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Erythrocyte-Associated Transients In Capillary Po2 In The Rat Spinotrapezius Muscle During Hemodilution With Hespan And A Hemoglobin-Based Oxygen Carrier, Matthew Barker
Theses and Dissertations
Hemoglobin-based oxygen carriers for use as transfusion fluids have emerged as a leading technology directed at stemming shortages of a safe blood supply and providing a readily available resuscitation fluid in various trauma situations. The purpose of this investigation was to determine the effects of isovolemic hemodilution with Hespan and a hemoglobin-based oxygen carrier (HBOC) on erythrocyte-associated transients (EATs) in capillary PO2. The particulate nature of blood flow in capillaries, when observed from a stationary observation point, results in fluctuations of PO2 as alternating red blood cells and plasma gaps move through the detection region. Therefore, through experimental methods which …
The Effect Of Red Blood Cell Velocity On Oxygenation Measurements Using Resonance Raman Spectroscopy, Derrick Williams
The Effect Of Red Blood Cell Velocity On Oxygenation Measurements Using Resonance Raman Spectroscopy, Derrick Williams
Theses and Dissertations
Resonance Raman spectroscopy can be used to estimate the hemoglobin oxygen saturation. Previous studies have demonstrated that exposure of oxygenated red blood cells to laser illumination may result in photo-induced displacement of oxygen from hemoglobin. In this study, an in vitro model was used to evaluate the relationship between this photo-induced effect and the red blood cell velocity. A computer-controlled system was implemented to acquire variables such as red cell velocity, microvessel diameter and hemoglobin oxygen saturation at multiple sites in selected microvascular networks. Using this system, resonance Raman spectroscopy was employed to measure hemoglobin oxygen saturation gradients in arterioles …