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Lipid Raft Disruption Alters Human Follicle Stimulating Hormone Receptor Signaling, Rachel Judith Godek
Lipid Raft Disruption Alters Human Follicle Stimulating Hormone Receptor Signaling, Rachel Judith Godek
Honors Theses
Over 6.7 million people struggle with infertility each year. Studying signaling by reproductive hormones in fertility can allow us to gain a better understanding of the signaling pathways that must function correctly for proper fertility. Some infertility is due to incorrect human follicle stimulating hormone receptor (hFSHR) function. When follicle stimulating hormone (FSH) binds to hFSHR this begins a signaling cascade where the end product is the maturation of sperm by Sertoli cells in men, and egg development and production of estrogen through stimulation of granulosa cells in women. It has been determined that hFSHR is localized to microdomains of …
Mutations In Caveolin Binding Motif Alter Human Follicle Stimulating Hormone Receptor Signaling, Katarina Zahedi
Mutations In Caveolin Binding Motif Alter Human Follicle Stimulating Hormone Receptor Signaling, Katarina Zahedi
Honors Theses
Globally, there are about 48 million couples and 186 million individuals of reproductive age that are affected by infertility. Some cases of infertility in both men and women have been attributed to impaired follicle stimulating hormone (FSH) signaling. The lack of proper function of the cognate receptor for FSH (FSHR) could contribute to infertility since the biochemical signal generated by FSH binding to FSHR stimulates the production of a sperm-stabilizing protein in males and follicle maturation in females. It has been demonstrated that human FSHR (hFSHR) localizes to lipid rafts, which are rigid and detergent-resistant microdomains in the cell membrane. …