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Regulated Histone H3 Proteolysis During Mouse Embryonic Stem Cell Differentiation, Elizabeth M. Duncan
Regulated Histone H3 Proteolysis During Mouse Embryonic Stem Cell Differentiation, Elizabeth M. Duncan
Student Theses and Dissertations
The association of genomic DNA with histone proteins in the three-dimensional structure known as chromatin is the central framework for “epigenetics,†which is defined as inherited phenotypes governed by differences that cannot be explained by changes in DNA sequence. In recent years, studies have shown that regulated changes in the chemical and physical properties of chromatin often lead to dynamic changes in many cellular processes, including development and differentiation, by affecting the accessibility of the genomic information stored in the DNA. The cell uses many different mechanisms to regulate chromatin in order to establish, maintain, and propagate patterns of gene …
Regulation Of The Heterochromatin Protein 1 By Phosphorylation Of Histone H3 And The Hp1 Hinge Domain, Holger Dormann
Regulation Of The Heterochromatin Protein 1 By Phosphorylation Of Histone H3 And The Hp1 Hinge Domain, Holger Dormann
Student Theses and Dissertations
Chromatin, a polymer formed from DNA, histones, and associated proteins, is the physiological form of genetic information in all eukaryotic cells. Posttranslational modification of histones, such as acetylation, methylation, and phosphorylation, regulates various DNA-dependent processes, ranging from transcription to replication, DNA repair, and apoptosis. A key mechanism by which histone modifications exert these effects is by recruitment of specific binding partners (effector proteins), that in turn direct downstream functions. Insight into the underlying mechanisms are of great importance for a full understanding of chromatin structure and function. One of these effector proteins, Heterochromatin Protein 1 (HP1), plays important roles in …