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E-Cadherin Might Be A Stage-Dependent Modulator In Aggressiveness In Pancreatic Cancer Cells, Esra Aydemi̇r Çoban, Di̇dem Teci̇mel, Ezgi̇ Kaşikci, Ömer Faruk Bayrak, Fi̇kretti̇n Şahi̇n
E-Cadherin Might Be A Stage-Dependent Modulator In Aggressiveness In Pancreatic Cancer Cells, Esra Aydemi̇r Çoban, Di̇dem Teci̇mel, Ezgi̇ Kaşikci, Ömer Faruk Bayrak, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in …
Comparison Of Anticarcinogenic Properties Of Viburnum Opulus And Its Active Compound P-Coumaric Acid On Human Colorectal Carcinoma, Serdar Karakurt, Gülsüm Abuşoğlu, Zeki̇ye Ceren Arituluk
Comparison Of Anticarcinogenic Properties Of Viburnum Opulus And Its Active Compound P-Coumaric Acid On Human Colorectal Carcinoma, Serdar Karakurt, Gülsüm Abuşoğlu, Zeki̇ye Ceren Arituluk
Turkish Journal of Biology
Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticarcinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active compound, trans-p-coumaric acid (p-CA), on human colon cancer cells (DLD-1, HT-29, SW-620, Caco-2) and healthy colon epithelial cells (CCD-18Co). The effects of EVO on controlled cell death (apoptosis) and the cell division cycle were determined by flow cytometry. Alteration in mRNA and protein expressions of switch genes …
Caffeic Acid Phenethyl Ester Induces Apoptosis In Colorectal Cancer Cells Via Inhibition Of Survivin, Ceren Sari, Ceren Sümer, Fi̇gen Celep Eyüpoğlu
Caffeic Acid Phenethyl Ester Induces Apoptosis In Colorectal Cancer Cells Via Inhibition Of Survivin, Ceren Sari, Ceren Sümer, Fi̇gen Celep Eyüpoğlu
Turkish Journal of Biology
Colorectal cancer is one of the most common types of cancer. Drug resistance and drug-induced damage of healthy tissues are major obstacles in cancer treatment. Therefore, to develop efficient anticancer therapy, it is necessary to find compounds that affect tumor cells, but do not exhibit toxicity to healthy cells. Caffeic acid phenethyl ester (CAPE) has been demonstrated to have anticancer properties in many types of cancer. In this study, the cytotoxic and apoptotic effects of CAPE on the RKO colorectal cancer cell line and CCD 841-CoN normal colorectal cell line was investigated. In addition, changes in the survivin expression were …
Anxiolytic, Antioxidant, And Neuroprotective Effects Of Goji Berry Polysaccharides In Ovariectomized Rats: Experimental Evidence From Behavioral, Biochemical, And Immunohistochemical Analyses, Fatma Pehli̇van Karakaş, Hami̇t Coşkun, Hayri̇ye Soytürk, Bi̇hter Gökçe Bozat
Anxiolytic, Antioxidant, And Neuroprotective Effects Of Goji Berry Polysaccharides In Ovariectomized Rats: Experimental Evidence From Behavioral, Biochemical, And Immunohistochemical Analyses, Fatma Pehli̇van Karakaş, Hami̇t Coşkun, Hayri̇ye Soytürk, Bi̇hter Gökçe Bozat
Turkish Journal of Biology
Recent studies have indicated that polysaccharides, the main component of the Lycium barbarum L. fruit, have beneficial effects (e.g., anxiolytic, antioxidant, and neuroprotective) on humans and rodents. However, the effects of different dosages of such polysaccharides on ovariectomized rats and their underlying mechanisms in the brain have not been evaluated in the literature. Here, we aimed to evaluate the effects of the high and low doses of polysaccharides obtained from Lycium barbarum fruits (HD-LBP and LD-LBP, respectively) on anxious behaviors via behavioral (using the OFT and EPM), biochemical (using ELISA), and immunohistochemical (using immunohistochemical staining) measures in detail. Two weeks …
Upregulation Of Psmd4 Gene By Hypoxia In Prostate Cancer Cells, Sümeyye Aydogan Türkoğlu, Gi̇zem Dayi, Feray Köçkar
Upregulation Of Psmd4 Gene By Hypoxia In Prostate Cancer Cells, Sümeyye Aydogan Türkoğlu, Gi̇zem Dayi, Feray Köçkar
Turkish Journal of Biology
Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. PSMD4 overexpression has been observed in colon carcinoma, hepatocellular carcinoma, and breast cancer. In this work, we elucidated the effect of hypoxia on PSMD4 gene expression in prostate cancer cells (PC3). Chemically mimicked hypoxia drastically upregulated PSMD4 gene expression at both mRNA and protein levels. Transient transfection experiments indicated that all promoter fragments were active in PC3 cells. Hypoxia increased transcriptional activity of all PSMD4 promoter constructs. …
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Turkish Journal of Biology
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and …
Regulation Of E2f1 Activity Via Pka-Mediated Phosphorylations, Mustafa Gökhan Ertosun, Sayra Di̇lmaç, Fatma Zehra Hapi̇l Zevkli̇ler, Gamze Tanriöver, Sadi̇ Köksoy, Osman Ni̇dai̇ Özeş
Regulation Of E2f1 Activity Via Pka-Mediated Phosphorylations, Mustafa Gökhan Ertosun, Sayra Di̇lmaç, Fatma Zehra Hapi̇l Zevkli̇ler, Gamze Tanriöver, Sadi̇ Köksoy, Osman Ni̇dai̇ Özeş
Turkish Journal of Biology
No abstract provided.
Effects Of Moderate High Temperature And Uv-B On Accumulation Of Withanolides And Relative Expression Of The Squalene Synthase Gene In Physalis Peruviana, Günce Şahi̇n, Murat Telli̇, Ercan Selçuk Ünlü, Fatma Pehli̇van Karakaş
Effects Of Moderate High Temperature And Uv-B On Accumulation Of Withanolides And Relative Expression Of The Squalene Synthase Gene In Physalis Peruviana, Günce Şahi̇n, Murat Telli̇, Ercan Selçuk Ünlü, Fatma Pehli̇van Karakaş
Turkish Journal of Biology
Physalis peruviana L. (Cape gooseberry) is a source for a variety of phytocompounds such as withanolides, withanone, withaferin A, and withanolide A. These withanolides are high-value drug candidates due to their various pharmacological properties. To meet the increasing demands for these compounds, plant cell technology offers a reliable alternative. Exogenous addition of elicitors is considered the most effective strategy for enhanced production of secondary metabolites. In this study, we investigated changes in withanolide accumulation and characterized the gene expression level changes of squalene synthase enzyme in P. peruviana shoot cultures exposed to mild nonlethal heat stress (45°C for 2 and …
In Vitro Tooth-Shaped Scaffold Construction By Mimicking Late Bell Stage, Paki̇ze Nesli̇han Taşli, Gül Merve Yalçin Ülker, Alev Cumbul, Ünal Uslu, Şahi̇n Yilmaz, Batuhan Turhan Bozkurt, Fi̇kretti̇n Şahi̇n
In Vitro Tooth-Shaped Scaffold Construction By Mimicking Late Bell Stage, Paki̇ze Nesli̇han Taşli, Gül Merve Yalçin Ülker, Alev Cumbul, Ünal Uslu, Şahi̇n Yilmaz, Batuhan Turhan Bozkurt, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Neogenesis of osseous and ligamentous interfacial structures is essential for the regeneration of large oral or craniofacial defects. However, current treatment strategies are inadequate in renewing supporting tissues of teeth after trauma, chronic infections or surgical resection. Combined use of 3D scaffolds with stem cells became a promising treatment option for these injuries. Matching different scaffolding materials with different tissues can induce the correct cytokines and the differentiation of cells corresponding to that particular tissue. In this study, a hydroxyapatite (HA) based scaffold was used together with human adipose stem cells (hASCs), human bone marrow stem cells (hBMSCs) and gingival …
Adjuvant Potency Of Astragaloside Vii Embedded Cholesterol Nanoparticles For H3n2 Influenza Vaccine, Rükan Genç, Ni̇lgün Yakuboğullari, Ayşe Nalbantsoy, Fethi̇ye Çöven, Erdal Bedi̇r
Adjuvant Potency Of Astragaloside Vii Embedded Cholesterol Nanoparticles For H3n2 Influenza Vaccine, Rükan Genç, Ni̇lgün Yakuboğullari, Ayşe Nalbantsoy, Fethi̇ye Çöven, Erdal Bedi̇r
Turkish Journal of Biology
Adjuvants are substances that increase the immune response to a given antigen. In the development of novel vaccine adjuvants/ systems, saponins are one of the most attractive molecules due to their altered immunomodulatory activities. In this study, we tried to develop PEG (polyethylene glycol)/cholesterol-based lipid nanoparticles (LNPs) to deliver the Astragaloside VII (AST-VII) and potentiate adjuvant properties of AST-VII for the influenza vaccine. In the formation of PEG/cholesterol/AST-VII-based LNPs (PEG300: Chol-AST-VII LNPs), 3 different primary solvents (acetone, ethanol, and chloroform) were evaluated, employing their effects on hydrodynamic particle size, distribution, surface chemistry, and colloidal stability. Prepared nanoparticles were simply admixtured …
Transcriptional Splice Variants Of Cd40 And Its Prognostic Value In Breast Cancer, Neşe Ünver, Di̇ğdem Yöyen Ermi̇ş, Bahar Zehra Weber, Güneş Esendağli
Transcriptional Splice Variants Of Cd40 And Its Prognostic Value In Breast Cancer, Neşe Ünver, Di̇ğdem Yöyen Ermi̇ş, Bahar Zehra Weber, Güneş Esendağli
Turkish Journal of Biology
CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype. We detected CD40 gene expression along with its 3 different splice variants …
Proximity Mapping Of The Microtubule Plus-End Tracking Protein Slain2 Using The Bioid Approach, Eli̇f Nur Firat Karalar
Proximity Mapping Of The Microtubule Plus-End Tracking Protein Slain2 Using The Bioid Approach, Eli̇f Nur Firat Karalar
Turkish Journal of Biology
No abstract provided.
Interaction Of Influenza A Virus Ns2/Nep Protein With The Amino-Terminal Part Of Nup214, Burçak Şenbaş Akyazi, Ayşegül Pi̇ri̇nçal, Atsushi Kawaguchi, Kyosuke Nagata, Kadi̇r Turan
Interaction Of Influenza A Virus Ns2/Nep Protein With The Amino-Terminal Part Of Nup214, Burçak Şenbaş Akyazi, Ayşegül Pi̇ri̇nçal, Atsushi Kawaguchi, Kyosuke Nagata, Kadi̇r Turan
Turkish Journal of Biology
Influenza A viruses have a single-stranded RNA genome consisting of 8 segments. Each RNA segment associates with the nucleoprotein (NP) and viral RNA polymerase to and from a viral ribonucleoprotein (vRNP) particle. The viral mRNA synthesis is dependent on a capped primer derived from nascent host RNA transcripts. For these processes to take place, vRNPs must pass through the cell nuclear pore complex (NPC) to the nucleus. The influenza A virus NS2 protein, also called the nuclear export protein (NES), has an important role in the nucleocytoplasmic transport of vRNPs. This protein interacts with the host cellular nucleoporins during the …
Pkr Inhibitors Suppress Endoplasmic Reticulum Stress And Subdue Glucolipotoxicitymediated Impairment Of Insulin Secretion In Pancreatic Beta Cells, Abdullah Yalçin, Gülçi̇n Şarkici, Umut Kerem Kolaç
Pkr Inhibitors Suppress Endoplasmic Reticulum Stress And Subdue Glucolipotoxicitymediated Impairment Of Insulin Secretion In Pancreatic Beta Cells, Abdullah Yalçin, Gülçi̇n Şarkici, Umut Kerem Kolaç
Turkish Journal of Biology
Type 2 diabetes mellitus is characterized by insulin resistance and hypersecretion of insulin from the pancreas to compensate for decreased insulin sensitivity in the peripheral tissues. In later stages of the disease insulin-secreting beta cell degeneration commences and patients require insulin replacement therapy in order to accomplish proper regulation of their blood glucose. Endoplasmic reticulum (ER) stress in the beta cells is one of the factors contributing to this detrimental effect. Protein kinase R (PKR) is a cellular stress kinase activated by ER stress and contributing to degeneration of pancreatic islets. In order to determine whether inhibition of PKR activation …
Msap Analysis Reveals Diverse Epigenetic Statuses In Opium Poppy Varieties With Different Benzyisoquinoline Alkaloid Content, Betül Bulut, Zehra Aydinli, Mi̇ne Türktaş
Msap Analysis Reveals Diverse Epigenetic Statuses In Opium Poppy Varieties With Different Benzyisoquinoline Alkaloid Content, Betül Bulut, Zehra Aydinli, Mi̇ne Türktaş
Turkish Journal of Biology
DNA methylation is one of the major epigenetic modifications influencing the regulation of gene expression. The opium poppy is an important medicinal plant. Its latex contains opium, which is a rich source of pharmaceutical benzyisoquinoline alkaloids (BIA). Here, the methylation-sensitive amplification polymorphism (MSAP) profiling technique using 21 MSAP molecular markers was applied in order to compare levels of DNA methylation between 6 opium poppy varieties. MSAP profiling reflected the different methylation statuses among opium poppy varieties having divergent BIA content. Moreover, different organ-specific epigenetic profiles were observed between the samples. Differential epigenetic profiles of capsules and shoots from the leaves …
Bioethical Issues In Genome Editing By Crispr-Cas9 Technology, Fatma Betül Ayanoğlu, Ayşe Eser Elçi̇n, Yaşar Murat Elçi̇n
Bioethical Issues In Genome Editing By Crispr-Cas9 Technology, Fatma Betül Ayanoğlu, Ayşe Eser Elçi̇n, Yaşar Murat Elçi̇n
Turkish Journal of Biology
Genome editing technologies have led to fundamental changes in genetic science. Among them, CRISPR-Cas9 technology particularly stands out due to its advantages such as easy handling, high accuracy, and low cost. It has made a quick introduction in fields related to humans, animals, and the environment, while raising difficult questions, applications, concerns, and bioethical issues to be discussed. Most concerns stem from the use of CRISPR-Cas9 to genetically alter human germline cells and embryos (called germline genome editing). Germline genome editing leads to serial bioethical issues, such as the occurrence of undesirable changes in the genome, from whom and how …
Biosafety And Biosecurity Approaches To Restrain/Contain And Counter Sars-Cov-2/Covid-19 Pandemic: A Rapid-Review, Tauseef Ahmad, Haroon Haroon, Kuldeep Dhama, Khan Sharun, Fazal Mehmood Khan, Irfan Ahmed, Ruchi Tiwari, Taha Hussein Musa, Muhammad Khan, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales, Jin Hui
Biosafety And Biosecurity Approaches To Restrain/Contain And Counter Sars-Cov-2/Covid-19 Pandemic: A Rapid-Review, Tauseef Ahmad, Haroon Haroon, Kuldeep Dhama, Khan Sharun, Fazal Mehmood Khan, Irfan Ahmed, Ruchi Tiwari, Taha Hussein Musa, Muhammad Khan, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales, Jin Hui
Turkish Journal of Biology
Emergence and reemergence of infectious diseases pose significant public health risks that are continuously haunting human civilization in the past several decades. Such emerging pathogens should be considered as a high threat to humans, animals, and environmental health. The year 2020 was welcomed by another significant virus from family Coronaviridae called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19). The disease was first reported in the city of Wuhan, Hubei province, China. Within a short time, this disease attained the status of the Public Health Emergency of International Concern. Presently, COVID-19 has spread to …
Phylogenetic Analysis Of Sars-Cov-2 Genomes In Turkey, Ogün Adebali̇, Ayli̇n Bi̇rcan, Defne Çi̇rci̇, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
Phylogenetic Analysis Of Sars-Cov-2 Genomes In Turkey, Ogün Adebali̇, Ayli̇n Bi̇rcan, Defne Çi̇rci̇, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
Turkish Journal of Biology
COVID-19 has effectively spread worldwide. As of May 2020, Turkey is among the top ten countries with the most cases. A comprehensive genomic characterization of the virus isolates in Turkey is yet to be carried out. Here, we built a phylogenetic tree with globally obtained 15,277 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes. We identified the subtypes based on the phylogenetic clustering in comparison with the previously annotated classifications. We performed a phylogenetic analysis of the first 30 SARS-CoV-2 genomes isolated and sequenced in Turkey. We suggest that the first introduction of the virus to the country is earlier …
An Updated Analysis Of Variations In Sars-Cov-2 Genome, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
An Updated Analysis Of Variations In Sars-Cov-2 Genome, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
Turkish Journal of Biology
A novel pathogen, named SARS-CoV-2, has caused an unprecedented worldwide pandemic in the first half of 2020. As the SARS-CoV-2 genome sequences have become available, one of the important focus of scientists has become tracking variations in the viral genome. In this study, 30366 SARS-CoV-2 isolate genomes were aligned using the software developed by our group (ODOTool) and 11 variations in SARS-CoV-2 genome over 10% of whole isolates were discussed. Results indicated that, frequency rates of these 11 variations change between 3.56%-88.44 % and these rates differ greatly depending on the continents they have been reported. Despite some variations being …
Identification Of The Nucleotide Substitutions In 62 Sars-Cov-2 Sequences From Turkey, Ayşe Banu Demi̇r, Domenico Benvenuto, Yusuf Hakan Abacioğlu, Silvia Angeletti, Massimo Ciccozzi
Identification Of The Nucleotide Substitutions In 62 Sars-Cov-2 Sequences From Turkey, Ayşe Banu Demi̇r, Domenico Benvenuto, Yusuf Hakan Abacioğlu, Silvia Angeletti, Massimo Ciccozzi
Turkish Journal of Biology
A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause coronavirus disease 2019 (COVID-19) pandemic. The first case of COVID-19 in Turkey has been declared in March 11th, 2020 and from there on, more than 150,000 people in the country have been diagnosed with the disease. In this study, 62 viral sequences from Turkey, which have been uploaded to GISAID database, were analyzed by means of their nucleotide substitutions in comparison to the reference SARS-CoV-2 genome from Wuhan. Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral …
An Insight Into The Epitope-Based Peptide Vaccine Design Strategy And Studies Against Covid-19, Murat Topuzoğullari, Tayfun Acar, Peli̇n Peli̇t Arayici, Burcu Uçar, Erennur Uğurel, Emrah Şefi̇k Abamor, Tüli̇n Arasoğlu, Di̇lek Balik, Serap Derman
An Insight Into The Epitope-Based Peptide Vaccine Design Strategy And Studies Against Covid-19, Murat Topuzoğullari, Tayfun Acar, Peli̇n Peli̇t Arayici, Burcu Uçar, Erennur Uğurel, Emrah Şefi̇k Abamor, Tüli̇n Arasoğlu, Di̇lek Balik, Serap Derman
Turkish Journal of Biology
SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020. It is crucial to design and produce an effective vaccine for the prevention of rapid transmission and possible deaths wcaused by the disease. Although intensive work and research are being carried out all over the world to develop a vaccine, an effective and approved formulation that can prevent the infection and limit the outbreak has not been announced yet. Among all types of vaccines, epitope-based peptide vaccines outshine with their low-cost production, easy modification in the structure, and safety. In …
Potentials Of Plant-Based Substance To Inhabit And Probable Cure For The Covid-19, Israt Jahan, Ahmet Onay
Potentials Of Plant-Based Substance To Inhabit And Probable Cure For The Covid-19, Israt Jahan, Ahmet Onay
Turkish Journal of Biology
COVID-19 has been the most devastating pandemic in human history. Despite the highest scientific efforts and investments, a reliable and certified medication has yet to be developed regarding to immune or cure this virus. However, while synthetic medications are gaining the focus of attentions, it appears from a significant number of recent studies that plant-based substances could also be potential candidates for developing effective and secure remedies against this novel disease. Citing such recent works, this review primarily demonstrates the antiviral potentials of medicinal plants for inhibiting human coronaviruses. It also shows the importance of antiviral plants substances, particularly in …
Integration Of Transcriptomic Profile Of Sars-Cov-2 Infected Normal Human Bronchial Epi-Thelial Cells With Metabolic And Protein-Protein Interaction Networks, Hamza Umut Karakurt, Pinar Pi̇r
Integration Of Transcriptomic Profile Of Sars-Cov-2 Infected Normal Human Bronchial Epi-Thelial Cells With Metabolic And Protein-Protein Interaction Networks, Hamza Umut Karakurt, Pinar Pi̇r
Turkish Journal of Biology
A novel coronavirus (SARS-CoV-2, formerly known as nCoV-2019) that causes an acute respiratory disease has emerged in Wuhan, China and spread globally in early 2020. On January the 30th, the World Health Organization (WHO) declared spread of this virus as an epidemic and a public health emergency. With its highly contagious characteristic and long incubation time, confinement of SARS-CoV-2 requires drastic lock-down measures to be taken and therefore early diagnosis is crucial. We analysed transcriptome of SARS-CoV-2 infected human lung epithelial cells, compared it with mock-infected cells, used network-based reporter metabolite approach and integrated the transcriptome data with protein-protein interaction …
Sars-Cov-2 Neutralizing Antibody Development Strategies, Bertan Koray Balcioğlu, Meli̇s Deni̇zci̇ Öncü, Hasan Ümi̇t Öztürk, Fatima Yücel, Fi̇li̇z Kaya, Müge Serhatli, Hi̇vda Ülbeği̇ Polat, Şaban Teki̇n, Ayli̇n Özdemi̇r Bahadir
Sars-Cov-2 Neutralizing Antibody Development Strategies, Bertan Koray Balcioğlu, Meli̇s Deni̇zci̇ Öncü, Hasan Ümi̇t Öztürk, Fatima Yücel, Fi̇li̇z Kaya, Müge Serhatli, Hi̇vda Ülbeği̇ Polat, Şaban Teki̇n, Ayli̇n Özdemi̇r Bahadir
Turkish Journal of Biology
In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 2020. The virus spread triggered a health crisis (the COVID-19 disease) within three months, with socioeconomic implications. No approved targeted-therapies are available for COVID-19, yet. However, it is foreseen that antibody-based treatments may provide an immediate cure for patients. Current neutralizing antibody development studies primarily …
Covid-19: Current Knowledge, Disease Potential, Prevention And Clinical Advances, Aftab Alam, Mohd Faizan Siddiqui, Nikhat Imam, Rafat Ali, Mushtaque Mushtaque, Romana Ishrat
Covid-19: Current Knowledge, Disease Potential, Prevention And Clinical Advances, Aftab Alam, Mohd Faizan Siddiqui, Nikhat Imam, Rafat Ali, Mushtaque Mushtaque, Romana Ishrat
Turkish Journal of Biology
The top priority of any nation is to lead the nation towards prosperity, progress, and economic growth, confronting several challenges and concerns arisen from global situations. The sudden outbreak of any disease defies the health care systems and economy of nations. COVID-19 is one of the viral diseases which broke out in Wuhan city of China in 2019. COVID-19 outbreak intermittently prevailed all over the world. It exposes the fragility of the established health care systems across the world in spite of comprising modern science and technology. Unfortunately, there is no chemotherapeutic agent in the regimen of antiviral drugs or …
Sars-Cov-2 Isolation And Propagation From Turkish Covid-19 Patients, Ci̇han Taştan, Bulut Yurtsever, Gözde Karakuş, Derya Di̇lek Kançaği, Sevda Demi̇r, Selen Abanuz, Utku Seyi̇s, Mülazi̇m Yildirim, Recai̇ Kuzay, Ömer Eli̇bol, Serap Arbak, Merve Açikel Elmas, Selçuk Bi̇rdoğan, Osman Uğur Sezerman, Ayşe Sesi̇n Kocagöz
Sars-Cov-2 Isolation And Propagation From Turkish Covid-19 Patients, Ci̇han Taştan, Bulut Yurtsever, Gözde Karakuş, Derya Di̇lek Kançaği, Sevda Demi̇r, Selen Abanuz, Utku Seyi̇s, Mülazi̇m Yildirim, Recai̇ Kuzay, Ömer Eli̇bol, Serap Arbak, Merve Açikel Elmas, Selçuk Bi̇rdoğan, Osman Uğur Sezerman, Ayşe Sesi̇n Kocagöz
Turkish Journal of Biology
The novel coronavirus pneumonia, which was named later as coronavirus disease 2019 (COVID-19), is caused by the severe acute respiratory syndrome coronavirus 2, namely SARS-CoV-2. It is a positive-strand RNA virus that is the seventh coronavirus known to infect humans. The COVID-19 outbreak presents enormous challenges for global health behind the pandemic outbreak. The first diagnosed patient in Turkey has been reported by the Republic of Turkey Ministry of Health on March 11, 2020. In May, over 150,000 cases in Turkey, and 5.5 million cases around the world have been declared. Due to the urgent need for a vaccine and …
Interaction Of Certain Monoterpenoid Hydrocarbons With The Receptor Binding Domain Of 2019 Novel Coronavirus (2019-Ncov), Transmembrane Serine Protease 2 (Tmprss2), Cathepsin B, And Cathepsin L (Catb/L) And Their Pharmacokinetic Properties, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Cengi̇z Sarikürkcü, Bektaş Tepe
Interaction Of Certain Monoterpenoid Hydrocarbons With The Receptor Binding Domain Of 2019 Novel Coronavirus (2019-Ncov), Transmembrane Serine Protease 2 (Tmprss2), Cathepsin B, And Cathepsin L (Catb/L) And Their Pharmacokinetic Properties, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Cengi̇z Sarikürkcü, Bektaş Tepe
Turkish Journal of Biology
As of June 2020, the coronavirus disease 19 (COVID-19) caused by the 2019 new type coronavirus (2019-nCoV) infected more than 7,000,000 people worldwide and caused the death of more than 400,000 people. The aim of this study was to investigate the molecular interactions between monoterpenoids and spike protein of 2019-nCoV together with the cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B (CatB), and cathepsin L (CatL)]. As a result of the relative binding capacity index (RBCI) analysis, carvone was found to be the most effective molecule against all targets when binding energy and predicted (theoretical) IC50 data were evaluated …
Gut-Lung Axis And Dysbiosis In Covid-19, Büşra Aktaş, Belma Aslim
Gut-Lung Axis And Dysbiosis In Covid-19, Büşra Aktaş, Belma Aslim
Turkish Journal of Biology
COVID-19, a novel infectious disease, caused by SARS-CoV-2, affected millions of people around the world with a high mortality rate. Although SARS-CoV-2 mainly causes lung infection, gastrointestinal symptoms described in COVID-19 patients and detection of the viral RNA in feces of infected patients drove attentions to a possible fecal-oral transmission route of SARS-CoV-2. However, not only the viral RNA but also the infectious viral particles are required for the viral infection and no proof has been demonstrated the transmission of the infectious virus particles via the fecal-oral route yet. Growing evidence indicates the crosstalk between gut microbiota and lung, that …
Mesenchymal Stem Cell Derived Extracellular Vesicles: Promising Immunomodulators Against Autoimmune, Autoinflammatory Disorders And Sars-Cov-2 Infection, Ozlem Bulut, İhsan Gürsel
Mesenchymal Stem Cell Derived Extracellular Vesicles: Promising Immunomodulators Against Autoimmune, Autoinflammatory Disorders And Sars-Cov-2 Infection, Ozlem Bulut, İhsan Gürsel
Turkish Journal of Biology
Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading to lung pathology and mortality during the ongoing viral pandemic. Mesenchymal stem/stromal cells (MSCs), highly regarded for their regenerative capacities, also possessesremarkable immunoregulatory functions affecting all types of innate and adaptive immune cells. Owing to that, MSCs have been heavily investigated in clinic for the treatment of autoimmune and inflammatory diseases along with transplant rejection. Extensive research in the last decaderevealed that MSCs carry out most of their functions through paracrine factors …
Coculture Model Of Blood-Brain Barrier On Electrospun Nanofibers, Mustafa Görkem Özyurt, Ece Bayir, Şule Doğan, Şükrü Öztürk, Ayli̇n Şendemi̇r
Coculture Model Of Blood-Brain Barrier On Electrospun Nanofibers, Mustafa Görkem Özyurt, Ece Bayir, Şule Doğan, Şükrü Öztürk, Ayli̇n Şendemi̇r
Turkish Journal of Biology
The blood-brain barrier (BBB) is a control mechanism that limits the diffusion of many substances to the central nervous system (CNS). In this study, we designed an in-vitro 3-dimensional BBB system to obtain a fast and reliable model to mimic drug delivery characteristics of the CNS. A support membrane of polycaprolactone nanofiber surfaces was prepared using electrospinning. After confirming the fiber morphology and size, endothelial cells (HUVEC) and glial cells were cultured on either side of this membrane. The model's similarity to in vivo physiology was tested with a home-designed transmembrane resistance (TR) device, with positive and negative control molecules. …