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Age Impacts Perineuronal Net Density In The Somatosensory Genital Cortex Independently Of Gonadal Steroid Hormones, Ian D. Warren
Age Impacts Perineuronal Net Density In The Somatosensory Genital Cortex Independently Of Gonadal Steroid Hormones, Ian D. Warren
Masters Theses
A hallmark of pubertal development is the rise in gonadal hormone secretions and the subsequent onset of sexual behavior. The size of the somatosensory genital cortex increases in response to both this rise in gonadal steroid hormones and sexual experience. However, whether specific markers of brain plasticity are similarly impacted by gonadal hormones during puberty is not known. Perineuronal nets (PNNs) are specialized extracellular matrix structures that unsheathe neurons as they mature, and their maturation coincides with the closure of sensitive periods across several sensory systems. PNNs in somatosensory cortex, as an example, respond to experience-dependent plasticity. Although experience-depended changes …
Activation Of Nrf2 At Critical Windows Of Development Alters Protein S-Glutathionylation In The Zebrafish Embryo (Danio Rerio), Emily G. Severance
Activation Of Nrf2 At Critical Windows Of Development Alters Protein S-Glutathionylation In The Zebrafish Embryo (Danio Rerio), Emily G. Severance
Masters Theses
Perturbation of cellular redox homeostasis to a more oxidized state has been linked to adverse human health effects such as diabetes and cancer. However, the impact of altering the regulation of redox homeostasis during development is not fully understood. Specifically, this project investigates the role of the Nrf2 antioxidant response pathway and its effect on glutathione (GSH; cellular redox buffer) at critical windows of development. To explore this, we used zebrafish embryos (Danio rerio) as a model due to the function of GSH and the Nrf2 being conserved among vertebrates. We exposed zebrafish embryos to three Nrf2 activators: two antioxidant …
Effects Of Berberine On Development In Caenorhabditis Elegans, Zhuojia Qian
Effects Of Berberine On Development In Caenorhabditis Elegans, Zhuojia Qian
Masters Theses
Berberine is an isoquinoline alkaloid found in some plants and has many bioactivities including anti-microbial, lipid- and glucose-lowering, anti-cancer, anti-inflammatory, etc. However, there is limited knowledge about berberine’s effects on development and locomotive activity. Herein, in vivo studies were conducted to determine these effects of berberine using Caenorhabditis elegans as an in vivo model. Treatment of berberine at 50 μM starting at L1 stage significantly retarded the growth rate of nematodes, and reduced the length, width and moving speed of worms by 19%, 12% and 29%, respectively, compared to the control. In addition, triglycerides (TG) and protein content in worms …
Agritourism Development In Southwest Michigan: Motivations Of Agritourists And Operators, Esther Akoto Amoako
Agritourism Development In Southwest Michigan: Motivations Of Agritourists And Operators, Esther Akoto Amoako
Masters Theses
National agricultural statistics show that the number of agritourism farms and the proportion of agritourism related revenues in the United States has steadily increased during the last ten years, especially among small family farms. The recent growth in agritourism is both demand - and supply-driven. However, there are limited studies that explore agritourism motivations from both the visitors' and operators’ perspectives. This study examines what the agritourists' and operators’ motivations are and the challenges facing the industry to provide information for those currently involved and those wanting to include agritourism in their operations. Online and in-person surveys and unstructured interviews …
Patterns Of Morphological Plasticity In Metriaclima Zebra And Danio Rerio Suggest Differently Canalized Phenotypes Due To Form-Function Relationships, Dylan Jockel
Masters Theses
In order to ascertain the degree of compatibility in developmental restructuring and behavioral plasticity between two fish species frequently made subject of laboratory research (Metriaclima zebra & Danio rerio), alternative trophic niche exposure experiments utilizing novel three-prong feeding treatments were conducted to obtain morphometric data, which demonstrated both species do bear some degree of plasticity. The results are somewhat complicated by differences in locality of detectable restructuring, which may be due to disparity in the form-function relationship for each species’ lineage. Each is notable in the manner of respective species’ jaw protrusion, as it is driven by anterior …
Methylglyoxal Influences Development Of Caenorhabditis Elegans Via Heterochronic Pathway, Jiaying Wang
Methylglyoxal Influences Development Of Caenorhabditis Elegans Via Heterochronic Pathway, Jiaying Wang
Masters Theses
Methylglyoxal is a highly reactive dicarbonyl compound, which is widely distributed in food products and beverages, and is particularly high in Manuka honey. In addition to its antibacterial effects, methylglyoxal is also known as a major precursor of advanced glycation end products (AGEs), that produces altered macromolecules (such as proteins and DNA), leading to abnormal physiological changes. However, the effects of methylglyoxal on development is unclear. Thus, this study aimed to determine the role of methylglyoxal in this aspect using Caenorhabditis elegans (C. elegans). Treatment of methylglyoxal at 0.1 mM and 1 mM for 48 h significantly inhibited …