley, Kesner & Novak 1983), Olton (Olton, Becker & Handelmann 1979), Solomon (1980), and Winocur (1980) all agree that hippocampal animals show memory deficits when required to identify, for whatever reason, one specific event out of a list of recent events. Although these authors disagree on a number of details, Rawlins has identified their models common ground, the core of each model. (It is only fair to note that Gaffan …

Determining A Correlation Between Individual Differences In Eye Movements And Working Memory, Mackenzie Sunday

Senior Theses

This study determined if a relationship exists between individual differences in eye movements and working memory measures. The eye movement system can provide insight into processes that occur in the mind as well as a better understanding of the relationship between quantifiable aspects of eye movements and the more abstract inner workings of the mind. Recently, consistent and reliable individual differences have been found in individuals’ eye movement behaviors. For example, individuals with longer fixation durations for one visual task have longer fixations across all other visual tasks. The eye movements of participants were collected during four different viewing tasks …

Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang

Theses and Dissertations

Visual searching can be facilitated without awareness when the target is repeatedly presented in an invariant context in tasks such as contextual cueing (Chun & Jiang 1998). A behavioral cost (increased reaction time) was observed when the target was moved to a new location but no such cost was observed when the target returned to the initial location. The lack of cost for return suggests two possible explanations: One is that the learning can update the initial learning to acquire both target locations, which suggests the implicit learning is flexible. The other is that the contextual cue leaning cannot update …

Tethered Il-15 To Augment The Therapeutic Potential Of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, And Antitumor Activity, Lenka Hurton

Dissertations & Theses (Open Access)

Tethered IL-15 to augment the therapeutic potential of T cells expressing chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity

Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by the expression of a chimeric antigen receptor (CAR). Infusion of CAR-modified T cells for the treatment B-cell malignancies has demonstrated promise in preclinical and clinical trials. These data highlight the ability of infused CD19-specific T cells to be synchronously activated by large burdens of CD19⁺ leukemia and lymphoma. This can lead to dramatic antitumor effects, but also exposes the recipient to …

Hemispheric Bases For Emotion And Memory, Tad T. Brunyé, Sarah R. Cavanagh, Ruth E. Propper

Psychology Department Faculty Works

No abstract provided.

Cholesterol-Cholate-Butterfat Diet Offers Multi-Organ Dysfunction In Rats, Humaira Jamshed, Jamshed Arslan, Anwar-Ul-Hassan Gilani

Department of Biological & Biomedical Sciences

Background: Comparable to commercial expensive high-fat diets, cholesterol-cholate-butterfat (CCB) diet has also been used to induce hyperlipidemia in rats. Our objective was to explore its influence on multiple organs. Consequence of fasting was also analysed.
Methods: Rats in groups 1 and 2 received normal diet (ND) whereas groups 3 and 4 received CCB-diet. Food was withdrawn daily for two hours from groups 2 (ND-F) and 4 (CCB-F). Blood was collected at fourth and sixth week for biochemical estimation; Morris water maze was done in the sixth week for learning ability and memory; after which aortae were isolated for vascular reactivity. …

Mediation Of Recurrent Hypoglycemia's Physiological And Behavioral Effects In The Hippocampus By Glucocorticoids, Danielle Osborne

Legacy Theses & Dissertations (2009 - 2024)

Recurrent hypoglycemia (RH) occurs with the over administration of insulin resulting in severe hypoglycemia on a repetitive basis. This occurs most commonly among Type I Diabetics who rely on exogenous insulin replacement for management of their disease; however it is becoming increasingly common among Type II Diabetics. Although cognitive deficits are reported during hypoglycemia, the period following restoration of euglycemia has been denoted by improved hippocampally-mediated short-term and working memory in humans and rodents, respectively. RH is also associated with an altered glucocorticoid secretion profile in response to hypoglycemia. In vitro and in vivo approaches were utilized with the goal …

The Role Of Igf-Ii In Memory Enhancement : Implications For Autism Spectrum Disorders, Amy S. Kohtz

Legacy Theses & Dissertations (2009 - 2024)

Cognitive and memory impairments significantly affect multiple domains in life and play major roles in disease. Identifying critical mechanisms and factors that mediate memory consolidation and enhancement may represent an important approach for increasing cognition in normal adults and preventing or treating cognitive impairments. The expression of the C/EBP- target gene insulin-like growth factor 2, (IGF-II) is required for memory consolidation; furthermore, IGF-II administration during memory consolidation produces memory enhancement, increased memory persistence and prevents forgetting. In this thesis, I investigated the therapeutic potential of IGF-II to promote memory consolidation when administered systemically. In addition, I investigated one particularly interesting …