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The Preparation And Characterization Of Diastereomeric (+)-Quinicinol, Ronald Timpe

University of the Pacific Theses and Dissertations

Female Anopheles mosquitoes are the only known vectors of human malaria (1) so that eradication of the disease depends on either eliminating the Anopheles mosquito or controlling the Plasmodium organism. In the U.S., Fiji Islands, Hawaii, and Guam, the absence of malaria is due to the absence or elimination of the Anopheles (1). Where the mosquito is less easily eliminated, the Plasmodium parasite must be controlled, and so the quest for effective antiplasmodial drugs is a continuing effort. More than 20,000 drugs (1), 14,000 of which were investigated between 1941-1945 (2), have been studied in regard to their aniplasmodial effect. …