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The Neuroinflammatory Effects Of Chronic Unpredictable Stress On Zebrafish, Danio Rerio, Brandon Stewart Dec 2020

The Neuroinflammatory Effects Of Chronic Unpredictable Stress On Zebrafish, Danio Rerio, Brandon Stewart

Master of Science in Integrative Biology Theses

Stress is a state of threatened homeostasis counteracted by various physiologic and behavioral responses aimed to maintain or restore balance. As such, stress acts as a motivator to perform during the challenges of life to survive. Chronic perturbations to the stress response homeostasis without relief can lead to dysregulation, thus attenuating organ systems and structures and causing significant damage {1]. Individuals who undergo psychological trauma endure an acute and transient experience, which results in minimal functional impairment, but some suffer from a chronic condition called posttraumatic stress disorder (PTSD). Individuals who have PTSD are likely to experience intense stress, …


Hormonal Responses To Seasonal Thermal And Ecological Stressors In Japanese Macaques (Macaca Fuscata), Lilianne Nelson Dec 2020

Hormonal Responses To Seasonal Thermal And Ecological Stressors In Japanese Macaques (Macaca Fuscata), Lilianne Nelson

Masters Theses

Relative to most primate species, Japanese macaques (Macaca fuscata) experience extreme seasonal variation in thermal and ecological stressors that can impact energetic demands. To cope with these environmental changes, levels of metabolic hormones, such as cortisol and triiodothyronine, fluctuate to facilitate energetic adjustments. While previous research in primates has investigated thermal and ecological stressors individually, a combined assessment of these stressors alongside hormone levels can provide a more holistic understanding of the relationship between a primate’s thermoregulation, energetic balance, and stress. The goals of this study were to determine the effects of season, temperature and ecological stress on …


Predictors Of Psychosocial And Physiological Distress In Colorectal Cancer Patients, Hyrum Eddington Jun 2020

Predictors Of Psychosocial And Physiological Distress In Colorectal Cancer Patients, Hyrum Eddington

Undergraduate Honors Theses

Distress among cancer patients has been broadly accepted as an important indicator of patient well-being. However, questions remain such as what patient characteristics are associated with high distress and whether patient-reported distress is correlated with distress biomarkers. To answer these questions, we performed a survey study of 238 colorectal patients in which we assessed patient-reported distress, possible contributors to that distress, and patient anxiety and depression. We also abstracted demographic and clinical information from patient charts and collected measures for salivary cortisol and sarcopenia. We conducted bivariate statistical analyses between patient demographics, clinical factors, and psychosocial measures with our three …


The Effect Of Slow-Feeding Hay Nets On Post-Prandial Equine Salivary Cortisol Levels, Grace Simpson Apr 2020

The Effect Of Slow-Feeding Hay Nets On Post-Prandial Equine Salivary Cortisol Levels, Grace Simpson

Undergraduate Honors Thesis Projects

Throughout its evolution, the Equus caballus, or horse, developed a physiological response to environmental alterations involving the synthesis and release of cortisol from the hypothalamic-pituitary-adrenal axis, to regulate blood glucose levels, vascular tone and hormone release throughout the body (Ambrojo et al., 2018). With a hypothesis that changing a horse’s feeding method can alter salivary cortisol levels, the aim of this research project was to determine if feeding forage to horses in slow-feeding haynets would significantly reduce acute cortisol salivary level fluctuations, which would be valuable to minimize horses’ stress and increase overall welfare. Two feeding methods …


Effect Of The Prospect Of Transport On Captive Tiger Behavior And Fecal Cortisol In Naïve And Experienced Tigers, Callan Lichtenwalter Jan 2020

Effect Of The Prospect Of Transport On Captive Tiger Behavior And Fecal Cortisol In Naïve And Experienced Tigers, Callan Lichtenwalter

Graduate Theses and Dissertations

With close to 5,000 captive tigers in the United States, it is vital to ensure that these tigers are receiving adequate welfare whether they are in an accredited facility, or privately owned. The goal of this study was to assess whether captive tigers at a rescue facility with experience being transported outside of the facility would respond differently to the presentation of their transport vehicle than their naïve counterparts who had only been transported within the facility. The behavior of 5 naïve and 7 experienced tigers (n = 12) located at Turpentine Creek Wildlife Refuge in Eureka Springs, Arkansas was …


Identifying Metabolites As Markers Of Fatigue In Athletes, Christopher D. George Jan 2020

Identifying Metabolites As Markers Of Fatigue In Athletes, Christopher D. George

Honors Theses

Fatigue in athletes caused by inadequate rest and other stressors can be severely detrimental to their health, and yet there is no reliable way to measure and track fatigue. Many classical measures of fatigue like body mass and resting heart rate are not reliable ways to track the physical fatigue of an athlete because they can change with many factors. In addition, it is not known how academic stress on top of physical stress affects fatigue. Metabolomics is a relatively new area of study and tracking metabolites offers the possibility to produce biomarkers to assess fatigue. This study collected saliva …