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The Characterization Of The Rat Bone Sialoprotein Knockout Phenotype, Benjamin Harvey
The Characterization Of The Rat Bone Sialoprotein Knockout Phenotype, Benjamin Harvey
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Bone sialoprotein (BSP) is an extracellular phosphoprotein that has been associated with mineralizing tissues, such as the periodontium, the fibrocartilaginous enthesis, and long bone formation. In this study, we characterized the phenotype of BSP-deficient rats. Histomorphometric analysis discovered a thinning of the acellular cementum in both 20 and 50 week-old Bsp-/- rats with no related periodontal defects and an organized periodontal ligament. Analysis of the mature quadriceps tendon (QCT) enthesis determined that BSP and osteopontin are present in the calcified fibrocartilage of wild-type rats at 14 weeks. The developing QCT enthesis of Bsp-/- rats appears similar in mineral …