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Telomere Length Variation In Preschool Children: Associations With Chronic Family Stress, Maternal Depression, And Cortisol Reactivity, Aditi Thakur
Electronic Thesis and Dissertation Repository
Telomeres are repetitive nucleotide repeats of TTAGGG sequences located at the two ends of each chromosome. Telomeres protect DNA from degradation and maintain genomic stability. Shorter telomeres are implicated in different diseases and disorders including psychiatric disorders. I measured buccal cell telomere length (TL) in 384 pre-school children (3-4 years), from Southwestern Ontario using monochrome multiplex qPCR method. I assessed the associations between TL and family, child-specific variables. I did not find a significant correlation between TL and maternal depression, chronic family stress, or age and sex of the children. However, I found a significant positive correlation between TL and …
Exposure To Environmental Contaminants And Stress As Determinants Of Health In Three Communities: Walpole Island And Attawapiskat First Nations And Naivasha, Kenya, Deirdre Phaedra Henley
Exposure To Environmental Contaminants And Stress As Determinants Of Health In Three Communities: Walpole Island And Attawapiskat First Nations And Naivasha, Kenya, Deirdre Phaedra Henley
Electronic Thesis and Dissertation Repository
This project is an interdisciplinary, community-based, participatory Ecosystem Health investigation with two First Nations in Canada, one located in the far south (Walpole Island; WIFN) and one in the far north (Attawapiskat; AttFN), and a large Kenyan community surrounding Lake Naivasha. The increased human health risks from exposure to three classes of environmental contaminants, persistent organic pollutants (POPs), pesticides and metals, and fear from such exposures are pressing concerns in each setting. Sensitive analysis of 15 metals in hair, six metals and 91 POPs in whole blood or serum of WIFN and AttFN volunteers has been conducted. Whole blood samples …