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Fumarate Inhibits Tnf-Α Release, Megan Kelly
Fumarate Inhibits Tnf-Α Release, Megan Kelly
Seton Hall University Dissertations and Theses (ETDs)
Vertebrates utilize two forms of immunity to combat pathogens. Innate immunity is considered the first line of defense that utilizes immediate action and three barriers. Innate immunity responses typically occur within minutes of pathogen exposure resulting in cellular receptor activation and acute pro-inflammatory cytokine release. Inflammatory macrophages engage bacterial endotoxins, including Gram-negative lipopolysaccharide (LPS) and Gram-positive lipoteichoic acid (LTA). And respond by releasing tumor necrosis factor-α (TNF-α). While beneficial for neutralizing acute pathogen exposure, prolonged TNF-α release results in chronic inflammation and tissue damage. In the present study, we examined two methylated derivatives of a citric acid cycle intermediate, fumarate, …
Rna Interference Targeting Glucose-Regulated-Protein 78 Induces Hepg2 Cell Apoptosis, Brittany Blackman
Rna Interference Targeting Glucose-Regulated-Protein 78 Induces Hepg2 Cell Apoptosis, Brittany Blackman
Seton Hall University Dissertations and Theses (ETDs)
Cancer is a complex genetic disease that is driven by genetic mutations resulting in chronic, inappropriate cell proliferation. Many current cancer therapies lack specificity towards tumor tissues, ultimately leading to adverse side effects and limited clinical efficacy. Recently, selective cancer cell therapy has examined a well-characterized cell surface marker that is preferentially expressed on tumor cells. The over-expression of an endoplasmic reticulum chaperone protein, 78-kDa glucose-regulated-protein (GRP78), has been observed on the surface of cancer cells, but not on normal tissues. By selectively targeting GRP78 with short-interfering RNA (siRNA), potent GRP78 silencing is anticipated by the RNA interference (RNAi) pathway. …
Identification Of The Interaction Between Rack1-Pcbp1 And Characterization Of The Novel Functional Effect Of The Interaction, Pranjal Nahar-Gohad
Identification Of The Interaction Between Rack1-Pcbp1 And Characterization Of The Novel Functional Effect Of The Interaction, Pranjal Nahar-Gohad
Seton Hall University Dissertations and Theses (ETDs)
No abstract provided.
The Effects Of Nickel Chloride Stress On Freshwater Cyanobacterium Synechococcus Sp. Iu 625, Brian Nohomovich
The Effects Of Nickel Chloride Stress On Freshwater Cyanobacterium Synechococcus Sp. Iu 625, Brian Nohomovich
Seton Hall University Dissertations and Theses (ETDs)
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