Digital Commons Network^™

Influence Of A Short-Term, Multicomponent Intervention On Balance And Strength Among The Elderly, Pamela C. Webert

Master's Theses and Doctoral Dissertations

Background: Few studies have combined strength and balance training to assess improvement of activities of daily living among subjects over the age of 65. The purpose of this study was to demonstrate how an eight-week balance and strength training program can lead to improvements in activities of daily living among elderly individuals.

Methods: The subjects consisted of 14 elderly women and 3 elderly men who were all residents of an independent living community. There were 10 subjects in the intervention group and 7 subjects in the control group. The intervention group participated in a supervised balance and strength …

The Molecular And Behavioral Characterization Of Cav1.3 Over-Expressing Mice, Jamie Nicole Slater

Master's Theses and Doctoral Dissertations

Age-related cognitive decline refers to the memory impairment and difficulty learning new tasks that occurs during the normal process of aging. There are many possible changes that occur at the neuronal level that could account for age-related cognitive decline. One hypothesis suggests that a dysregulation of neuronal intracellular calcium concentration contributes to age-related cognitive deficits. Previous research suggests that an increase in neuronal L-type voltage-gated calcium channels (LVGCCs) occurs in the brain during aging. This increase could account for altered intracellular calcium concentration and lead to agerelated cognitive decline. A line of transgenic mice that over-express the LVGCC Ca_{V …}