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Electrical Stimulation Uses Sodium Channel Dependent Depolarization To Produce Exocytotic-Like Dopamine Release And Rotational Behavior In Vivo, Alice Elaine Hernandez
Electrical Stimulation Uses Sodium Channel Dependent Depolarization To Produce Exocytotic-Like Dopamine Release And Rotational Behavior In Vivo, Alice Elaine Hernandez
Open Access Theses & Dissertations
The goal of this project was to establish Electrical Stimulation (ES) in combination with In Vivo Intracerebral Microdialysis (IVMCD) as a methodology to evoke exocytotic-like dopamine (DA) release. To provide evidence that ES mimics action potential-mediated DA exocytosis, we hypothesized that ES produces depolarization of the membrane potential that is dependent upon sodium (Na+) -channels to produce DA release concomitantly with rotational behavior. To test this, rats received electrode and cannulae implants along the medial forebrain bundle, which contains the DAergic nigrostriatal pathway, and a microdialysis probe at the striatum to undergo IVMCD testing. To begin, steady baseline DA levels …
Dopamine Regulation Of Disengagement In The Basal Ganglia Circuitry, Mabel N. Terminel
Dopamine Regulation Of Disengagement In The Basal Ganglia Circuitry, Mabel N. Terminel
Open Access Theses & Dissertations
Evidence suggests that dopamine (DA) is crucial for initiation and termination as well as sustained execution of movement. For the present study, it was hypothesized that DA plays a more important role in initiation and termination of movement than in its sustained production. To test these hypotheses, rats were trained to walk on a treadmill in a continuous and discontinuous (walk 30 secs/stop 15 seconds) fashion for one hour while striatal DA samples were collected using In Vivo Microdialysis (IVMCD). We predicted larger increases during discontinuous compared to continuous walking. It was found that brain dialysate levels of DA consistently …