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The Effect Of Anti-Aging Treatment On Expression Of Aging Markers In A Mouse Model Of Huntington Disease, Mary Isabelle E. Guerra
The Effect Of Anti-Aging Treatment On Expression Of Aging Markers In A Mouse Model Of Huntington Disease, Mary Isabelle E. Guerra
Honors Undergraduate Theses
Huntington disease (HD) is a fatal neurodegenerative disease caused by CAG tract expansion in the huntingtin (HTT) gene, which results in production of mutant huntingtin (mtHTT) protein. Although mtHTT is expressed throughout life, onset of HD symptoms typically begins in mid-life, around 35 to 50 years of age. Characteristic HD symptoms include motor, cognitive, and psychiatric abnormalities. The emergence of symptoms in adulthood suggests that aging may play a role in HD pathogenesis. Furthermore, markers of accelerated aging can be observed in HD patients, including telomere attrition, epigenetic alterations, and mitochondrial dysfunction. Our lab has previously observed that …